RAB11FIP1

RAB11FIP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D0G
Identifiers
Aliases	RAB11FIP1 , NOEL1A, RCP, rab11-FIP1, RAB11 family interacting protein 1
External IDs	OMIM: 608737 MGI: 1923017 HomoloGene: 11853 GeneCards: RAB11FIP1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	37,899,497 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	27,664,674 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; amniotic fluid; ; bronchial epithelial cell; ; cavity of mouth; ; islet of Langerhans; ; jejunal mucosa; ; rectum; ; duodenum; ; blood; ; palpebral conjunctiva;
	Top expressed in
	lip; ; secondary oocyte; ; esophagus; ; morula; ; jejunum; ; stomach; ; duodenum; ; colon; ; right lung lobe; ; yolk sac;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; recycling endosome ; endosome ; phagocytic vesicle membrane ; membrane ; cytoplasmic vesicle ; cytosol ; intracellular membrane-bounded organelle ;
Biological process	protein transport ; regulated exocytosis ; negative regulation of adiponectin secretion ;
	Sources:Amigo / QuickGO
Orthologs
	80223
	75767
	ENSG00000156675
	ENSMUSG00000031488
	Q6WKZ4
	Q9D620
	NM_025151 ; NM_001002233 ; NM_001002814
	NM_001080813 ; NM_029423
	NP_001002814 ; NP_079427
	NP_001074282 ; NP_083699
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2023

Rab11 family-interacting protein 1 (Rab11-FIP1) also known as Rab-coupling protein is a protein that in humans is encoded by the RAB11FIP1 gene.^[5]^[6]^[7]

Function

Proteins of the large Rab GTPase family (see for example RAB1A) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of many proteins that interact with and regulate Rab GTPases.^[6]^[7] RAB11FIP1 has been identified as a novel protein involved in the regulation of adiponectin trafficking and release from the adipocyte.^[8] RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte, potentially contributing to lower circulating levels of adiponectin observed in obese populations.^[8]

Interactions

RAB11FIP1 has been shown to interact with RAB11A ^[5]^[6]^[9] and RAB4A.^[5]

Related Research Articles

Dynamin-2 is a protein that in humans is encoded by the DNM2 gene.

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene.

Ras-related protein Rab-4A is a protein that in humans is encoded by the RAB4A gene.

The alpha-1B adrenergic receptor (α_1B-adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it. The crystal structure of the α_1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.

Bcl-2-related protein A1 is a protein in humans which is encoded by the BCL2A1 gene.

Protein phosphatase 1 regulatory subunit 15A, also known as growth arrest and DNA damage-inducible protein (GADD34), is a protein that in humans is encoded by the PPP1R15A gene.

HMG-box transcription factor 1, also known as HBP1, is a human protein.

Rab11 family-interacting protein 2 is a protein that in humans is encoded by the RAB11FIP2 gene.

Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.

Rab11 family-interacting protein 5 is a protein that in humans is encoded by the RAB11FIP5 gene.

Rab11 family-interacting protein 3 is a protein that in humans is encoded by the RAB11FIP3 gene.

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.

Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene.

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.

ATP-binding cassette sub-family F member 1 is a protein that in humans is encoded by the ABCF1 gene.

Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene. It is thought to act as a promoter of tumor development.

Rab11 family-interacting protein 4 is a protein that in humans is encoded by the RAB11FIP4 gene.

Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.

AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene.

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene. It is the homolog of the C. elegans and D. melanogaster gene SPD-2.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000156675 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031488 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW (Apr 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". J Biol Chem. 277 (14): 12190–9. doi: 10.1074/jbc.M108665200 . PMID 11786538.
1 2 3 Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR (Oct 2001). "Identification and characterization of a family of Rab11-interacting proteins". J Biol Chem. 276 (42): 39067–75. doi: 10.1074/jbc.M104831200 . PMID 11495908.
1 2 "Entrez Gene: RAB11FIP1 RAB11 family interacting protein 1 (class I)".
1 2 Carson, Brian P.; Maria Del Bas, Josep; Moreno-Navarrete, Jose Maria; Fernandez-Real, Jose Manuel; Mora, Silvia (September 2013). "The Rab11 Effector Protein FIP1 Regulates Adiponectin". PLOS ONE. 8 (9): e74687. doi: 10.1371/journal.pone.0074687 . PMC 3770573 . PMID 24040321.
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2002). "The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities". Biochem. Biophys. Res. Commun. 292 (4): 909–15. doi:10.1006/bbrc.2002.6736. PMID 11944901.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Thériault C, Rochdi MD, Parent JL (2004). "Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta)". Biochemistry. 43 (19): 5600–7. doi:10.1021/bi036268v. PMID 15134434.
Peden AA, Schonteich E, Chun J, et al. (2005). "The RCP-Rab11 complex regulates endocytic protein sorting". Mol. Biol. Cell. 15 (8): 3530–41. doi:10.1091/mbc.E03-12-0918. PMC 491816 . PMID 15181150.
Lindsay AJ, McCaffrey MW (2004). "Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis". FEBS Lett. 571 (1–3): 86–92. doi:10.1016/j.febslet.2004.06.068. PMID 15280022. S2CID 35306314.
Damiani MT, Pavarotti M, Leiva N, et al. (2005). "Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment". Traffic. 5 (10): 785–97. doi: 10.1111/j.1600-0854.2004.00220.x . PMID 15355514. S2CID 37310957.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Marie N, Lindsay AJ, McCaffrey MW (2005). "Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner". Biochem. J. 389 (Pt 1): 223–31. doi:10.1042/BJ20042116. PMC 1184555 . PMID 15769254.
Tajika Y, Matsuzaki T, Suzuki T, et al. (2006). "Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments". Histochem. Cell Biol. 124 (1): 1–12. doi:10.1007/s00418-005-0010-3. PMID 16049696. S2CID 14746792.
Patil VS, Sachdeva G, Modi DN, et al. (2006). "Rab coupling protein (RCP): a novel target of progesterone action in primate endometrium". J. Mol. Endocrinol. 35 (2): 357–72. doi: 10.1677/jme.1.01807 . PMID 16216915.
Jin M, Goldenring JR (2006). "The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system". Biochim. Biophys. Acta. 1759 (6): 281–95. doi:10.1016/j.bbaexp.2006.06.001. PMID 16920206.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000156675 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031488 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11786538-5] 1 2 3 Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW (Apr 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". J Biol Chem. 277 (14): 12190–9. doi: 10.1074/jbc.M108665200 . PMID 11786538.

[pmid11495908-6] 1 2 3 Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR (Oct 2001). "Identification and characterization of a family of Rab11-interacting proteins". J Biol Chem. 276 (42): 39067–75. doi: 10.1074/jbc.M104831200 . PMID 11495908.

[entrez-7] 1 2 "Entrez Gene: RAB11FIP1 RAB11 family interacting protein 1 (class I)".

[ncbi.nlm.nih.gov-8] 1 2 Carson, Brian P.; Maria Del Bas, Josep; Moreno-Navarrete, Jose Maria; Fernandez-Real, Jose Manuel; Mora, Silvia (September 2013). "The Rab11 Effector Protein FIP1 Regulates Adiponectin". PLOS ONE. 8 (9): e74687. doi: 10.1371/journal.pone.0074687 . PMC 3770573 . PMID 24040321.

[pmid17353931-9] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

RAB11FIP1

Contents

Function

Interactions

Related Research Articles

References

Further reading