Phosphatidic acid phosphatase 2c

PLPP2
Identifiers
Aliases	PLPP2 , LPP2, PAP-2c, PAP2-g, PPAP2C, Phosphatidic acid phosphatase 2c, phospholipid phosphatase 2
External IDs	OMIM: 607126; MGI: 1354945; HomoloGene: 2752; GeneCards: PLPP2; OMA:PLPP2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 281,040 bp [1] End 291,403 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 C1|10 39.72 cM Start 79,362,264 bp [2] End 79,369,630 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa right uterine tube mucosa of transverse colon minor salivary glands C1 segment gallbladder epithelium of bronchus skin of abdomen bronchial epithelial cell skin of leg Top expressed in ileum duodenum crypt of lieberkuhn of small intestine pyloric antrum intestinal villus transitional epithelium of urinary bladder jejunum medullary collecting duct left colon endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity protein binding lipid phosphatase activity hydrolase activity sphingosine-1-phosphate phosphatase activity phosphatidate phosphatase activity phosphatase activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process phospholipid metabolic process sphingolipid biosynthetic process phospholipid dephosphorylation signal transduction protein dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8612 50784 Ensembl ENSG00000141934 ENSMUSG00000052151 UniProt O43688 Q9DAX2 RefSeq (mRNA) NM_003712 NM_177526 NM_177543 NM_015817 NM_001302389 NM_001302390 NM_001302442 RefSeq (protein) NP_003703 NP_803545 NP_808211 NP_001289318 NP_001289319 NP_001289371 NP_056632 Location (UCSC) Chr 19: 0.28 – 0.29 Mb Chr 10: 79.36 – 79.37 Mb PubMed search [3] [4]
Wikidata
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Lipid phosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the PPAP2C gene. ^{[5] [6] [7]}

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000141934 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052151 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Leung DW, Tompkins CK, White T (May 1998). "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells". DNA Cell Biol. 17 (4): 377–85. doi:10.1089/dna.1998.17.377. PMID   9570154.
6. Hooks SB, Ragan SP, Lynch KR (Jun 1998). "Identification of a novel human phosphatidic acid phosphatase type 2 isoform". FEBS Lett. 427 (2): 188–92. doi:10.1016/S0014-5793(98)00421-9. PMID   9607309. S2CID   31610109.
7. "Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C".

Further reading

• Nanjundan M, Possmayer F (2003). "Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L1–23. doi:10.1152/ajplung.00029.2002. PMID   12471011.
• Morris KE, Schang LM, Brindley DN (2006). "Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts". J. Biol. Chem. 281 (14): 9297–306. doi: 10.1074/jbc.M511710200 . PMID   16467304.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang N, Sundberg JP, Gridley T (2000). "Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile". Genesis. 27 (4): 137–40. doi:10.1002/1526-968X(200008)27:4<137::AID-GENE10>3.0.CO;2-4. PMID   10992322. S2CID   24643785.
• Roberts R, Sciorra VA, Morris AJ (1998). "Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform". J. Biol. Chem. 273 (34): 22059–67. doi: 10.1074/jbc.273.34.22059 . PMID   9705349.