Paul J. Hergenrother

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Paul J. Hergenrother is an American chemist and the Kenneth L. Rinehart Jr. Endowed Chair in Natural Products chemistry at the University of Illinois Urbana-Champaign. [1] His research focuses on the development of organic small molecules with novel biological properties such as enzyme inhibitors and activators, chemotherapeutics, and antibacterial agents. In 2008 Hergenrother was awarded the Eli Lilly Award in Biological Chemistry.

Contents

Education

Hergenrother attended college at University of Notre Dame. In 1999, Hergenrother earned his PhD in chemistry from the University of Texas, where he worked in the lab of Professor Stephen F. Martin.

Career and research

From 1999 to 2001, Hergenrother completed an American Cancer Society postdoctoral fellowship at Harvard University in the lab of Professor Stuart Schreiber. [2] In 2001, Hergenrother became a faculty member in the department of chemistry at the University of Illinois Urbana-Champaign. In the spring of 2020, he led the team at the University of Illinois that developed a saliva test for SARS-CoV-2, [3] a test that was widely used throughout the covid-19 pandemic. [4] Several notable biologically active compounds have been discovered in his laboratory, including the anticancer drug PAC-1, [5] the novel antibiotics lolamicin and fabimycin, [6] and raptinal, [7] a widely used tool in apoptotic research. [8]


Notable papers

Web of Science lists 215 publications authored by Hergenrother in peer-reviewed scientific journals that have been cited over 8000 times. [9] His three most cited research articles have been cited >200 times each. [10] [11]

Awards and honors

Source: [1]

References

  1. 1 2 "Paul J. Hergenrother | Chemistry at Illinois". chemistry.illinois.edu. Retrieved 2023-01-07.
  2. ↑ Kuruvilla, Finny G.; Shamji, Alykhan F.; Sternson, Scott M.; Hergenrother, Paul J.; Schreiber, Stuart L. (2002). "Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays" . Nature. 416 (6881): 653–657. Bibcode:2002Natur.416..653K. doi:10.1038/416653a. ISSN   1476-4687. PMID   11948353. S2CID   4424969.
  3. ↑ Peplow, Mark; C, special to; EN (2025-01-21). "How one university built a COVID-19 screening system". Chemical & Engineering News. Retrieved 2025-12-15.
  4. ↑ Cotti, Sol. "How U. of I. Turned Its COVID Test Into a Money Maker". Chicago Magazine. Retrieved 2025-12-15.
  5. ↑ Boudreau, Matthew W.; Peh, Jessie; Hergenrother, Paul J. (2019-11-15). "Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential". ACS Chemical Biology. 14 (11): 2335–2348. doi:10.1021/acschembio.9b00338. ISSN   1554-8937. PMC   6858495 . PMID   31260254.
  6. ↑ Parker, Erica N.; Cain, Brett N.; Hajian, Behnoush; Ulrich, Rebecca J.; Geddes, Emily J.; Barkho, Sulyman; Lee, Hyang Yeon; Williams, John D.; Raynor, Malik; Caridha, Diana; Zaino, Angela; Shekhar, Mrinal; Muñoz, Kristen A.; Rzasa, Kara M.; Temple, Emily R. (2022-08-24). "An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections". ACS Central Science. 8 (8): 1145–1158. doi:10.1021/acscentsci.2c00598. ISSN   2374-7943. PMC   9413440 . PMID   36032774.
  7. ↑ Palchaudhuri, Rahul; Lambrecht, Michael J.; Botham, Rachel C.; Partlow, Kathryn C.; van Ham, Tjakko J.; Putt, Karson S.; Nguyen, Laurie T.; Kim, Seok-Ho; Peterson, Randall T.; Fan, Timothy M.; Hergenrother, Paul J. (2015-12-01). "A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed". Cell Reports. 13 (9): 2027–2036. doi:10.1016/j.celrep.2015.10.042. ISSN   2211-1247. PMC   4683402 . PMID   26655912.
  8. ↑ Smith, Amanda J.; Hergenrother, Paul J. (2024-08-21). "Raptinal: a powerful tool for rapid induction of apoptotic cell death". Cell Death Discovery. 10 (1): 371. doi:10.1038/s41420-024-02120-1. ISSN   2058-7716. PMC   11335860 . PMID   39164225.
  9. ↑ "Web of Science" . Retrieved 7 January 2023.
  10. ↑ Richter, Michelle F.; Drown, Bryon S.; Riley, Andrew P.; Garcia, Alfredo; Shirai, Tomohiro; Svec, Riley L.; Hergenrother, Paul J. (2017-05-18). "Predictive compound accumulation rules yield a broad-spectrum antibiotic". Nature. 545 (7654): 299–304. Bibcode:2017Natur.545..299R. doi:10.1038/nature22308. ISSN   0028-0836. PMC   5737020 . PMID   28489819.
  11. ↑ Huigens III, Robert W.; Morrison, Karen C.; Hicklin, Robert W.; Flood Jr, Timothy A.; Richter, Michelle F.; Hergenrother, Paul J. (2013). "A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products". Nature Chemistry. 5 (3): 195–202. Bibcode:2013NatCh...5..195H. doi:10.1038/nchem.1549. ISSN   1755-4330. PMC   3965367 . PMID   23422561.
  12. ↑ "The David W. Robertson Award". www.acsmedchem.org. Retrieved 2023-01-07.
  13. ↑ "Previous Eli Lilly Award in Biological Chemistry Recipients" (PDF). ACS Division of Biological Chemistry. Archived from the original (PDF) on 21 October 2023. Retrieved 7 January 2023.
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