Paul E. Turner | |
---|---|
Nationality | American |
Alma mater | University of Rochester (BA) Michigan State University (PhD) |
Scientific career | |
Fields | Evolutionary Biology, Virology |
Institutions | Yale University Yale School of Medicine |
Thesis | Bacteria and conjugative plasmids: model systems for testing evolutionary theory (1995) |
Doctoral advisor | Richard Lenski |
Paul E. Turner is an American evolutionary biologist and virologist, the Rachel Carson Professor of ecology and evolutionary biology at Yale University, and a faculty member in microbiology at the Yale School of Medicine. [1] [2] His research focuses on the evolutionary genetics of viruses, particularly bacteriophages and RNA viruses transmitted by mosquitoes. [2] [3]
Paul Turner was born in Philadelphia, Pennsylvania in 1966 to Eugene Turner, a Presbyterian minister, and Sylvia Turner, a public schoolteacher. [4] Turner grew up outside of Syracuse, New York, where he spent his childhood among forests and lakes, observing animals in their natural habitats. [4]
Although he entered college at the University of Rochester intending to become an engineer, Turner was encouraged by professors like John Jaenike and Andrew Dobson to pursue graduate work in biology. [4] Despite graduating with a B.A. in Biology in 1988, Turner was still unsure about entering graduate school. [4] At the time, no African American had yet earned a PhD in evolutionary biology. [5] [6] He therefore took a four-month internship at a National Audubon Society wildlife sanctuary in Monson, Maine after graduating. [4] During the internship, Turner convinced himself to apply to graduate programs. [4]
Turner began his graduate studies in the program of Ecology and Evolutionary Biology at the University of California, Irvine in 1989, working with Richard E. Lenski as his PhD advisor. [7] When Lenski’s research group transferred to Michigan State University in 1991, Turner moved with the group and completed his PhD in Zoology (with a certificate from the Ecology, Evolution, and Behavior (EEB) Program) there in 1995. [7] In doing so, Turner became only the fifth African American to receive a PhD in evolutionary biology. [6] During his time in Lenski’s group, Turner studied bacterial systems to address fundamental questions at the interface of ecology and evolution, such as the trade-off between horizontal and vertical transmission in parasites. [8] [9]
Following his graduate studies, Turner completed postdoctoral fellowships at the University of Maryland, College Park, the University of Valencia, and the National Institutes of Health. [7] In 2001, he was appointed as an assistant professor in the Department of Ecology and Evolutionary Biology at Yale University. [7] He was promoted to associate professor in 2006 and full professor in 2011. [7] Turner was a Whitman Center scientist at the Marine Biological Laboratory from 2011 to 2015, where he also served on the faculty of the Molecular Evolution workshop and the Microbial Diversity course. [10]
Turner has co-authored over 150 publications that have together been cited over 6,000 times. [11] Although Turner is known for his foundational work in viral evolution, he has recently begun to apply his insights towards advancing the development of phage therapy against antibiotic-resistant bacterial infections. [12] [13]
A bacteriophage, also known informally as a phage, is a virus that infects and replicates within bacteria and archaea. The term was derived from "bacteria" and the Greek φαγεῖν, meaning "to devour". Bacteriophages are composed of proteins that encapsulate a DNA or RNA genome, and may have structures that are either simple or elaborate. Their genomes may encode as few as four genes and as many as hundreds of genes. Phages replicate within the bacterium following the injection of their genome into its cytoplasm.
Salvador Edward Luria was an Italian microbiologist, later a naturalized U.S. citizen. He won the Nobel Prize in Physiology or Medicine in 1969, with Max Delbrück and Alfred Hershey, for their discoveries on the replication mechanism and the genetic structure of viruses. Salvador Luria also showed that bacterial resistance to viruses (phages) is genetically inherited.
Richard E. Lenski is an American evolutionary biologist, the John A. Hannah Distinguished Professor of Microbial Ecology at Michigan State University. He is a member of the National Academy of Sciences and a MacArthur Fellow. Lenski is best known for his still ongoing 36-year-old long-term E. coli evolution experiment, which has been instrumental in understanding the core processes of evolution, including mutation rates, clonal interference, antibiotic resistance, the evolution of novel traits, and speciation. He is also well known for his pioneering work in studying evolution digitally using self-replicating organisms called Avida.
Christoph Carl Herbert "Chris" Adami is a professor of microbiology and molecular genetics, as well as professor of physics and astronomy, at Michigan State University. He is a core faculty member of the Ecology, Evolution, and Behavior (EEB) Program there.
Bacteriophages (phages), potentially the most numerous "organisms" on Earth, are the viruses of bacteria. Phage ecology is the study of the interaction of bacteriophages with their environments.
Gunther S. Stent was a graduate professor of molecular biology at the University of California, Berkeley. An early bacteriophage biologist, he was known also for his studies on the metabolism of bacteria and neurobiology of leeches, and for his writing on the history and philosophy of biology.
Experimental evolution studies are a means of testing evolutionary theory under carefully designed, reproducible experiments. Given enough time, space, and money, any organism could be used for experimental evolution studies. However, those with rapid generation times, high mutation rates, large population sizes, and small sizes increase the feasibility of experimental studies in a laboratory context. For these reasons, bacteriophages are especially favored by experimental evolutionary biologists. Bacteriophages, and microbial organisms, can be frozen in stasis, facilitating comparison of evolved strains to ancestors. Additionally, microbes are especially labile from a molecular biologic perspective. Many molecular tools have been developed to manipulate the genetic material of microbial organisms, and because of their small genome sizes, sequencing the full genomes of evolved strains is trivial. Therefore, comparisons can be made for the exact molecular changes in evolved strains during adaptation to novel conditions.
Günter P. Wagner is an Austrian-born evolutionary biologist who is Professor of Ecology and Evolutionary biology at Yale University, and head of the Wagner Lab.
Nancy A. Moran is an American evolutionary biologist and entomologist, University of Texas Leslie Surginer Endowed Professor, and co-founder of the Yale Microbial Diversity Institute. Since 2005, she has been a member of the United States National Academy of Sciences. Her seminal research has focused on the pea aphid, Acyrthosiphon pisum and its bacterial symbionts including Buchnera (bacterium). In 2013, she returned to the University of Texas at Austin, where she continues to conduct research on bacterial symbionts in aphids, bees, and other insect species. She has also expanded the scale of her research to bacterial evolution as a whole. She believes that a good understanding of genetic drift and random chance could prevent misunderstandings surrounding evolution. Her current research goal focuses on complexity in life-histories and symbiosis between hosts and microbes, including the microbiota of insects.
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Zachary D. Blount is an American evolutionary biologist best known for his work on the evolution of a key innovation, aerobic growth on citrate, in one of the twelve populations of the E. coli long-term evolution experiment. Blount is a research assistant professor working with Richard Lenski at Michigan State University. He was previously a postdoctoral research assistant for Lenski, and was a visiting assistant professor of biology at Kenyon College from 2018 to 2019.
Anna Marie (Ann) Skalka is an American virologist, molecular biologist and geneticist who is professor emeritus and senior advisor to the president at the Fox Chase Cancer Center. She is a co-author of a textbook on virology, Principles of Virology.
Benjamin K. Chan is a research scientist at Yale University in the department of Ecology and Evolutionary Biology. He was born in 1980 to a U.S. Asian father, an engineer, and an American mother. He is known for his work in phage therapy exploiting genetic trade-offs to treat antibiotic resistant bacterial infections. He currently lives in Guilford, Connecticut.
Martha Rebecca Jane Clokie is a Professor of Microbiology at the University of Leicester. Her research investigates the identification and development of bacteriophages that kill pathogens in an effort to develop new antimicrobials.
Heather Hendrickson is a microbiologist and an Associate Professor in the School of Biological Sciences at the University of Canterbury in Christchurch, New Zealand. She previously worked at Massey University, Auckland, New Zealand. Her research is focussed on the evolution of bacterial cell shape, and the discovery of bacteriophages that can attack antibiotic-resistant bacteria and the bee disease American foulbrood.
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Vincent A. Fischetti is an American microbiologist and immunologist, and Head of the Laboratory of Bacterial Pathogenesis and Immunology at Rockefeller University in New York City.
C. Brandon Ogbunu(gafor) is an American computational biologist who is an Assistant Professor of Ecology and Evolutionary Biology at Yale University, and an External Professor at the Santa Fe Institute. He uses experimental and computational tools to understand the causes of disease, ranging from molecular underpinnings to the social determinants of public health. In addition, he runs a parallel research program at the intersection between science and culture, where he explores the social forces that craft science, and how sciences influences society.
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