Phosducin

PDC
Identifiers
Aliases	PDC , MEKA, PHD, PhLOP, PhLP, phosducin
External IDs	OMIM: 171490 MGI: 98090 HomoloGene: 1950 GeneCards: PDC
Gene location (Human)
Chr.	Chromosome 1 (human)
End	186,461,114 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	150,209,657 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; corpus callosum; ; Achilles tendon; ; Brodmann area 9; ; tibial nerve; ; striated muscle tissue; ; skeletal muscle tissue; ; gastrocnemius muscle; ; body of pancreas; ; substantia nigra;
	Top expressed in
	retinal pigment epithelium; ; ciliary body; ; corneal stroma; ; iris; ; pineal gland; ; gallbladder; ; conjunctival fornix; ; internal carotid artery; ; basilar part of occipital bone; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase inhibitor activity ; queuine tRNA-ribosyltransferase activity ;
Cellular component	photoreceptor inner segment ; cytoplasm ; cytosol ; photoreceptor outer segment ; cell projection ; cilium ; nucleus ;
Biological process	queuosine biosynthetic process ; G protein-coupled receptor signaling pathway ; response to stimulus ; visual perception ; phototransduction ; negative regulation of catalytic activity ;
	Sources:Amigo / QuickGO
Orthologs
	5132
	20028
	ENSG00000116703
	ENSMUSG00000006007
	P20941 ; Q52LP8
	Q9QW08
	NM_002597 ; NM_022576 ; NM_022577
	NM_001159730 ; NM_024458
	NP_002588 ; NP_072098 ; NP_002588.3
	NP_001153202 ; NP_077778
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated May 10, 2023

Phosducin, also known as PDC, is a human protein and gene.^[5] It belongs to the phosducin family of proteins.

This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. By associating with these subunits only, the transducin alpha subunit will remain active for longer. This will increase the amount of time of visual excitation.

This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.^[5]

Related Research Articles

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene.

5'-AMP-activated protein kinase subunit gamma-2 is an enzyme that in humans is encoded by the PRKAG2 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 is a protein that in humans is encoded by the GNB2 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene.

Beta-adducin is a protein that in humans is encoded by the ADD2 gene.

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.

Phosducin-like protein is a protein that in humans is encoded by the PDCL gene.

Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene.

Gamma-aminobutyric acid receptor subunit rho-1 is a protein that in humans is encoded by the GABRR1 gene.

Voltage-dependent L-type calcium channel subunit beta-4 is a protein that in humans is encoded by the CACNB4 gene.

Tropomodulin-1 is a protein that in humans is encoded by the TMOD1 gene.

Guanine nucleotide-binding protein G(t) subunit alpha-2 is a protein that in humans is encoded by the GNAT2 gene.

5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene.

Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene.

Guanine nucleotide-binding protein G(T) subunit gamma-T1 is a protein that in humans is encoded by the GNGT1 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene.

Guanine nucleotide-binding protein subunit beta-4 is a protein that in humans is encoded by the GNB4 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 is a protein that in humans is encoded by the GNG11 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 is a protein that in humans is encoded by the GNG5 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 is a protein that in humans is encoded by the GNGT2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116703 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006007 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: PDC phosducin".

Abe T, Nakabayashi H, Tamada H, et al. (1990). "Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland". Gene. 91 (2): 209–15. doi:10.1016/0378-1119(90)90090-E. PMID 2210381.
Watanabe Y, Kawasaki K, Miki N, Kuo CH (1990). "Isolation and analysis of the human MEKA gene encoding a retina-specific protein". Biochem. Biophys. Res. Commun. 170 (2): 951–6. doi:10.1016/0006-291X(90)92183-Z. PMID 2383274.
Lee RH, Brown BM, Lolley RN (1990). "Protein kinase A phosphorylates retinal phosducin on serine 73 in situ". J. Biol. Chem. 265 (26): 15860–6. doi: 10.1016/S0021-9258(18)55478-8 . PMID 2394752.
Hawes BE, Touhara K, Kurose H, et al. (1994). "Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling". J. Biol. Chem. 269 (47): 29825–30. doi: 10.1016/S0021-9258(18)43955-5 . PMID 7961975.
Abe T, Kikuchi T, Shinohara T (1994). "The sequence of the human phosducin gene (PDC) and its 5'-flanking region". Genomics. 19 (2): 369–72. doi:10.1006/geno.1994.1072. PMID 8188267.
Sparkes RS, Lee RH, Shinohara T, et al. (1994). "Assignment of the phosducin (PDC) gene to human chromosome 1q25-1q32.1 by somatic cell hybridization and in situ hybridization". Genomics. 18 (2): 426–8. doi:10.1006/geno.1993.1490. PMID 8288249.
Ding C, Li X, Griffin CA, et al. (1994). "The gene for human phosducin (PDC), a soluble protein that binds G-protein beta gamma dimers, maps to 1q25-q31.1". Genomics. 18 (2): 457–9. doi: 10.1006/geno.1993.1501 . PMID 8288259.
Boekhoff I, Touhara K, Danner S, et al. (1997). "Phosducin, potential role in modulation of olfactory signaling". J. Biol. Chem. 272 (7): 4606–12. doi: 10.1074/jbc.272.7.4606 . PMID 9020189.
Barhite S, Thibault C, Miles MF (1998). "Phosducin-like protein (PhLP), a regulator of G beta gamma function, interacts with the proteasomal protein SUG1". Biochim. Biophys. Acta. 1402 (1): 95–101. doi: 10.1016/S0167-4889(97)00141-9 . PMID 9551090.
Zhu X, Craft CM (1998). "Interaction of phosducin and phosducin isoforms with a 26S proteasomal subunit, SUG1". Mol. Vis. 4: 13. PMID 9701609.
Craft CM, Xu J, Slepak VZ, et al. (1998). "PhLPs and PhLOPs in the phosducin family of G beta gamma binding proteins". Biochemistry. 37 (45): 15758–72. doi:10.1021/bi980921a. PMID 9843381.
Carpten JD, Makalowska I, Robbins CM, et al. (2000). "A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region". Genomics. 64 (1): 1–14. doi:10.1006/geno.1999.6051. PMID 10708513.
Zhu X, Craft CM (2000). "The carboxyl terminal domain of phosducin functions as a transcriptional activator". Biochem. Biophys. Res. Commun. 270 (2): 504–9. doi:10.1006/bbrc.2000.2414. PMID 10753654.
Zhu X, Craft CM (2000). "Modulation of CRX transactivation activity by phosducin isoforms". Mol. Cell. Biol. 20 (14): 5216–26. doi:10.1128/MCB.20.14.5216-5226.2000. PMC 85970 . PMID 10866677.
Ruiz-Gómez A, Humrich J, Murga C, et al. (2000). "Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2". J. Biol. Chem. 275 (38): 29724–30. doi: 10.1074/jbc.M001864200 . PMID 10884381.
Nakano K, Chen J, Tarr GE, et al. (2001). "Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4693–8. Bibcode:2001PNAS...98.4693N. doi: 10.1073/pnas.071067198 . PMC 31896 . PMID 11287646.
Thulin CD, Savage JR, McLaughlin JN, et al. (2001). "Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding". J. Biol. Chem. 276 (26): 23805–15. doi: 10.1074/jbc.M101482200 . PMID 11331285.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Margulis A, Dang L, Pulukuri S, et al. (2002). "Presence of phosducin in the nuclei of bovine retinal cells". Mol. Vis. 8: 477–82. PMID 12500174.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116703 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006007 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: PDC phosducin".

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Phosducin

Contents

See also

Related Research Articles

References

Further reading