Peptidase inhibitor 15

PI15
Identifiers
Aliases	PI15 , CRISP8, P24TI, P25TI, peptidase inhibitor 15
External IDs	OMIM: 607076 MGI: 1934659 HomoloGene: 22935 GeneCards: PI15
Gene location (Human)
Chr.	Chromosome 8 (human)
End	74,855,029 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	17,701,163 bp
RNA expression pattern
	Top expressed in
	lactiferous duct; ; appendix; ; left uterine tube; ; seminal vesicula; ; smooth muscle tissue; ; prostate; ; visceral pleura; ; urethra; ; superficial temporal artery; ; myometrium;
	Top expressed in
	ascending aorta; ; aortic valve; ; glomerulus; ; uterus; ; Bowman's capsule; ; vas deferens; ; esophagus; ; lip; ; belly cord; ; zone of skin;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase inhibitor activity ;
Cellular component	extracellular exosome ; extracellular region ; extracellular space ;
Biological process	negative regulation of peptidase activity ; multicellular organism development ; biological process ;
	Sources:Amigo / QuickGO
Orthologs
	51050
	94227
	ENSG00000137558
	ENSMUSG00000067780
	O43692
	Q8BS03
	NM_015886 ; NM_001324403
	NM_053191
	NP_001311332 ; NP_056970
	NP_444421
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2022

Peptidase inhibitor 15 is a protein that in humans is encoded by the PI15 gene. ^[5]

Function

This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008].

Related Research Articles

Alpha 1-antichymotrypsin is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene.

Matrix metalloproteinase-14 is an enzyme that in humans is encoded by the MMP14 gene.

Membrane-bound transcription factor site-1 protease, or site-1 protease (S1P) for short, also known as subtilisin/kexin-isozyme 1 (SKI-1), is an enzyme that in humans is encoded by the MBTPS1 gene. S1P cleaves the endoplasmic reticulum loop of sterol regulatory element-binding protein (SREBP) transcription factors.

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.

Calpain-9 is a protein that in humans is encoded by the CAPN9 gene.

RAS-like, estrogen-regulated, growth inhibitor is a protein in humans that is encoded by the RERG gene.

Calpain-6 is a protein in humans that is encoded by the CAPN6 gene.

Ubiquitin specific peptidase 19 is a protein that in humans is encoded by the USP19 gene.

Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene.

Interleukin 17 receptor D is a protein that in humans is encoded by the IL17RD gene.

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. Fasudil is an inhibitor of ROCK protein.

Ubiquitin specific peptidase 38 is a protein that in humans is encoded by the USP38 gene.

Peptidase inhibitor 16 is a protein that in humans is encoded by the PI16 gene.

Ubiquitin specific peptidase 54 is a protein that in humans is encoded by the USP54 gene.

Lon peptidase 2, peroxisomal is a protein that in humans is encoded by the LONP2 gene.

Forkhead box S1 is a protein that in humans is encoded by the FOXS1 gene.

Zinc finger containing ubiquitin peptidase 1 is a protein that in humans is encoded by the ZUP1 gene.

Serine protease 57 is a protein that in humans is encoded by the PRSS57 gene.

UFM1 specific peptidase 1 (inactive) is a protein that in humans is encoded by the UFSP1 gene.

UFM1 specific peptidase 2 is a protein that in humans is encoded by the UFSP2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000137558 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067780 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Peptidase inhibitor 15" . Retrieved 2018-08-01.

Peptidase inhibitor 15

Contents

Function

Related Research Articles

References

Further reading