PYGO2

PYGO2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2XB1, 4UP0, 4UP5
Identifiers
Aliases	PYGO2 , 1190004M21Rik, pygopus family PHD finger 2
External IDs	OMIM: 606903; MGI: 1916161; HomoloGene: 44519; GeneCards: PYGO2; OMA:PYGO2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	154,963,853 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,342,435 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; cardiac muscle tissue of right atrium; ; myocardium of left ventricle; ; nasal epithelium; ; cardia; ; right adrenal gland; ; anterior pituitary; ; right adrenal cortex; ; granulocyte; ; oocyte;
	Top expressed in
	papillary dermis; ; yolk sac; ; granulocyte; ; dermal papilla; ; cumulus cell; ; gastrula; ; ventricular zone; ; lens; ; epiblast; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	histone binding ; metal ion binding ; protein binding ; chromatin binding ; histone acetyltransferase regulator activity ;
Cellular component	nucleoplasm ; nucleus ; beta-catenin-TCF complex ;
Biological process	roof of mouth development ; regulation of histone H3-K4 methylation ; in utero embryonic development ; regulation of mammary gland epithelial cell proliferation ; positive regulation of chromatin binding ; mammary gland development ; brain development ; lens development in camera-type eye ; developmental growth ; regulation of histone acetylation ; spermatid development ; canonical Wnt signaling pathway ; beta-catenin-TCF complex assembly ; kidney development ; spermatid nucleus differentiation ; post-embryonic development ; Wnt signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	90780
	68911
	ENSG00000163348
	ENSMUSG00000047824
	Q9BRQ0
	n/a
	NM_138300
	NM_001293763 ; NM_001293766 ; NM_001293767 ; NM_001293768 ; NM_026869
	NP_612157
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 03, 2024

Pygopus homolog 2 is a protein that in humans is encoded by the PYGO2 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163348 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047824 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Thompson B, Townsley F, Rosin-Arbesfeld R, Musisi H, Bienz M (May 2002). "A new nuclear component of the Wnt signalling pathway". Nat Cell Biol. 4 (5): 367–73. doi:10.1038/ncb786. PMID 11988739. S2CID 23942463.
↑ "Entrez Gene: PYGO2 pygopus homolog 2 (Drosophila)".

Kramps T, Peter O, Brunner E, et al. (2002). "Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex" (PDF). Cell. 109 (1): 47–60. doi:10.1016/S0092-8674(02)00679-7. PMID 11955446. S2CID 16720801. Archived from the original (PDF) on 2021-09-26. Retrieved 2021-01-31.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Townsley FM, Thompson B, Bienz M (2004). "Pygopus residues required for its binding to Legless are critical for transcription and development". J. Biol. Chem. 279 (7): 5177–83. doi: 10.1074/jbc.M309722200 . PMID 14612447. S2CID 6880212.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039. S2CID 21903526.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC 524842 . PMID 15498874.
Popadiuk CM, Xiong J, Wells MG, et al. (2006). "Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer". Clin. Cancer Res. 12 (7 Pt 1): 2216–23. doi: 10.1158/1078-0432.CCR-05-2433 . PMID 16609037. S2CID 3260972.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Hoffmans R, Basler K (2007). "BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling". Mech. Dev. 124 (1): 59–67. doi: 10.1016/j.mod.2006.09.006 . PMID 17113272. S2CID 17642255.
Andrews PG, Lake BB, Popadiuk C, Kao KR (2007). "Requirement of Pygopus 2 in breast cancer". Int. J. Oncol. 30 (2): 357–63. doi:10.3892/ijo.30.2.357 (inactive 1 November 2024). PMID 17203217.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163348 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047824 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11988739-5] Thompson B, Townsley F, Rosin-Arbesfeld R, Musisi H, Bienz M (May 2002). "A new nuclear component of the Wnt signalling pathway". Nat Cell Biol. 4 (5): 367–73. doi:10.1038/ncb786. PMID 11988739. S2CID 23942463.

[entrez-6] "Entrez Gene: PYGO2 pygopus homolog 2 (Drosophila)".

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PYGO2

Related Research Articles

References

Further reading