Placenta expressed transcript 1

PLET1
Identifiers
Aliases	PLET1 , C11orf34, placenta expressed transcript 1
External IDs	OMIM: 611904 MGI: 1923759 HomoloGene: 49928 GeneCards: PLET1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	112,260,860 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	50,416,782 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Achilles tendon; ; islet of Langerhans; ; gastric mucosa; ; right lung; ; anterior pituitary; ; right adrenal gland; ; small intestine; ; lymphatic system; ; gallbladder;
	Top expressed in
	submandibular gland; ; parotid gland; ; corneal stroma; ; lacrimal gland; ; epithelium of stomach; ; conjunctival fornix; ; uterus; ; prostate; ; lip; ; seminal vesicula;
	More reference expression data
	n/a
Orthologs
	349633
	76509
	ENSG00000188771
	ENSMUSG00000032068
	Q6UQ28
	Q8VEN2
	NM_001145024
	NM_029639
	NP_001138496
	NP_083915
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 01, 2023

Placenta expressed transcript 1 is a protein that in humans is encoded by the PLET1 gene. ^[5]

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RTL1 is a retrotransposon derived protein coding gene. It is also known as PEG11 and is a paternally expressed imprinted gene, part of genomic imprinting. RTL1 plays an important role in the maintenance of fetal capillaries and is expressed in high quantities during late stage of fetal development. The expression of this gene is important for the development of the placenta, the fetus-maternal interface. Because the placenta is the first organ to form during the development of an embryo, problems in its establishment and biological role lead to complications during gestation. This organ maintains the fetus throughout the pregnancy and is therefore sensitive to disruptions. Studies in mice suggest that disruption of the RTL1 concentration, whether increasing or decreasing the amount of this protein coding gene, can lead to serious errors in the conservation of placental fetal capillaries. RTL1 knockout mice have shown obstruction in fetal development along with late fetal/neonatal death. Studies from sheep homologs suggest that high expression levels of RTL1 can lead to skeletal muscle hypertrophy This is due to over-expression patterns in the paternal allele specific gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000188771 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032068 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Placenta expressed transcript 1" . Retrieved 2018-02-01.

Placenta expressed transcript 1

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References

Further reading