Philippe Lehert

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Philippe Lehert
Philippe Lehert.jpg
Born (1949-08-01) August 1, 1949 (age 75)
Belgium
CitizenshipBelgium
Alma mater University of Louvain
Scientific career
Fields Mathematical statistics, Biostatistics

Philippe Lehert (born August 1, 1949) is a Belgian scientist specializing in mathematical statistics and biostatistics.

Contents

Early life and education

Lehert earned a Master of Science in Applied Mathematics and Engineering from the Faculty of Applied Mathematics in Mons, Belgium, in 1974. He later completed his PhD at the Department of Mathematics of Mons University, focusing on computational complexity in cluster analysis within Euclidean spaces. [1]

Achievements

Lehert is an Honorary Professor at the School of Management, Louvain University, Belgium, and the Faculty of Medicine at the University of Melbourne, Australia. He has also served as a statistical adviser for the United Nations and a member of the Belgian Board of Statistics.[ citation needed ]

His research includes the development of statistical techniques for evaluating the long-term effects of anti-diabetic drugs [2] and methods for randomized trials in addiction, psychiatric disorders, and cardiovascular diseases. [3] [4] [5] [6] [7] He contributed to new developments of Structural Equation Modeling to assess the impact of lifestyle on aging, and menopausal effects on mood and bone loss. [8]

, [9] Lehert developed predictive models In Vitro Fertilization probability of pregnancy, [10] [11] [12] [13] and survival of extremely preterm infants. [14]

In the field of pattern recognition and artificial intelligence, he provided the first demonstration of the linear expected time O(n) complexity of clustering by connected components for any Minkowsky distances, based on cubic tessellations structures in hyperspaces. [15] [16]

References

  1. ↑ "Philippe Lehert". scholar.google.com. Retrieved 2025-01-24.
  2. ↑ de Jager, Jolien; Kooy, Adriaan; Lehert, Philippe; Wulffelé, Michiel G.; van der Kolk, Jan; Bets, Daniël; Verburg, Joop; Donker, Ab J. M.; Stehouwer, Coen D. A. (2010-05-20). "Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial". BMJ (Clinical Research Ed.). 340: c2181. doi:10.1136/bmj.c2181. ISSN   1756-1833. PMC   2874129 . PMID   20488910.
  3. ↑ Stultiens, Johanna M. G.; Top, Wiebe M. C.; Kimenai, Dorien M.; Lehert, Philippe; Bekers, Otto; Stehouwer, Coen D. A.; Kooy, Adriaan; Meex, Steven J. R. (2022-04-04). "Metformin and high-sensitivity cardiac troponin I and T trajectories in type 2 diabetes patients: a post-hoc analysis of a randomized controlled trial". Cardiovascular Diabetology. 21 (1): 49. doi: 10.1186/s12933-022-01482-z . ISSN   1475-2840. PMC   8981770 . PMID   35379238.
  4. ↑ Top, Wiebe M. C.; Lehert, Philippe; Schalkwijk, Casper G.; Stehouwer, Coen D. A.; Kooy, Adriaan (2021-04-08). "Metformin and N-terminal pro B-type natriuretic peptide in type 2 diabetes patients, a post-hoc analysis of a randomized controlled trial". PLOS ONE. 16 (4): e0247939. Bibcode:2021PLoSO..1647939T. doi: 10.1371/journal.pone.0247939 . ISSN   1932-6203. PMC   8031400 . PMID   33830998.
  5. ↑ Top, Wiebe M. C.; Lehert, Philippe; Schalkwijk, Casper G.; Stehouwer, Coen D. A.; Kooy, Adriaan (2022). "Effect of metformin on arginine and dimethylarginines in patients with advanced type 2 diabetes: A post hoc analysis of a randomized trial". Diabetes, Obesity and Metabolism. 24 (10): 1983–1988. doi:10.1111/dom.14784. ISSN   1463-1326. PMID   35789192.
  6. ↑ Top, Wiebe M. C.; Lehert, Philippe; Schalkwijk, Casper G.; Stehouwer, Coen D. A.; Kooy, Adriaan (2021). "Metformin and N-terminal pro B-type natriuretic peptide in type 2 diabetes patients, a post-hoc analysis of a randomized controlled trial". PLOS ONE. 16 (4): e0247939. Bibcode:2021PLoSO..1647939T. doi: 10.1371/journal.pone.0247939 . ISSN   1932-6203. PMC   8031400 . PMID   33830998.
  7. ↑ Duvauchelle, Thierry; Robert, Philippe; Donazzolo, Yves; Loyau, Sabrina; Orlandini, Bernard; Lehert, Philippe; Lecomte, Jeanne-Marie; Schwartz, Jean-Charles (2023). "Bioavailability and cardiovascular effects of adrenaline administered by Anapen 500 μg auto-injector in healthy volunteers". British Journal of Clinical Pharmacology. 89 (3): 1012–1019. doi: 10.1111/bcp.15545 . ISSN   1365-2125. PMID   36136762.
  8. ↑ Dennerstein, Lorraine; Lehert, Philippe; Burger, Henry G.; Guthrie, Janet R. (2007). "New findings from non-linear longitudinal modelling of menopausal hormone changes". Human Reproduction Update. 13 (6): 551–557. doi:10.1093/humupd/dmm022. ISSN   1355-4786. PMID   17616552.
  9. ↑ Lehert, Philippe (2015-12-26). "Towards better meta-analyses in assisted reproductive technology: Fixed, random or multivariate models?". World Journal of Meta-Analysis. 3 (6): 225–231. doi: 10.13105/wjma.v3.i6.225 .
  10. ↑ Lehert, P.; Arvis, P.; Avril, C.; Massin, N.; Parinaud, J.; Porcu, G.; Rongières, C.; Sagot, P.; Wainer, R.; D'Hooghe, T. (2021-05-17). "A large observational data study supporting the PROsPeR score classification in poor ovarian responders according to live birth outcome". Human Reproduction (Oxford, England). 36 (6): 1600–1610. doi:10.1093/humrep/deab050. ISSN   1460-2350. PMID   33860313.
  11. ↑ "endometrial biopsy after micronized progesterone". Jan 2009.
  12. ↑ "Search - Inserm - Institut national de la santé et de la recherche médicale". inserm.hal.science. Retrieved 2025-01-24.
  13. ↑ Lehert, Philippe; Chin, Wai; Schertz, Joan; D'Hooghe, Thomas; Alviggi, Carlo; Humaidan, Peter (July 2018). "Predicting live birth for poor ovarian responders: the PROsPeR concept". Reproductive Biomedicine Online. 37 (1): 43–52. doi:10.1016/j.rbmo.2018.03.013. ISSN   1472-6491. PMID   29731240.
  14. ↑ Baud, Olivier; Lehert, Philippe (2024-10-24). "Bronchopulmonary dysplasia to predict neurodevelopmental impairment in infants born extremely preterm". Pediatric Research: 1–7. doi: 10.1038/s41390-024-03601-w . ISSN   1530-0447. PMID   39448816.
  15. ↑ "Classification en composantes connexes, cas particulier de l'ultramétrique inférieure maximale: un algorithme O(n) en temps moyen" (PDF). Numdam. 1992.
  16. ↑ "Critical percolation properties to prove existence of O(n) expected time single linkage clustering algorithm at a predetermined threshold". ResearchGate. January 1995.
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