Psora-4

Last updated

Psora-4
Psora-4 structure.png
Identifiers
  • 4-(4-phenylbutoxy)furo[3,2-g]chromen-7-one
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C21H18O4
Molar mass 334.371 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)CCCCOC2=C3C=CC(=O)OC3=CC4=C2C=CO4
  • InChI=1S/C21H18O4/c22-20-10-9-16-19(25-20)14-18-17(11-13-23-18)21(16)24-12-5-4-8-15-6-2-1-3-7-15/h1-3,6-7,9-11,13-14H,4-5,8,12H2
  • Key:JJAWGNIQEOFURP-UHFFFAOYSA-N

Psora-4 is an experimental drug that acts as a selective inhibitor of the Kv1.3 potassium channel. It has immunomodulatory effects, suppressing the proliferation of memory T cells, but increases neural progenitor cell proliferation and has lifespan-extending effects in animal studies. [1] [2] [3] [4] [5] [6] [7] [8]

References

  1. ↑ Vennekamp J, Wulff H, Beeton C, Calabresi PA, Grissmer S, Hänsel W, et al. (June 2004). "Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators". Molecular Pharmacology. 65 (6): 1364–1374. doi:10.1124/mol.65.6.1364. PMID   15155830.
  2. ↑ Liebau S, Pröpper C, Böckers T, Lehmann-Horn F, Storch A, Grissmer S, et al. (October 2006). "Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferation". Journal of Neurochemistry. 99 (2): 426–437. doi:10.1111/j.1471-4159.2006.03967.x. PMID   17029597.
  3. ↑ Hyodo T, Oda T, Kikuchi Y, Higashi K, Kushiyama T, Yamamoto K, et al. (December 2010). "Voltage-gated potassium channel Kv1.3 blocker as a potential treatment for rat anti-glomerular basement membrane glomerulonephritis". American Journal of Physiology. Renal Physiology. 299 (6): F1258 –F1269. doi:10.1152/ajprenal.00374.2010. PMC   3006300 . PMID   20810612.
  4. ↑ Ueyama A, Imura K, Kasai-Yamamoto E, Tai N, Nagira M, Shichijo M, et al. (December 2013). "Kv1.3 blockers ameliorate allergic contact dermatitis by preferentially suppressing effector memory T cells in a rat model". Clinical and Experimental Dermatology. 38 (8): 897–903. doi:10.1111/ced.12097. PMID   24252082.
  5. ↑ Zhou YY, Hou GQ, He SW, Xiao Z, Xu HJ, Qiu YT, et al. (July 2015). "Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells". CNS Neuroscience & Therapeutics. 21 (7): 558–567. doi:10.1111/cns.12402. PMC   6495590 . PMID   25976092.
  6. ↑ Admasu TD, Chaithanya Batchu K, Barardo D, Ng LF, Lam VY, Xiao L, et al. (October 2018). "Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling". Developmental Cell. 47 (1): 67–79.e5. doi: 10.1016/j.devcel.2018.09.001 . PMID   30269951.
  7. ↑ Admasu TD, Barardo D, Ng LF, Batchu KC, Cazenave-Gassiot A, Wenk MR, et al. (April 2022). "A small-molecule Psora-4 acts as a caloric restriction mimetic to promote longevity in C. elegans". GeroScience. 44 (2): 1029–1046. doi:10.1007/s11357-021-00374-6. PMC   9135947 . PMID   33988831.
  8. ↑ Sastre D, Colomer-Molera M, de Benito-Bueno A, Valenzuela C, Fernández-Ballester G, Felipe A (August 2024). "KCNE4-dependent modulation of Kv1.3 pharmacology". Biochemical Pharmacology. 226: 116368. doi:10.1016/j.bcp.2024.116368. hdl: 10261/363770 . PMID   38880360.
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