RAB11FIP1

RAB11FIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D0G
Identifiers
Aliases	RAB11FIP1 , NOEL1A, RCP, rab11-FIP1, RAB11 family interacting protein 1
External IDs	OMIM: 608737; MGI: 1923017; HomoloGene: 11853; GeneCards: RAB11FIP1; OMA:RAB11FIP1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p11.23 Start 37,858,618 bp [1] End 37,899,497 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 A2 Start 27,628,801 bp [2] End 27,664,674 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung amniotic fluid bronchial epithelial cell oral cavity islet of Langerhans jejunal mucosa mucosa of ileum mucosa of colon mucosa of sigmoid colon nasal epithelium Top expressed in granulocyte zygote tail of embryo lip secondary oocyte esophagus primary oocyte morula jejunum stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm recycling endosome endosome phagocytic vesicle membrane membrane cytoplasmic vesicle cytosol intracellular membrane-bounded organelle Biological process protein transport regulated exocytosis negative regulation of adiponectin secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80223 75767 Ensembl ENSG00000156675 ENSMUSG00000031488 UniProt Q6WKZ4 Q9D620 RefSeq (mRNA) NM_025151 NM_001002233 NM_001002814 NM_001080813 NM_029423 RefSeq (protein) NP_001002814 NP_079427 NP_001074282 NP_083699 Location (UCSC) Chr 8: 37.86 – 37.9 Mb Chr 8: 27.63 – 27.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rab11 family-interacting protein 1 (Rab11-FIP1) also known as Rab-coupling protein is a protein that in humans is encoded by the RAB11FIP1 gene. ^{[5] [6] [7]}

Function

Proteins of the large Rab GTPase family (see for example RAB1A) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of many proteins that interact with and regulate Rab GTPases. ^{[6] [7]} RAB11FIP1 has been identified as a novel protein involved in the regulation of adiponectin trafficking and release from the adipocyte. ^[8] RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte, potentially contributing to lower circulating levels of adiponectin observed in obese populations. ^[8]

Interactions

RAB11FIP1 has been shown to interact with RAB11A ^{[5] [6] [9]} and RAB4A. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000156675 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031488 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW (Apr 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". J Biol Chem. 277 (14): 12190–9. doi: 10.1074/jbc.M108665200 . PMID   11786538.
6. Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR (Oct 2001). "Identification and characterization of a family of Rab11-interacting proteins". J Biol Chem. 276 (42): 39067–75. doi: 10.1074/jbc.M104831200 . PMID   11495908.
7. "Entrez Gene: RAB11FIP1 RAB11 family interacting protein 1 (class I)".
8. Carson, Brian P.; Maria Del Bas, Josep; Moreno-Navarrete, Jose Maria; Fernandez-Real, Jose Manuel; Mora, Silvia (September 2013). "The Rab11 Effector Protein FIP1 Regulates Adiponectin". PLOS ONE. 8 (9) e74687. doi: 10.1371/journal.pone.0074687 . PMC   3770573 . PMID   24040321.
9. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

Further reading

• Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2002). "The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities". Biochem. Biophys. Res. Commun. 292 (4): 909–15. doi:10.1006/bbrc.2002.6736. PMID   11944901.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Thériault C, Rochdi MD, Parent JL (2004). "Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta)". Biochemistry. 43 (19): 5600–7. doi:10.1021/bi036268v. PMID   15134434.
• Peden AA, Schonteich E, Chun J, et al. (2005). "The RCP-Rab11 complex regulates endocytic protein sorting". Mol. Biol. Cell. 15 (8): 3530–41. doi:10.1091/mbc.E03-12-0918. PMC   491816 . PMID   15181150.
• Lindsay AJ, McCaffrey MW (2004). "Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis". FEBS Lett. 571 (1–3): 86–92. doi:10.1016/j.febslet.2004.06.068. PMID   15280022. S2CID   35306314.
• Damiani MT, Pavarotti M, Leiva N, et al. (2005). "Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment". Traffic. 5 (10): 785–97. doi: 10.1111/j.1600-0854.2004.00220.x . PMID   15355514. S2CID   37310957.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Marie N, Lindsay AJ, McCaffrey MW (2005). "Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner". Biochem. J. 389 (Pt 1): 223–31. doi:10.1042/BJ20042116. PMC   1184555 . PMID   15769254.
• Tajika Y, Matsuzaki T, Suzuki T, et al. (2006). "Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments". Histochem. Cell Biol. 124 (1): 1–12. doi:10.1007/s00418-005-0010-3. PMID   16049696. S2CID   14746792.
• Patil VS, Sachdeva G, Modi DN, et al. (2006). "Rab coupling protein (RCP): a novel target of progesterone action in primate endometrium". J. Mol. Endocrinol. 35 (2): 357–72. doi: 10.1677/jme.1.01807 . PMID   16216915.
• Jin M, Goldenring JR (2006). "The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system". Biochim. Biophys. Acta. 1759 (6): 281–95. doi:10.1016/j.bbaexp.2006.06.001. PMID   16920206.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.