PTPRCAP

PTPRCAP
Identifiers
Aliases	PTPRCAP , CD45-AP, LPAP, protein tyrosine phosphatase, receptor type C associated protein, protein tyrosine phosphatase receptor type C associated protein
External IDs	OMIM: 601577; MGI: 97811; HomoloGene: 48358; GeneCards: PTPRCAP; OMA:PTPRCAP - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.2 Start 67,435,510 bp [1] End 67,437,682 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 A|19 3.86 cM Start 4,203,603 bp [2] End 4,206,750 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen blood lymph node appendix mucosa of transverse colon bone marrow cells gonad right uterine tube duodenum Top expressed in thymus spleen bone marrow granulocyte jejunum ileum colon pharynx lung morula More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 5790 19265 Ensembl ENSG00000213402 ENSMUSG00000045826 UniProt Q14761 Q64697 RefSeq (mRNA) NM_005608 NM_016933 RefSeq (protein) NP_005599 NP_058629 Location (UCSC) Chr 11: 67.44 – 67.44 Mb Chr 19: 4.2 – 4.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein tyrosine phosphatase receptor type C-associated protein is an enzyme that in humans is encoded by the PTPRCAP gene. ^[5]

The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000213402 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045826 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein".

Further reading

• Schraven B, Schoenhaut D, Bruyns E, Koretzky G, Eckerskorn C, Wallich R, Kirchgessner H, Sakorafas P, Labkovsky B (1994). "LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes". J. Biol. Chem. 269 (46): 29102–11. doi: 10.1016/S0021-9258(19)62018-1 . PMID   7961877.
• Bruyns E, Hendricks-Taylor LR, Meuer S, Koretzky GA, Schraven B (1996). "Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45". J. Biol. Chem. 270 (52): 31372–6. doi: 10.1074/jbc.270.52.31372 . PMID   8537410.
• Bruyns E, Mincheva A, Bruyns RM, Kirchgessner H, Weitz S, Lichter P, Meuer S, Schraven B (1997). "Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes". Genomics. 38 (1): 79–83. doi:10.1006/geno.1996.0595. PMID   8954783.
• Kung C, Okumura M, Seavitt JR, Noll ME, White LS, Pingel JT, Thomas ML (2000). "CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction". Eur. J. Immunol. 29 (12): 3951–5. doi:10.1002/(SICI)1521-4141(199912)29:12<3951::AID-IMMU3951>3.0.CO;2-9. PMID   10602003. S2CID   4962507.
• Woods ML, Kivens WJ, Adelsman MA, Qiu Y, August A, Shimizu Y (2001). "A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor". EMBO J. 20 (6): 1232–44. doi:10.1093/emboj/20.6.1232. PMC   145515 . PMID   11250890.
• Kirchgessner H, Dietrich J, Scherer J, Isomaki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP (2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC   2193385 . PMID   11390434.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Vogel A, Strassburg CP, Manns MP (2003). "77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link". Genes Immun. 4 (1): 79–81. doi:10.1038/sj.gene.6363918. PMID   12595907. S2CID   19853676.
• Cocco E, Murru MR, Melis C, Schirru L, Solla E, Lai M, Rolesu M, Marrosu M (2004). "PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients". J. Neurol. 251 (9): 1085–8. doi:10.1007/s00415-004-0485-1. PMID   15372250. S2CID   35718298.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.