Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

LHPP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X4D
Identifiers
Aliases	LHPP , HDHD2B, phospholysine phosphohistidine inorganic pyrophosphate phosphatase
External IDs	OMIM: 617231 MGI: 1923679 HomoloGene: 41469 GeneCards: LHPP
Gene location (Human)
Chr.	Chromosome 10 (human)
End	124,617,888 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	132,308,149 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; tibial nerve; ; inferior olivary nucleus; ; hypothalamus; ; amygdala; ; substantia nigra; ; putamen; ; caudate nucleus; ; nucleus accumbens; ; inferior ganglion of vagus nerve;
	Top expressed in
	lip; ; left lobe of liver; ; crypt of lieberkuhn of small intestine; ; internal carotid artery; ; external carotid artery; ; primitive streak; ; skin of abdomen; ; ileum; ; jejunum; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity ; protein homodimerization activity ; Inorganic pyrophosphatase ; magnesium ion binding ; metal ion binding ; phosphatase activity ; protein histidine phosphatase activity ;
Cellular component	cytosol ; nucleus ; cytoplasm ; nuclear speck ;
Biological process	phosphate-containing compound metabolic process ; purine ribonucleoside monophosphate biosynthetic process ; protein dephosphorylation ; dephosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	64077
	76429
	ENSG00000107902
	ENSMUSG00000030946
	Q9H008
	Q9D7I5
	NM_001167880 ; NM_022126 ; NM_001318331 ; NM_001318332
	NM_029609
	NP_001161352 ; NP_001305260 ; NP_001305261 ; NP_071409
	NP_083885
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase is a protein that in humans is encoded by the LHPP gene. ^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107902 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030946 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Phospholysine phosphohistidine inorganic pyrophosphate phosphatase" . Retrieved 2018-07-14.

Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (January 2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225 . PMID 16385451.
Neff CD, Abkevich V, Packer JC, Chen Y, Potter J, Riley R, Davenport C, DeGrado Warren J, Jammulapati S, Bhathena A, Choi WS, Kroeger PE, Metzger RE, Gutin A, Skolnick MH, Shattuck D, Katz DA (June 2009). "Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression". Mol. Psychiatry. 14 (6): 621–30. doi: 10.1038/mp.2008.8 . PMID 18268499.
Neff CD, Abkevich V, Packer JC, Chen Y, Potter J, Riley R, Davenport C, DeGrado Warren J, Jammulapati S, Bhathena A, Choi WS, Kroeger PE, Metzger RE, Gutin A, Skolnick MH, Shattuck D, Katz DA (June 2009). "Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression". Mol. Psychiatry. 14 (6): 621–30. doi: 10.1038/mp.2008.8 . PMID 18268499.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464 . PMID 20379614.
Polimanti R, Wang Q, Meda SA, Patel KT, Pearlson GD, Zhao H, Farrer LA, Kranzler HR, Gelernter J (February 2017). "The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene". Neuropsychopharmacology. 42 (3): 598–605. doi:10.1038/npp.2016.153. PMC 5240175 . PMID 27531626.
Lesseur C, Diergaarde B, Olshan AF, Wünsch-Filho V, Ness AR, Liu G, Lacko M, Eluf-Neto J, Franceschi S, Lagiou P, Macfarlane GJ, Richiardi L, Boccia S, Polesel J, Kjaerheim K, Zaridze D, Johansson M, Menezes AM, Curado MP, Robinson M, Ahrens W, Canova C, Znaor A, Castellsagué X, Conway DI, Holcátová I, Mates D, Vilensky M, Healy CM, Szeszenia-Dąbrowska N, Fabiánová E, Lissowska J, Grandis JR, Weissler MC, Tajara EH, Nunes FD, de Carvalho MB, Thomas S, Hung RJ, Peters WH, Herrero R, Cadoni G, Bueno-de-Mesquita HB, Steffen A, Agudo A, Shangina O, Xiao X, Gaborieau V, Chabrier A, Anantharaman D, Boffetta P, Amos CI, McKay JD, Brennan P (December 2016). "Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer". Nat. Genet. 48 (12): 1544–1550. doi:10.1038/ng.3685. PMC 5131845 . PMID 27749845.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000107902 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030946 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Phospholysine phosphohistidine inorganic pyrophosphate phosphatase" . Retrieved 2018-07-14.

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Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Related Research Articles

References

Further reading