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Toremifene, sold under the brand name Fareston among others, is a medication which is used in the treatment of advanced breast cancer in postmenopausal women. It is taken by mouth.
Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. It has been researched for the treatment of autoimmune diseases and skin diseases, and to prevent rejection after an organ transplant.
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Lasofoxifene, sold under the brand name Fablyn, is a nonsteroidal selective estrogen receptor modulator (SERM) which is marketed by Pfizer in Lithuania and Portugal for the prevention and treatment of osteoporosis and for the treatment of vaginal atrophy, and the result of an exclusive research collaboration with Ligand Pharmaceuticals (LGND). It also appears to have had a statistically significant effect of reducing breast cancer in women according to a study published in The Journal of the National Cancer Institute.
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Mericitabine (RG-7128) is an antiviral drug, a deoxycytidine analog. It was developed as a treatment for hepatitis C, acting as a NS5B RNA polymerase inhibitor, but while it showed a good safety profile in clinical trials, it was not sufficiently effective to be used as a stand-alone agent. However mericitabine has been shown to boost the efficacy of other antiviral drugs when used alongside them, and as most modern treatment regimens for hepatitis C use a combination therapy of several antiviral drugs, clinical trials have continued to see if it can form a part of a clinically useful drug treatment program.
GS-6620 is an antiviral drug which is a nucleotide analogue. It was developed for the treatment of Hepatitis C but while it showed potent antiviral effects in early testing, it could not be successfully formulated into an oral dosage form due to low and variable absorption in the intestines which made blood levels unpredictable. It has however continued to be researched as a potential treatment for other viral diseases such as Ebola virus disease.
References
- 1 2 Feun L, Savaraj N (July 2006). "Pegylated arginine deiminase: a novel anticancer enzyme agent". Expert Opinion on Investigational Drugs. 15 (7): 815–22. doi:10.1517/13543784.15.7.815. PMC 3086545 . PMID 16787144.
- ↑ Kuo MT, Savaraj N, Feun LG (August 2010). "Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes". Oncotarget. 1 (4): 246–51. doi:10.18632/oncotarget.135. PMC 2998341 . PMID 21152246.
- ↑ Synakiewicz A, Stachowicz-Stencel T, Adamkiewicz-Drozynska E (November 2014). "The role of arginine and the modified arginine deiminase enzyme ADI-PEG 20 in cancer therapy with special emphasis on Phase I/II clinical trials". Expert Opinion on Investigational Drugs. 23 (11): 1517–29. doi:10.1517/13543784.2014.934808. PMID 24965808.
- ↑ Field GC, Pavlyk I, Szlosarek PW (February 2023). "Bench-to-Bedside Studies of Arginine Deprivation in Cancer". Molecules. 28 (5). Basel, Switzerland: 2150. doi: 10.3390/molecules28052150 . PMC 10005060 . PMID 36903394.