Plexin A1

PLXNA1
Identifiers
Aliases	PLXNA1 , NOV, NOVP, PLEXIN-A1, PLXN1, Plexin A1
External IDs	OMIM: 601055 MGI: 107685 HomoloGene: 56426 GeneCards: PLXNA1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	127,037,389 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	89,339,602 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; stromal cell of endometrium; ; Brodmann area 23; ; endothelial cell; ; sural nerve; ; Brodmann area 46; ; superior frontal gyrus; ; Region I of hippocampus proper; ; orbitofrontal cortex; ; entorhinal cortex;
	Top expressed in
	bronchus; ; lobar bronchus; ; lip; ; ascending aorta; ; secondary oocyte; ; internal carotid artery; ; molar; ; aortic valve; ; external carotid artery; ; cerebellar cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	semaphorin receptor activity ; signaling receptor activity ;
Cellular component	integral component of membrane ; membrane ; plasma membrane ; semaphorin receptor complex ; extracellular exosome ; integral component of plasma membrane ;
Biological process	regulation of axon extension involved in axon guidance ; neuron projection extension ; multicellular organism development ; neuron projection guidance ; branchiomotor neuron axon guidance ; dichotomous subdivision of terminal units involved in salivary gland branching ; regulation of smooth muscle cell migration ; semaphorin-plexin signaling pathway ; signal transduction ; negative regulation of cell adhesion ; regulation of cell shape ; regulation of cell migration ; regulation of GTPase activity ; positive regulation of axonogenesis ; semaphorin-plexin signaling pathway involved in axon guidance ;
	Sources:Amigo / QuickGO
Orthologs
	5361
	18844
	ENSG00000114554
	ENSMUSG00000030084
	Q9UIW2
	P70206
	NM_032242
	NM_008881
	NP_115618
	NP_032907
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Plexin-A1 is a protein that in humans is encoded by the PLXNA1 gene.^[5]^[6]

Interactions

Plexin A1 has been shown to interact with AKT1.^[7]

Related Research Articles

Semaphorins are a class of secreted and membrane proteins that were originally identified as axonal growth cone guidance molecules. They primarily act as short-range inhibitory signals and signal through multimeric receptor complexes. Semaphorins are usually cues to deflect axons from inappropriate regions, especially important in the neural system development. The major class of proteins that act as their receptors are called plexins, with neuropilins as their co-receptors in many cases. The main receptors for semaphorins are plexins, which have established roles in regulating Rho-family GTPases. Recent work shows that plexins can also influence R-Ras, which, in turn, can regulate integrins. Such regulation is probably a common feature of semaphorin signalling and contributes substantially to our understanding of semaphorin biology.

<span class="mw-page-title-main">Plexin</span> Protein

A plexin is a protein which acts as a receptor for semaphorin family signaling proteins. It is classically known for its expression on the surface of axon growth cones and involvement in signal transduction to steer axon growth away from the source of semaphorin. Plexin also has implications in development of other body systems by activating GTPase enzymes to induce a number of intracellular biochemical changes leading to a variety of downstream effects.

Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene.

Neuropilin-1 is a protein that in humans is encoded by the NRP1 gene. In humans, the neuropilin 1 gene is located at 10p11.22. This is one of two human neuropilins.

Semaphorin-3A is a protein that in humans is encoded by the SEMA3A gene.

Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.

Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.

Semaphorin-3F is a protein that in humans is encoded by the SEMA3F gene.

Rnd1 is a small signaling G protein, and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND1.

Semaphorin-3C is a protein that in humans is encoded by the SEMA3C gene.

Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.

Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.

Semaphorin 7A, GPI membrane anchor (SEMA7A) also known as CD108, is a human gene.

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.

Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.

Semaphorin-4B is a protein that in humans is encoded by the SEMA4B gene.

Plexin-D1 is a protein that in humans is encoded by the PLXND1 gene.

Plexin-A3 is a protein that in humans is encoded by the PLXNA3 gene.

Plexin-A4 is a protein that in humans is encoded by the PLXNA4 gene.

Semaphorin-4G is a protein that in humans is encoded by the SEMA4G gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000114554 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030084 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci U S A. 93 (2): 674–8. Bibcode:1996PNAS...93..674M. doi: 10.1073/pnas.93.2.674 . PMC 40111 . PMID 8570614.
↑ "Entrez Gene: PLXNA1 plexin A1".
↑ Turner, Laura J; Nicholls Sarah; Hall Alan (Aug 2004). "The activity of the plexin-A1 receptor is regulated by Rac". J. Biol. Chem. United States. 279 (32): 33199–205. doi: 10.1074/jbc.M402943200 . ISSN 0021-9258. PMID 15187088.

Takahashi T, Fournier A, Nakamura F, et al. (1999). "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors". Cell. 99 (1): 59–69. doi: 10.1016/S0092-8674(00)80062-8 . PMID 10520994. S2CID 18167425.
Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi: 10.1016/S0092-8674(00)80063-X . PMID 10520995. S2CID 17386412.
Rohm B, Rahim B, Kleiber B, et al. (2001). "The semaphorin 3A receptor may directly regulate the activity of small GTPases". FEBS Lett. 486 (1): 68–72. doi: 10.1016/S0014-5793(00)02240-7 . PMID 11108845. S2CID 7914214.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Takahashi T, Strittmatter SM (2001). "Plexina1 autoinhibition by the plexin sema domain". Neuron. 29 (2): 429–39. doi: 10.1016/S0896-6273(01)00216-1 . PMID 11239433. S2CID 2487482.
Zanata SM, Hovatta I, Rohm B, Püschel AW (2002). "Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse". J. Neurosci. 22 (2): 471–7. doi:10.1523/JNEUROSCI.22-02-00471.2002. PMC 6758682 . PMID 11784792.
Mitsui N, Inatome R, Takahashi S, et al. (2002). "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling". EMBO J. 21 (13): 3274–85. doi:10.1093/emboj/cdf328. PMC 125392 . PMID 12093729.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Usui H, Taniguchi M, Yokomizo T, Shimizu T (2003). "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains". Biochem. Biophys. Res. Commun. 300 (4): 927–31. doi:10.1016/S0006-291X(02)02966-2. PMID 12559962.
Bachelder RE, Lipscomb EA, Lin X, et al. (2003). "Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells". Cancer Res. 63 (17): 5230–3. PMID 14500350.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Toyofuku T, Zhang H, Kumanogoh A, et al. (2004). "Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2". Genes Dev. 18 (4): 435–47. doi:10.1101/gad.1167304. PMC 359397 . PMID 14977921.
Turner LJ, Nicholls S, Hall A (2004). "The activity of the plexin-A1 receptor is regulated by Rac". J. Biol. Chem. 279 (32): 33199–205. doi: 10.1074/jbc.M402943200 . PMID 15187088.
Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. Bibcode:2006Natur.440.1194M. doi: 10.1038/nature04728 . PMID 16641997.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000114554 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030084 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8570614-5] Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci U S A. 93 (2): 674–8. Bibcode:1996PNAS...93..674M. doi: 10.1073/pnas.93.2.674 . PMC 40111 . PMID 8570614.

[entrez-6] "Entrez Gene: PLXNA1 plexin A1".

[pmid15187088-7] Turner, Laura J; Nicholls Sarah; Hall Alan (Aug 2004). "The activity of the plexin-A1 receptor is regulated by Rac". J. Biol. Chem. United States. 279 (32): 33199–205. doi: 10.1074/jbc.M402943200 . ISSN 0021-9258. PMID 15187088.

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Plexin A1

Contents

Interactions

Related Research Articles

References

Further reading