PTPMT1

PTPMT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RGO, 3RGQ
Identifiers
Aliases	PTPMT1 , DUSP23, MOSP, PLIP, PNAS-129, protein tyrosine phosphatase, mitochondrial 1, protein tyrosine phosphatase mitochondrial 1
External IDs	OMIM: 609538; MGI: 1913711; HomoloGene: 11973; GeneCards: PTPMT1; OMA:PTPMT1 - orthologs
EC number	3.1.3.48
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p11.2 Start 47,565,430 bp [1] End 47,573,461 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E1 Start 90,739,060 bp [2] End 90,748,389 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis putamen left adrenal cortex substantia nigra hypothalamus right adrenal gland caudate nucleus right adrenal cortex nucleus accumbens Top expressed in left ventricle interventricular septum quadriceps femoris muscle spermatid white adipose tissue testicle peripheral nervous system superior cervical ganglion muscle tissue muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity protein binding phosphatidylglycerophosphatase activity protein tyrosine phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity Cellular component membrane mitochondrion mitochondrial inner membrane nucleus Biological process lipid metabolism protein dephosphorylation phospholipid biosynthetic process cardiolipin biosynthetic process peptidyl-tyrosine dephosphorylation dephosphorylation phosphatidylglycerol biosynthetic process regulation of intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114971 66461 Ensembl ENSG00000110536 ENSG00000285206 ENSMUSG00000063235 UniProt Q8WUK0 Q66GT5 RefSeq (mRNA) NM_175732 NM_001143984 NM_025576 RefSeq (protein) NP_001137456 NP_783859 NP_079852 Location (UCSC) Chr 11: 47.57 – 47.57 Mb Chr 2: 90.74 – 90.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein tyrosine phosphatase, mitochondrial 1 is a protein in humans that is primarily coded by the gene PTPMT1 gene. ^[5]

References

1. ENSG00000285206 GRCh38: Ensembl release 89: ENSG00000110536, ENSG00000285206 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063235 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Protein tyrosine phosphatase, mitochondrial 1" . Retrieved 2017-01-12.

Further reading

• Niemi NM, Lanning NJ, Westrate LM, MacKeigan JP (2013). "Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death". PLOS ONE. 8 (1) e53803. Bibcode:2013PLoSO...853803N. doi: 10.1371/journal.pone.0053803 . PMC   3542197 . PMID   23326511.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1)