Lassa fever, also known as Lassa hemorrhagic fever (LHF), is a type of viral hemorrhagic fever caused by the Lassa virus. Many of those infected by the virus do not develop symptoms. When symptoms occur they typically include fever, weakness, headaches, vomiting, and muscle pains. Less commonly there may be bleeding from the mouth or gastrointestinal tract. The risk of death once infected is about one percent and frequently occurs within two weeks of the onset of symptoms. Of those who survive, about a quarter have hearing loss, which improves within three months in about half of these cases.
The demographics of Sierra Leone are made up of an indigenous population from 18 ethnic groups. The Temne in the north and the Mende in the south are the largest. About 60,000 are Krio, the descendants of freed slaves who returned to Sierra Leone from Great Britain, North America and slave ships captured on the high seas. In addition, about 5,000 Lebanese, 1,000 Indians, and 5,000 Europeans reside in the country.
Blackwater fever is a complication of malaria infection in which red blood cells burst in the bloodstream (hemolysis), releasing hemoglobin directly into the blood vessels and into the urine, frequently leading to kidney failure. The disease was first linked to malaria by the Sierra Leone Creole physician John Farrell Easmon in his 1884 pamphlet entitled The Nature and Treatment of Blackwater Fever. Easmon coined the name "blackwater fever" and was the first to successfully treat such cases following the publication of his pamphlet.
Lassa mammarenavirus (LASV) is an arenavirus that causes Lassa hemorrhagic fever, a type of viral hemorrhagic fever (VHF), in humans and other primates. Lassa mammarenavirus is an emerging virus and a select agent, requiring Biosafety Level 4-equivalent containment. It is endemic in West African countries, especially Sierra Leone, the Republic of Guinea, Nigeria, and Liberia, where the annual incidence of infection is between 300,000 and 500,000 cases, resulting in 5,000 deaths per year.
Kenema is the third largest city in Sierra Leone, and the largest city in the country's Eastern Province. It is the capital of Kenema District and a major economic center of the Eastern Province. At the 2015 national census, Kenema had a population of 200,354. Kenema is located approximately 200 miles from Freetown, and 60 kilometres (40 mi) south of Bo.
Makeni is the largest city in the Northern Province of Sierra Leone. The city is the capital of Bombali District, and is the economic center of the Northern Province. Makeni is the fifth largest city in Sierra Leone by population. The city of Makeni had a population of 80,840 in the 2004 census and a 2013 estimate of 112,428. Makeni lies approximately 110 miles east of Freetown. Makeni is home to the University of Makeni, the largest private university in Sierra Leone. As with most parts of Sierra Leone, the Krio language of the Sierra Leone Creole people is the most widely spoken language in Makeni.
Kailahun is the capital of Kailahun District in the Eastern Province of Sierra Leone. Kailahun is a major business and commercial center of Kailahun District. The population was 13,108 in the 2004 census, a 2006 estimate of 18,411 and a current estimate of about 30,411. Kailahun lies in the far east of Sierra Leone, approximately 200 miles east of Freetown, about 51 miles north east of Kenema, and near the border of Liberia.
Journey Without Maps (1936) is a travel account by Graham Greene, about a 350-mile, 4-week walk through the interior of Liberia in 1935. It was Greene's first trip outside of Europe. He hoped to leave civilization and find the "heart of darkness" in Africa. The interior of Liberia was at the time poorly mapped, and so he relied on local guides and porters.
In terms of available healthcare and health status Sierra Leone is rated very poorly. Globally, infant and maternal mortality rates remain among the highest. The major causes of illness within the country are preventable with modern technology and medical advances. Most deaths within the country are attributed to nutritional deficiencies, lack of access to clean water, pneumonia, diarrheal diseases, anemia, malaria, tuberculosis and HIV/AIDS.
John Farrell Easmon, MRCS, LM, LKQCP, MD, CMO, was a prominent Sierra Leonean Creole doctor in the British Gold Coast who served as Chief Medical Officer during the 1890s. Easmon was the only West African to be promoted to Chief Medical Officer and he served in this role with distinction during the last decade of the 19th century. Easmon was a botanist and a noted expert on the study and treatment of tropical diseases. In 1884, he wrote a pamphlet entitled The Nature and Treatment of Blackwater Fever, which noted for the first time the relationship between Blackwater fever and malaria. Easmon coined the term "Blackwater fever" in his pamphlet on the malarial disease.
Mattru Jong commonly known as Mattru is the capital of Bonthe District in the Southern Province of Sierra Leone. Mattru Jung is located on the mainland of Bonthe District, along the Jong River, 52 miles southwest of Bo. The town is the seat of Mongerewa Jong Chiefdom, and is the home of Mongerewa Jong Paramount Chief Alie Badara Sheriff III. The town's current estimated population is about 20,000 people. In 2010 it was 8,199, and in the 2004 census the town had a population of 7,647.
Lujo is a bisegmented RNA virus—a member of the family Arenaviridae—and a known cause of viral hemorrhagic fever (VHF) in humans. Its name was suggested by the Special Pathogens Unit of the National Institute for Communicable Diseases of the National Health Laboratory Service (NICD-NHLS) by using the first two letters of the names of the cities involved in the 2008 outbreak of the disease, Lusaka (Zambia) and Johannesburg. It is the second pathogenic Arenavirus to be described from the African continent—the first being Lassa virus—and since 2012 has been classed as a "Select Agent" under U.S. law.
Redeemer's University is a private university in Ede, Osun, off Ibadan-Oshogbo Road, Osun State, Nigeria. Established in 2005, the university is owned by the Redeemed Christian Church of God.
Aniru Sahib Sahib Conteh was a Sierra Leonean physician and expert on the clinical treatment of Lassa fever, a viral hemorrhagic fever endemic to West Africa caused by the Lassa virus. Conteh studied medicine at the University of Ibadan in Nigeria and taught at Ibadan Teaching Hospital. He later returned to Sierra Leone where he joined the Centers for Disease Control and Prevention (CDC) Lassa fever program at Nixon Methodist Hospital in Segbwema, first as superintendent and then as clinical director.
Sheik Umar Khan was the chief Sierra Leonean doctor attempting to curb the country's Ebola outbreak in 2014.
An Ebola virus epidemic in Sierra Leone occurred in 2014, along with the neighbouring countries of Guinea and Liberia. On 18 March 2014, Guinean health officials announced the outbreak of a mysterious hemorrhagic fever "which strikes like lightning". It was identified as Ebola virus disease and spread to Sierra Leone by May 2014. The disease was thought to have originated when a child from a bat-hunting family contracted the disease in Guinea in December 2013.
Oyewale Tomori is a Nigerian professor of virology, educational administrator, and former vice chancellor of Redeemer's University.
Jordi Casals i Ariet was a Catalan physician and epidemiologist.
Patricia Ann Webb was a microbiologist known for her work in characterising and classifying severe contagious diseases including Machupo, Lassa and Ebola viruses.
The African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), located at Redeemer’s University, Ede, Nigeria, is a consortium of West African academic and medical institutions with long-standing partnership in research and training.
