PURG

Last updated
PURG
Identifiers
Aliases PURG , PURG-A, PURG-B, purine-rich element binding protein G, purine rich element binding protein G
External IDs MGI: 1922279 HomoloGene: 22747 GeneCards: PURG
Gene location (Human)
Ideogram human chromosome 8.svg
Chr. Chromosome 8 (human) [1]
Human chromosome 8 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 8p12Start30,995,802 bp [1]
End31,033,715 bp [1]
Orthologs
SpeciesHumanMouse
Entrez

29942

75029

Ensembl

ENSG00000172733

ENSMUSG00000049184

UniProt

Q9UJV8

Q8R4E6

RefSeq (mRNA)

NM_001015508
NM_013357
NM_001323311
NM_001323312

NM_001098233
NM_152821

RefSeq (protein)

NP_001015508
NP_001310240
NP_001310241
NP_037489

NP_001091703
NP_690034

Location (UCSC) Chr 8: 31 – 31.03 Mb Chr 8: 33.39 – 33.42 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Purine-rich element binding protein G is a protein that in humans is encoded by the PURG gene. [5]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

Gene Basic physical and functional unit of heredity

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Function

The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A (PURA). The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. Two transcript variants encoding different isoforms have been found for this gene. [5]

PURA protein-coding gene in the species Homo sapiens

Pur-alpha is a protein that in humans is encoded by the PURA gene located at chromosome 5, band q31.

Werner syndrome Human disease. Common in 1 in 2 children. Death is inevitable.

Werner syndrome (WS), also known as "adult progeria", is a rare, autosomal recessive disorder which is characterized by the appearance of premature aging.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172733 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049184 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: Purine-rich element binding protein G" . Retrieved 2015-12-27.

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