Paglicci 23 is the name for human remains found in Paglicci Cave in Apulia, Italy that have been dated to 28,000 years Before Present.
In 2008 a scientific team led by David Caramelli tested Paglicci 23 and found that mtDNA sequences corresponding to positions 16024-16383 were identical to the Cambridge Reference Sequence. The result was exhaustively tested for possible contamination and replicated in a separate test. [1] The paper does not assign any mtDNA haplogroup to the results as the mtDNA segment is too small to draw any conclusions in this regard. Many haplogroups, however, are defined by mutations in this segment as indicated in the table below.
Haplogroup | Position of defining mutation |
---|---|
JT | 16126 |
U1 | 16249 |
U2 | 16051, 16129C |
U3 | 16343 |
U4 | 16356 |
U5 | 16270 |
U6 | 16172, 16219 |
U7 | 16318,T |
K | 16224, 16311 |
B | 16189, 16217 |
F | 16304 |
As a result, the sample can confirm that the mtDNA does not correspond to any of the above modern extant haplogroups. The sample is however confirmed to belong to haplogroup R: 16263 is a critical marker for haplogroup R. The sample does not rule out nor confirm that the sample may belong to haplogroup H as this group is distinguished from haplogroup R by mutations at position 73 which has not been replicated in this study. The haplogroup R node and the CRS sequence are distinguished by various mutations outside the sequenced region.
In human genetics, the Y-chromosomal most recent common ancestor is the patrilineal most recent common ancestor (MRCA) from whom all currently living humans are descended. He is the most recent male from whom all living humans are descended through an unbroken line of their male ancestors. The term Y-MRCA reflects the fact that the Y chromosomes of all currently living human males are directly derived from the Y chromosome of this remote ancestor. The analogous concept of the matrilineal most recent common ancestor is known as "Mitochondrial Eve", the most recent woman from whom all living humans are descended matrilineally. As with "Mitochondrial Eve", the title of "Y-chromosomal Adam" is not permanently fixed to a single individual, but can advance over the course of human history as paternal lineages become extinct.
A haplotype is a group of alleles in an organism that are inherited together from a single parent.
A genealogical DNA test is a DNA-based genetic test used in genetic genealogy that looks at specific locations of a person's genome in order to find or verify ancestral genealogical relationships, or to estimate the ethnic mixture of an individual. Since different testing companies use different ethnic reference groups and different matching algorithms, ethnicity estimates for an individual vary between tests, sometimes dramatically.
A haplotype is a group of alleles in an organism that are inherited together from a single parent, and a haplogroup is a group of similar haplotypes that share a common ancestor with a single-nucleotide polymorphism mutation. More specifically, a haplotype is a combination of alleles at different chromosomal regions that are closely linked and that tend to be inherited together. As a haplogroup consists of similar haplotypes, it is usually possible to predict a haplogroup from haplotypes. Haplogroups pertain to a single line of descent. As such, membership of a haplogroup, by any individual, relies on a relatively small proportion of the genetic material possessed by that individual.
Haplogroup G (M201) is a human Y-chromosome haplogroup. It is one of two branches of the parent haplogroup GHIJK, the other being HIJK.
Haplogroup K, formerly Haplogroup UK, is a human mitochondrial DNA (mtDNA) haplogroup. It is defined by the HVR1 mutations 16224C and 16311C. It is now known that K is a subclade of U8.
Haplogroup J is a human mitochondrial DNA (mtDNA) haplogroup. The clade derives from the haplogroup JT, which also gave rise to haplogroup T. Within the field of medical genetics, certain polymorphisms specific to haplogroup J have been associated with Leber's hereditary optic neuropathy.
Haplogroup HV is a human mitochondrial DNA (mtDNA) haplogroup.
Haplogroup A is a human Y-chromosome DNA haplogroup, which includes all living human Y chromosomes. Bearers of extant sub-clades of haplogroup A are almost exclusively found in Africa, in contrast with haplogroup BT, bearers of which participated in the Out of Africa migration of anatomically modern humans. The known branches of haplogroup A are A00, A0, A1a, and A1b1; these branches are only very distantly related, and are not more closely related to each other than they are to haplogroup BT.
Haplogroup I-M253, also known as I1, is a Y chromosome haplogroup. The genetic markers confirmed as identifying I-M253 are the SNPs M253,M307.2/P203.2, M450/S109, P30, P40, L64, L75, L80, L81, L118, L121/S62, L123, L124/S64, L125/S65, L157.1, L186, and L187. It is a primary branch of Haplogroup I-M170 (I*).
Paglicci Cave is an archaeological site situated in Paglicci, near Rignano Garganico, Apulia, southern Italy. The cave, discovered in the 1950s, is the most important cave of Gargano. The cave is an attraction of the Gargano National Park.
The genetic history of the Middle East is the subject of research within the fields of human population genomics, archaeogenetics and Middle Eastern studies. Researchers use Y-DNA, mtDNA, and other autosomal DNAs to identify the genetic history of ancient and modern populations of Egypt, Persia, Mesopotamia, Anatolia, Arabia, the Levant, and other areas.
Haplogroup H is a human mitochondrial DNA (mtDNA) haplogroup. The clade is believed to have originated in Southwest Asia, near present day Syria, around 20,000 to 25,000 years ago. Mitochondrial haplogroup H is today predominantly found in Europe, and is believed to have evolved before the Last Glacial Maximum (LGM). It first expanded in the northern Near East and Southern Caucasus soon, and later migrations from Iberia suggest that the clade reached Europe before the Last Glacial Maximum. The haplogroup has also spread to parts of Africa, Siberia and inner Asia. Today, around 40% of all maternal lineages in Europe belong to haplogroup H.
In human mitochondrial genetics, Haplogroup M30 is a human mitochondrial DNA (mtDNA) haplogroup.
In human genetics, Haplogroup G-M285, also known as Haplogroup G1, is a Y-chromosome haplogroup. Haplogroup G1 is a primary subclade of haplogroup G.
In human genetics, Haplogroup G-P303 is a Y-chromosome haplogroup. It is a branch of haplogroup G (Y-DNA) (M201). In descending order, G-P303 is additionally a branch of G2 (P287), G2a (P15), G2a2, G2a2b, G2a2b2, and finally G2a2b2a. This haplogroup represents the majority of haplogroup G men in most areas of Europe west of Russia and the Black Sea. To the east, G-P303 is found among G persons across the Middle East, Iran, the southern Caucasus area, China, and India. G-P303 exhibits its highest diversity in the Levant.
The genetic history of the Indigenous peoples of the Americas is divided into two distinct periods: the initial peopling of the Americas during about 20,000 to 14,000 years ago, and European contact, after about 500 years ago. The first period of Indigenous American genetic history is the determinant factor for the number of genetic lineages, zygosity mutations and founding haplotypes present in today's Indigenous American populations.
The genetic history of Egypt reflects its geographical location at the crossroads of several major biocultural areas: North Africa, the Sahara, the Middle East, the Mediterranean and sub-Saharan Africa.