Puerto Rico Highway 52 (PR-52), a major toll road in Puerto Rico, is also known as Autopista Luis A. Ferré. It was formerly called Expreso Las Américas. It runs from PR-1 in southwest Río Piedras and heads south until it intersects with highway PR-2 in Ponce. At its north end, the short PR-18 continues north from PR-52 towards San Juan. This short segment is known as Expreso Las Américas, the only segment of the route still unofficially bearing this name, since PR-18 is officially named Roberto Sánchez Vilella Expressway. The combined route of PR-18 and PR-52 runs concurrent with the unsigned Interstate Highway PRI-1. Toll stations are located in San Juan, Caguas, Salinas, Juana Díaz, and Ponce.
Puerto Rico Highway 1 (PR-1) is a highway in Puerto Rico that connects the city of Ponce to San Juan. Leaving Ponce, the road heads east and follows a somewhat parallel route along the southern coast of the island heading towards Salinas. At Salinas, the road turns north to cut through the Cordillera Central in its approach to San Juan. Before reaching San Juan, it climbs to make its way to the mountain town of Cayey and then it winds down into the city of Caguas on its final approach to San Juan.
Puerto Rico Highway 53 (PR-53) or unsigned Interstate PR3 is a main tollway that is parallel to Puerto Rico Highway 3, which goes from Fajardo to Salinas. Some segments are still in planning, but when finished it will be about 58 miles (93 km) in length. Two tunnels, about 0.6 mi (1 km) long each, in the towns of Yabucoa and Maunabo were completed in October 2008. It will connect the cities of Fajardo, Ceiba, Naguabo, Humacao, Yabucoa, Maunabo, Patillas, Arroyo, Guayama and Salinas, thus bordering the entire eastern and southeastern coasts of Puerto Rico. Its northern terminus is at PR-3 and PR-194 in Fajardo, and its south terminus is at PR-52 in Salinas.
Puerto Rico Highway 20 (PR-20) or Expreso Rafael Martínez Nadal is a short tollway located entirely in the municipality of Guaynabo, Puerto Rico.
Puerto Rico Highway 26 (PR-26), called the Román Baldorioty de Castro Expressway, is the main highway to the Luis Muñoz Marín International Airport and is connected to PR-66. It was converted to a freeway to minimize the traffic in PR-3 and PR-17, to grant better access to the Airport. Several exits exist to provide access to PR-187, PR-37 and PR-22. PR-26 is 15.1 km (9.4 mi) long.
Puerto Rico Highway 15 (PR-15) is a main highway connecting Cayey and Guayama. It takes longer though, than going south to Salinas through PR-52 and taking PR-53 to Guayama, due to it being a rural road.
Puerto Rico Highway 177 (PR-177) is a main highway connecting the area of Cupey, San Juan, Puerto Rico to Bayamón, Puerto Rico. It passes through Guaynabo in the area known as Torrimar. It is divided in all of its length. In Bayamón, it ends in the intersection to Puerto Rico Highway 174 and Main Road, which connects to Puerto Rico Highway 2. In Cupey, it ends at Puerto Rico Highway 176.
Puerto Rico Highway 17 (PR-17) is a main highway located in Carolina, San Juan and Guaynabo, Puerto Rico. It begins at PR-20 near its terminus with PR-2, and ends in the Luis Muñoz Marín International Airport in Carolina. It is known as Jesus de Piñero Avenue along its entire length.
Puerto Rico Highway 184 (PR-184) is a main, rural highway that connects Patillas to Cayey, Puerto Rico, with plans to be extended to Cidra. Sometimes referred to as Pork Highway, it is the main and only access to the various famous roasted-pork restaurants in the area of Guavate and the access to the Carite State Forest. It borders the Guavate or Carite River, where several people swim often, and like Puerto Rico Highway 181, it borders the man-made Carite Lake, and it meets its end at Puerto Rico Highway 3. The main antennas of the local TV stations Telemundo, WAPA-TV and Univision can be seen from this road in La Santa. The road passes near a point where five municipalities share a border – Cayey, Patillas, San Lorenzo, Caguas and Guayama.
The Ruta Panorámica, officially the Ruta Panorámica Luis Muñoz Marín, is a 167-mile (269 km) network of some 40 secondary roads which traverse the island of Puerto Rico from west to east along its Cordillera Central. Most of the route consists of three roads, PR-105, PR-143, and PR-182. The route starts in Mayagüez and ends in Maunabo. The first major segment of the route runs from Mayagüez to Maricao as Route 105, then from Adjuntas to Aibonito as Route 143, and then follows Route 182 toward Maunabo.
Puerto Rico Highway 47 (PR-47), also known as Calle De Diego, is an urban road in Río Piedras, Puerto Rico.
Puerto Rico Highway 37 (PR-37) is an urban road between San Juan and Carolina. In Santurce is known as Calle Loíza and the Isla Verde area is known as Avenida Isla Verde.
Puerto Rico Highway 735 (PR-735) is a rural road located between the municipalities of Cayey and Cidra, Puerto Rico, and it corresponds to an original segment of the historic Carretera Central. The Arenas and La Liendre old bridges are located on this route.
Puerto Rico Highway 715 (PR-715) is a rural road located in Cayey, Puerto Rico. This highway extends from PR-1 between Matón Arriba and Sumido barrios to Cercadillo.
Puerto Rico Highway 693 (PR-693) is a road located between the municipalities of Dorado, Puerto Rico and Vega Alta, passing through downtown Dorado. It begins at its intersection with PR-2 and PR-165 in Río Lajas and ends at PR-690 in Sabana. It is a short divided highway in southern Dorado, which serves as an alternate route for PR-165 west of Río de la Plata.
Puerto Rico Highway 722 (PR-722) is a rural road located in Aibonito, Puerto Rico. It begins at its intersection with PR-14 east of downtown Aibonito and ends at the Ruta Panorámica between Robles and Pasto barrios. The traditional Festival de las Flores is celebrated near this road.
Puerto Rico Highway 179 (PR-179) is a rural road that travels from Guayama to Cayey in Puerto Rico. It goes through Patillas but with no major junctions. This road extends from PR-15 north of downtown Guayama and ends at PR-184 in Farallón.
Puerto Rico Highway 171 (PR-171) is a road that travels from Cidra, Puerto Rico to Cayey. It begins at its intersection with PR-172 in downtown Cidra and ends at its junction with PR-14 near downtown Cayey.
Puerto Rico Highway 170 (PR-170) is a road located in Cayey, Puerto Rico. This highway begins at its intersection with PR-14 and PR-731 in downtown Cayey and ends at its junction with PR-1 and PR-206 in Matón Arriba.
Puerto Rico Highway 200 (PR-200) is a road located in Vieques, Puerto Rico. This highway extends from Mosquito to Puerto Diablo, passing through Isabel II.
PR-1 in Matón Arriba 
PR-170 in Matón Arriba
PR-14 in Cayey barrio-pueblo 
