PUF60

Last updated
PUF60
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PUF60 , FIR, RoBPI, SIAHBP1, VRJS, poly(U) binding splicing factor 60KDa, poly(U) binding splicing factor 60
External IDs OMIM: 604819 MGI: 1915209 HomoloGene: 8614 GeneCards: PUF60
Orthologs
SpeciesHumanMouse
Entrez

22827

67959

Ensembl

ENSG00000179950
ENSG00000274081

ENSMUSG00000002524

UniProt

Q9UHX1

Q3UEB3

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr 8: 143.82 – 143.83 Mb Chr 15: 75.94 – 75.95 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Poly(U)-binding-splicing factor PUF60 is a protein that in humans is encoded by the PUF60 gene. [5] [6] [7] [8]

The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene. [8]

Interactions

PUF60 has been shown to interact with U2AF2. [9] [10]

Related Research Articles

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References

  1. 1 2 3 ENSG00000274081 GRCh38: Ensembl release 89: ENSG00000179950, ENSG00000274081 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002524 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Bouffard P, Barbar E, Brière F, Boire G (January 2000). "Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins". RNA. 6 (1): 66–78. doi:10.1017/S1355838200990277. PMC   1369894 . PMID   10668799.
  6. ↑ Liu J, He L, Collins I, Ge H, Libutti D, Li J, Egly JM, Levens D (February 2000). "The FBP interacting repressor targets TFIIH to inhibit activated transcription". Molecular Cell. 5 (2): 331–41. doi: 10.1016/S1097-2765(00)80428-1 . PMID   10882074.
  7. ↑ Hastings ML, Allemand E, Duelli DM, Myers MP, Krainer AR (June 2007). Valcarcel J (ed.). "Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65)". PLOS ONE. 2 (6): e538. Bibcode:2007PLoSO...2..538H. doi: 10.1371/journal.pone.0000538 . PMC   1888729 . PMID   17579712. Open Access logo PLoS transparent.svg
  8. 1 2 "Entrez Gene: SIAHBP1 fuse-binding protein-interacting repressor".
  9. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
  10. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

Further reading



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