RAB13

RAB13
Identifiers
Aliases	RAB13 , GIG4, member RAS oncogene family
External IDs	OMIM: 602672; MGI: 1927232; HomoloGene: 113882; GeneCards: RAB13; OMA:RAB13 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.3 Start 153,981,617 bp [1] End 153,986,358 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F1|3 39.21 cM Start 90,121,002 bp [2] End 90,133,692 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium gastric mucosa Descending thoracic aorta left coronary artery right adrenal cortex left adrenal cortex fundus prostate human kidney subcutaneous adipose tissue Top expressed in yolk sac molar lens otic vesicle utricle efferent ductule external carotid artery tail of embryo epithelium of small intestine epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein kinase A catalytic subunit binding GTP binding protein binding GTPase activity Cellular component recycling endosome endosome Golgi apparatus cell projection lateral plasma membrane membrane cell-cell junction bicellular tight junction insulin-responsive compartment plasma membrane endocytic vesicle recycling endosome membrane trans-Golgi network neuron projection extracellular exosome cytoplasmic vesicle lamellipodium cytosol cell junction cytoplasmic vesicle membrane Biological process trans-Golgi network to recycling endosome transport establishment of Sertoli cell barrier protein localization to cell leading edge endosomal transport bicellular tight junction assembly endothelial cell chemotaxis endocytic recycling cellular response to insulin stimulus protein kinase A signaling protein transport neuron projection development cortical actin cytoskeleton organization post-translational protein modification transport protein localization to plasma membrane intracellular protein transport Rab protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5872 68328 Ensembl ENSG00000143545 ENSMUSG00000027935 UniProt P51153 Q9DD03 RefSeq (mRNA) NM_001272038 NM_002870 NM_001293741 NM_026677 RefSeq (protein) NP_001258967 NP_002861 NP_001280670 NP_080953 Location (UCSC) Chr 1: 153.98 – 153.99 Mb Chr 3: 90.12 – 90.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rab-13 is a protein that in humans is encoded by the RAB13 gene. ^{[5] [6]}

The RAB13 gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000143545 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027935 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zahraoui A, Joberty G, Arpin M, Fontaine JJ, Hellio R, Tavitian A, Louvard D (Feb 1994). "A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells". J Cell Biol. 124 (1–2): 101–15. doi:10.1083/jcb.124.1.101. PMC   2119893 . PMID   8294494.
6. "Entrez Gene: RAB13 RAB13, member RAS oncogene family".
7. "RAB13 RAB13, member RAS oncogene family [Homo sapiens (human)]". NCBI. 2024-10-22. Retrieved 2025-01-06.

Further reading

• Joberty G, Tavitian A, Zahraoui A (1993). "Isoprenylation of Rab proteins possessing a C-terminal CaaX motif". FEBS Lett. 330 (3): 323–8. doi: 10.1016/0014-5793(93)80897-4 . PMID   8375503. S2CID   29047580.
• Leek JP, Hamlin PJ, Wilton J, Lench NJ (1998). "Assignment of the Rab13 gene (RAB13) to human chromosome band 12q13 by in situ hybridization". Cytogenet. Cell Genet. 79 (3–4): 210–1. doi:10.1159/000134724. PMID   9605854.
• Marzesco AM, Galli T, Louvard D, Zahraoui A (1998). "The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes". J. Biol. Chem. 273 (35): 22340–5. doi: 10.1074/jbc.273.35.22340 . PMID   9712853.
• Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–62. doi:10.1055/s-2007-978953. PMID   9918381. S2CID   23540699.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Morimoto S, Nishimura N, Terai T, et al. (2005). "Rab13 mediates the continuous endocytic recycling of occludin to the cell surface". J. Biol. Chem. 280 (3): 2220–8. doi: 10.1074/jbc.M406906200 . PMID   15528189.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.