Protein BEX1

BEX1
Identifiers
Aliases	BEX1 , BEX2, HBEX2, HGR74-h, brain expressed X-linked 1
External IDs	OMIM: 300690; MGI: 1338017; HomoloGene: 135613; GeneCards: BEX1; OMA:BEX1 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq22.1|Xq22 Start 103,062,651 bp [1] End 103,064,171 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X F1|X 57.37 cM Start 134,967,313 bp [2] End 134,968,985 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus orbitofrontal cortex primary visual cortex dorsolateral prefrontal cortex superior frontal gyrus Brodmann area 9 prefrontal cortex pituitary gland Top expressed in arcuate nucleus ventromedial nucleus paraventricular nucleus of hypothalamus temporal lobe amygdala dorsomedial hypothalamic nucleus lateral septal nucleus anterior amygdaloid area lateral hypothalamus median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm nucleus transcription regulator complex Biological process multicellular organism development cell differentiation positive regulation of DNA-binding transcription factor activity nervous system development positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55859 12069 Ensembl ENSG00000133169 ENSMUSG00000042750 UniProt Q9HBH7 Q9WTZ8 RefSeq (mRNA) NM_018476 NM_009749 RefSeq (protein) NP_060946 NP_033879 Location (UCSC) Chr X: 103.06 – 103.06 Mb Chr X: 134.97 – 134.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein BEX1 also known as brain-expressed X-linked protein 1 is a protein that in humans is encoded by the BEX1 gene. ^[5] BEX1 is apart of the BEX gene family well conserved in mammals. It is expressed in a wide range of tissues. ^[6] BEX proteins have connections to cancer and their direct functions are not fully understood. BEX1 is suggested to act as a tumor suppresant in certain situations. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000133169 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042750 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: BEX1 brain expressed, X-linked 1".
6. Kazi, Julhash U.; Kabir, Nuzhat N.; Rönnstrand, Lars (December 2015). "Brain-Expressed X-linked (BEX) proteins in human cancers". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1856 (2): 226–233. doi:10.1016/j.bbcan.2015.09.001.

Further reading

• Foltz G, Ryu GY, Yoon JG, et al. (2006). "Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma". Cancer Res. 66 (13): 6665–74. doi: 10.1158/0008-5472.CAN-05-4453 . PMID   16818640.
• Alvarez E, Zhou W, Witta SE, Freed CR (2005). "Characterization of the Bex gene family in humans, mice, and rats". Gene. 357 (1): 18–28. doi:10.1016/j.gene.2005.05.012. PMID   15958283.
• Quentmeier H, Tonelli R, Geffers R, et al. (2005). "Expression of BEX1 in acute myeloid leukemia with MLL rearrangements". Leukemia. 19 (8): 1488–9. doi: 10.1038/sj.leu.2403820 . PMID   15920485.
• Baldisseri DM, Margolis JW, Weber DJ, et al. (2002). "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction". J. Mol. Biol. 319 (3): 823–37. doi:10.1016/S0022-2836(02)00282-6. PMID   12054873.
• Yang QS, Xia F, Gu SH, et al. (2002). "Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22". Biochem. Genet. 40 (1–2): 1–12. doi:10.1023/A:1014565320998. PMID   11989783. S2CID   24146602.