PTPLAD1

HACD3
Identifiers
Aliases	HACD3 , B-IND1, BIND1, HSPC121, PTPLAD1, 3-hydroxyacyl-CoA dehydratase 3
External IDs	OMIM: 615940 MGI: 1889341 HomoloGene: 9494 GeneCards: HACD3
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q22.31 Start 65,530,418 bp [1] End 65,578,349 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 C Start 64,894,265 bp [2] End 64,928,975 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons retinal pigment epithelium renal medulla superior vestibular nucleus ventral tegmental area middle temporal gyrus inferior ganglion of vagus nerve subthalamic nucleus entorhinal cortex external globus pallidus Top expressed in Paneth cell substantia nigra facial motor nucleus pineal gland motor neuron fossa condyle suprachiasmatic nucleus pituitary gland anterior horn of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity protein binding lyase activity enzyme binding 3-hydroxyacyl-CoA dehydratase activity 3-hydroxy-lignoceroyl-CoA dehydratase activity 3-hydroxy-behenoyl-CoA dehydratase activity 3-hydroxy-arachidoyl-CoA dehydratase activity very-long-chain 3-hydroxyacyl-CoA dehydratase activity Cellular component integral component of membrane nuclear membrane endoplasmic reticulum membrane membrane focal adhesion endoplasmic reticulum mitochondrion cytosol integral component of endoplasmic reticulum membrane Biological process positive regulation by virus of viral protein levels in host cell lipid metabolism small GTPase mediated signal transduction fatty acid metabolic process JNK cascade fatty acid biosynthetic process very long-chain fatty acid biosynthetic process Rho protein signal transduction fatty acid elongation positive regulation of viral genome replication Rac protein signal transduction I-kappaB kinase/NF-kappaB signaling positive regulation of GTPase activity sphingolipid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51495 57874 Ensembl ENSG00000074696 ENSMUSG00000033629 UniProt Q9P035 Q8K2C9 RefSeq (mRNA) NM_016395 NM_021345 RefSeq (protein) NP_057479 NP_067320 Location (UCSC) Chr 15: 65.53 – 65.58 Mb Chr 9: 64.89 – 64.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein tyrosine phosphatase-like protein PTPLAD1 is an enzyme that in humans is encoded by the PTPLAD1 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000074696 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033629 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Courilleau D, Chastre E, Sabbah M, Redeuilh G, Atfi A, Mester J (Jul 2000). "B-ind1, a novel mediator of Rac1 signaling cloned from sodium butyrate-treated fibroblasts". J Biol Chem. 275 (23): 17344–8. doi: 10.1074/jbc.M000887200 . PMID   10747961.
6. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
7. "Entrez Gene: PTPLAD1 protein tyrosine phosphatase-like A domain containing 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Sabbah M, Saucier C, Redeuilh G (2006). "Human B-ind1 gene promoter: cloning and regulation by histone deacetylase inhibitors". Gene. 374: 128–33. doi:10.1016/j.gene.2006.01.022. PMID   16516406.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.