Puerto Rico Highway 3(PR-3) at nearly 100 miles long, is the second-longest highway on Puerto Rico. It connects the San Juan neighborhood of Río Piedras to downtown Salinas indirectly around the eastern coast of the island. Highway 3 ranges from a three lane urban avenue in San Juan to a one lane rural road past Fajardo. While other roads connect San Juan, it runs the coastline of Puerto Rico east of San Juan, beginning in Río Piedras near Santurce and goes to Fajardo where it goes south paralleling the coastline to Humacao and Maunabo. It goes up to a mountain-scenic route and goes west to Salinas, where it meets PR-1.
Puerto Rico Highway 1 (PR-1) is a highway in Puerto Rico that connects the city of Ponce to San Juan. Leaving Ponce, the road heads east and follows a somewhat parallel route along the southern coast of the island heading towards Salinas. At Salinas, the road turns north to cut through the Cordillera Central in its approach to San Juan. Before reaching San Juan, it climbs to make its way to the mountain town of Cayey and then it winds down into the city of Caguas on its final approach to San Juan.
Puerto Rico Highway 115 (PR-115) is a highway which follows the west coastline of Puerto Rico from south Añasco at PR-2 to near downtown Aguadilla, where it becomes Puerto Rico Highway 111 after intersecting PR-2 again, and is the primary route to the town of Rincón, Puerto Rico, a tourist and frequent destination of surfers.
Puerto Rico Highway 111 (PR-111) is a highway connecting Aguadilla, Puerto Rico at Puerto Rico Highway 2 and Puerto Rico Highway 115 to Utuado, Puerto Rico at Puerto Rico Highway 140.
Puerto Rico Highway 54 (PR-54) is a short divided highway located in Guayama, Puerto Rico and is mainly a by-pass route from Puerto Rico Highway 3 out of Downtown Guayama to Puerto Rico Highway 53. The government of Puerto Rico named the stretch of highway that extends from PR-54, in Guayama, to PR-52, in Salinas Autopista José M. Dávila Monsanto in honor of the late Puerto Rican political leader José M. Dávila Monsanto.
Puerto Rico Highway 65 (PR-65) is a short highway connecting Puerto Rico Highway PR-239, also locally known as Alfonso Valdés Cobián Boulevard near University of Puerto Rico at Mayagüez, to Puerto Rico Highway 106. It has not an intersection to the main highway PR-2, but can be accessed quickly going west of the alt route. It is also the main highway to the Palacio de Recreación y Deportes and to the Parque de los Próceres.
Puerto Rico Highway 14 (PR-14) is a main highway connecting Ponce to Cayey, Puerto Rico. The road runs the same course as the historic Carretera Central. The Ponce-to-Coamo section of PR-14 was built under the direction of Spanish engineer Raimundo Camprubí Escudero.
Puerto Rico Highway 102 (PR-102) is a main highway in the southwestern portion of the Porta del Sol region of Puerto Rico. It begins at Puerto Rico Highway 2 north of central Mayagüez and runs through the municipalities of Cabo Rojo and San Germán, coming to an end in downtown Sabana Grande.
Puerto Rico Highway 29 (PR-29) is an avenue in the city of Bayamón, Puerto Rico. It connects from the PR-2 to the PR-5, intersects the PR-167 at Plaza del Sol. This road is called Avenida Main Oeste.
Puerto Rico Highway 47 (PR-47), also known as Calle De Diego, is an urban road in Río Piedras, Puerto Rico.
Puerto Rico Highway 37 (PR-37) is an urban road between San Juan and Carolina. In Santurce is known as Calle Loíza and the Isla Verde area is known as Avenida Isla Verde.
Puerto Rico Highway 35 (PR-35), also known as Avenida Manuel Fernández Juncos, is an urban road in San Juan, Puerto Rico.
Puerto Rico Highway 136 (PR-136) is a short road in Guayanilla, Puerto Rico.
Puerto Rico Highway 130 (PR-130) is the main north–south route within the municipality of Hatillo, Puerto Rico.
Puerto Rico Highway 27 (PR-27) is a north–south avenue located in San Juan, Puerto Rico, known as Avenida José Celso Barbosa. This highway extends from Avenida 65 de Infantería (PR-3) to Avenida Borinquen (PR-36) in Santurce, east of downtown Río Piedras and Hato Rey.
Puerto Rico Highway 722 (PR-722) is a rural road located in Aibonito, Puerto Rico. It begins at its intersection with PR-14 east of downtown Aibonito and ends at the Ruta Panorámica between Robles and Pasto barrios. The traditional Festival de las Flores is celebrated near this road.
Puerto Rico Highway 24 (PR-24) is a north–south road located between the municipalities of Cataño and Guaynabo, Puerto Rico. This highway extends from Avenida Las Nereidas (PR-888) in downtown Cataño to Avenida El Caño (PR-165) near the Metropolitan Detention Center, Guaynabo. In Cataño, it is known as Calle Wilson, and in Guaynabo, as Avenida Juan Ponce de León.
Puerto Rico Highway 107 (PR-107), or Carretera Pedro Albizu Campos, is a north–south highway located in Aguadilla, Puerto Rico. It extends from PR-2 to Ramey Air Force Base.
Puerto Rico Highway 152 (PR-152) is a rural road that travels from Barranquitas to Naranjito in Puerto Rico. This road extends from PR-156 in downtown Barranquitas and ends at its junction with PR-5 and PR-164 near downtown Naranjito.
Puerto Rico Highway 888 (PR-888) is a road located in Cataño, Puerto Rico. It goes from PR-165 in Palmas barrio to downtown Cataño, bordering San Juan Bay until its end at PR-5 in La Puntilla sector. The entire route is known as Avenida Las Nereidas.
PR-701 in Río Jueyes 
PR-3 in Aguirre 
PR-1 / PR-52 in Salinas barrio-pueblo 
