Protein geranylgeranyltransferase type I subunit beta

PGGT1B
Identifiers
Aliases	PGGT1B , BGGI, GGTI, protein geranylgeranyltransferase type I subunit beta
External IDs	OMIM: 602031; MGI: 1917514; HomoloGene: 3685; GeneCards: PGGT1B; OMA:PGGT1B - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	115,262,877 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	46,414,060 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; monocyte; ; palpebral conjunctiva; ; mucosa of sigmoid colon; ; Achilles tendon; ; rectum; ; islet of Langerhans; ; amniotic fluid; ; epithelium of colon;
	Top expressed in
	hand; ; otolith organ; ; utricle; ; pineal gland; ; renal corpuscle; ; prostate; ; lobe of prostate; ; otic vesicle; ; foot; ; lacrimal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	prenyltransferase activity ; zinc ion binding ; protein geranylgeranyltransferase activity ; metal ion binding ; catalytic activity ; isoprenoid binding ; peptide binding ; transferase activity ; CAAX-protein geranylgeranyltransferase activity ;
Cellular component	CAAX-protein geranylgeranyltransferase complex ;
Biological process	negative regulation of nitric-oxide synthase biosynthetic process ; positive regulation of cell cycle ; positive regulation of cell population proliferation ; response to cytokine ; protein geranylgeranylation ; protein prenylation ;
	Sources:Amigo / QuickGO
Orthologs
	5229
	225467
	ENSG00000164219
	ENSMUSG00000024477
	P53609
	Q8BUY9
	NM_005023
	NM_172627
	NP_005014
	NP_766215
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 26, 2024

Protein geranylgeranyltransferase type I subunit beta is a protein that in humans is encoded by the PGGT1B gene.^[5]

Function

Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010].

Related Research Articles

Geranylgeranyltransferase type 1 or simply geranylgeranyltransferase is one of the three enzymes in the prenyltransferase group. In specific terms, Geranylgeranyltransferase adds a 20-carbon isoprenoid called a geranylgeranyl group to proteins bearing a CaaX motif: a four-amino acid sequence at the carboxyl terminal of a protein. Geranylgeranyltransferase inhibitors are being investigated as anti-cancer agents.

Rab geranylgeranyltransferase also known as (protein) geranylgeranyltransferase II is one of the three prenyltransferases. It transfers (usually) two geranylgeranyl groups to the cystein(s) at the C-terminus of Rab proteins.

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

Rab escort protein 1 (REP1) also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene.

Hypoxia-inducible factor 3 alpha is a protein that in humans is encoded by the HIF3A gene.

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5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha is an enzyme that in humans is encoded by the FNTA gene.

Neuronal acetylcholine receptor subunit beta-4 is a protein that in humans is encoded by the CHRNB4 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene.

Protein farnesyltransferase subunit beta is an enzyme that in humans is encoded by the FNTB gene.

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene.

Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene.

Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene.

Large ribosomal subunit protein uL14 is a protein that in humans is encoded by the RPL23 gene.

Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22.2

Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene.

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.

Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene. ATP1B3 has also been designated as CD298.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164219 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024477 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Protein geranylgeranyltransferase type I subunit beta" . Retrieved 2018-09-21.

Kusama T, Mukai M, Tatsuta M, Matsumoto Y, Nakamura H, Inoue M (2003). "Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor". Clin. Exp. Metastasis. 20 (6): 561–7. doi:10.1023/a:1025898316728. PMID 14598891. S2CID 24756418.
Reid TS, Terry KL, Casey PJ, Beese LS (October 2004). "Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity". J. Mol. Biol. 343 (2): 417–33. doi:10.1016/j.jmb.2004.08.056. PMID 15451670.
Comabella M, Craig DW, Morcillo-Suárez C, Río J, Navarro A, Fernández M, Martin R, Montalban X (August 2009). "Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis". Arch. Neurol. 66 (8): 972–8. doi: 10.1001/archneurol.2009.150 . PMID 19667218.
Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB (May 2010). "Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer". Cancer Prev Res (Phila). 3 (5): 597–603. doi: 10.1158/1940-6207.CAPR-10-0007 . PMID 20403997.
Virtanen SS, Sandholm J, Yegutkin G, Kalervo Väänänen H, Härkönen PL (August 2010). "Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells". Cell Biol. Int. 34 (8): 815–26. doi:10.1042/CBI20090288. PMID 20446922. S2CID 44993117.
Ghavami S, Mutawe MM, Schaafsma D, Yeganeh B, Unruh H, Klonisch T, Halayko AJ (February 2012). "Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle". Am. J. Physiol. Lung Cell Mol. Physiol. 302 (4): L420–8. doi:10.1152/ajplung.00312.2011. PMID 22160308. S2CID 13448673.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164219 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024477 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Protein geranylgeranyltransferase type I subunit beta" . Retrieved 2018-09-21.

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Protein geranylgeranyltransferase type I subunit beta

Contents

Function

Related Research Articles

References

Further reading