PWP2

PWP2
Identifiers
Aliases	PWP2 , EHOC-17, PWP2H, UTP1, PWP2 periodic tryptophan protein homolog (yeast), small subunit processome component, PWP2 small subunit processome component
External IDs	OMIM: 601475; MGI: 1341200; HomoloGene: 136786; GeneCards: PWP2; OMA:PWP2 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q22.3 Start 44,107,373 bp [1] End 44,131,181 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 C1|10 39.72 cM Start 78,006,743 bp [2] End 78,020,983 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium corpus callosum mucosa of transverse colon gastric mucosa gonad skeletal muscle tissue sural nerve prefrontal cortex right adrenal gland blood Top expressed in primitive streak epiblast primary oocyte otic vesicle secondary oocyte otic placode cumulus cell zygote ventricular zone yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function snoRNA binding RNA binding Cellular component Pwp2p-containing subcomplex of 90S preribosome nucleus nucleolus small-subunit processome nucleoplasm Biological process ribosomal small subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5822 110816 Ensembl ENSG00000241945 ENSMUSG00000032834 UniProt Q15269 Q8BU03 RefSeq (mRNA) NM_005049 NM_029546 RefSeq (protein) NP_005040 NP_083822 Location (UCSC) Chr 21: 44.11 – 44.13 Mb Chr 10: 78.01 – 78.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Periodic tryptophan protein 2 homolog is a protein that in humans is encoded by the PWP2 gene. ^{[5] [6]}

Function

This protein is involved in the assembly of small subunit of ribosome. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000241945 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032834 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yamakawa K, Gao DQ, Korenberg JR (Dec 1996). "A periodic tryptophan protein 2 gene homologue (PWP2H) in the candidate region of progressive myoclonus epilepsy on 21q22.3". Cytogenet Cell Genet. 74 (1–2): 140–5. doi:10.1159/000134402. PMID   8893822.
6. "PWP2 PWP2 small subunit processome component [ Homo sapiens (human) ]".

Further reading

• Lalioti MD, Chen H, Rossier C, et al. (1996). "Cloning the cDNA of human PWP2, which encodes a protein with WD repeats and maps to 21q22.3". Genomics. 35 (2): 321–7. doi:10.1006/geno.1996.0363. PMID   8661145.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Lafrenière RG, Rochefort DL, Chrétien N, et al. (1997). "Isolation and genomic structure of a human homolog of the yeast periodic tryptophan protein 2 (PWP2) gene mapping to 21q22.3". Genome Res. 6 (12): 1216–26. doi: 10.1101/gr.6.12.1216 . PMID   8973917.
• Nagamine K, Kudoh J, Kawasaki K, et al. (1997). "Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3". Biochem. Biophys. Res. Commun. 235 (1): 185–90. Bibcode:1997BBRC..235..185N. doi:10.1006/bbrc.1997.6758. PMID   9196060.
• Nagamine K, Kudoh J, Minoshima S, et al. (1997). "Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21". Genomics. 42 (3): 528–31. doi:10.1006/geno.1997.4761. PMID   9205129.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.