RAB1B

RAB1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JZA, 3NKV, 4HLQ, 4I1O
Identifiers
Aliases	RAB1B , member RAS oncogene family
External IDs	OMIM: 612565 MGI: 1923558 HomoloGene: 128838 GeneCards: RAB1B
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,277,492 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,157,100 bp
RNA expression pattern
	Top expressed in
	body of stomach; ; gastrocnemius muscle; ; right adrenal gland; ; right coronary artery; ; popliteal artery; ; left coronary artery; ; skin of abdomen; ; left adrenal gland; ; right lung; ; thoracic aorta;
	Top expressed in
	lip; ; yolk sac; ; superior frontal gyrus; ; spermatocyte; ; spermatid; ; epithelium of stomach; ; skeletal muscle tissue; ; ankle; ; extraocular muscle; ; right ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; GTP binding ; protein binding ; GTPase activity ;
Cellular component	cytoplasm ; phagophore assembly site membrane ; Golgi apparatus ; membrane ; Golgi membrane ; transport vesicle ; mitochondrion ; extracellular exosome ; endoplasmic reticulum-Golgi intermediate compartment membrane ; endoplasmic reticulum-Golgi intermediate compartment ; endoplasmic reticulum membrane ; cytosol ; perinuclear region of cytoplasm ;
Biological process	establishment of endothelial intestinal barrier ; positive regulation of glycoprotein metabolic process ; autophagy ; regulation of autophagosome assembly ; endoplasmic reticulum to Golgi vesicle-mediated transport ; COPII vesicle coating ; protein transport ; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ; post-translational protein modification ; transport ; intracellular protein transport ; Rab protein signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	81876
	76308
	ENSG00000174903
	ENSMUSG00000024870
	Q9H0U4
	Q9D1G1
	NM_030981
	NM_029576
	NP_112243
	NP_083852
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

Ras-related protein Rab-1B is a protein that in humans is encoded by the RAB1B gene.^[5]^[6]

Interactions

RAB1B has been shown to interact with GOLGA2.^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174903 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024870 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chen D, Guo J, Gahl WA (March 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta. 1355 (1): 1–6. doi: 10.1016/S0167-4889(96)00169-3 . PMID 9030196.
↑ "Entrez Gene: RAB1B RAB1B, member RAS oncogene family".
↑ Weide, T; Bayer M; Köster M; Siebrasse J P; Peters R; Barnekow A (April 2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. England. 2 (4): 336–41. doi:10.1093/embo-reports/kve065. ISSN 1469-221X. PMC 1083862 . PMID 11306556.

Plutner H, Cox AD, Pind S, et al. (1991). "Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments". J. Cell Biol. 115 (1): 31–43. doi:10.1083/jcb.115.1.31. PMC 2289927 . PMID 1918138.
Soldati T, Rancaño C, Geissler H, Pfeffer SR (1995). "Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processes". J. Biol. Chem. 270 (43): 25541–8. doi: 10.1074/jbc.270.43.25541 . PMID 7592724.
Wilson AL, Sheridan KM, Erdman RA, Maltese WA (1996). "Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells". Biochem. J. 318 (Pt 3): 1007–14. doi:10.1042/bj3181007. PMC 1217717 . PMID 8836150.
Overmeyer JH, Wilson AL, Erdman RA, Maltese WA (1998). "The Putative "Switch 2" Domain of the Ras-related GTPase, Rab1B, Plays an Essential Role in the Interaction with Rab Escort Protein". Mol. Biol. Cell. 9 (1): 223–35. doi:10.1091/mbc.9.1.223. PMC 25245 . PMID 9437002.
Weide T, Koster M, Barnekow A (1999). "Inactive and active mutants of rab1b are not tightly integrated into target membranes". Int. J. Oncol. 15 (4): 727–36. doi:10.3892/ijo.15.4.727. PMID 10493955.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Weide T, Bayer M, Köster M, et al. (2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. 2 (4): 336–41. doi:10.1093/embo-reports/kve065. PMC 1083862 . PMID 11306556.
Zhao H, Ettala O, Väänänen HK (2002). "Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins". Biochem. Biophys. Res. Commun. 293 (3): 1060–5. doi:10.1016/S0006-291X(02)00326-1. PMID 12051767.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
Bayer M, Fischer J, Kremerskothen J, et al. (2006). "Identification and characterization of Iporin as a novel interaction partner for rab1". BMC Cell Biol. 6 (1): 15. doi: 10.1186/1471-2121-6-15 . PMC 1079803 . PMID 15796781.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
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Monetta P, Slavin I, Romero N, Alvarez C (2007). "Rab1b Interacts with GBF1 and Modulates both ARF1 Dynamics and COPI Association". Mol. Biol. Cell. 18 (7): 2400–10. doi:10.1091/mbc.E06-11-1005. PMC 1924811 . PMID 17429068.
Machner MP, Isberg RR (2007). "A bifunctional bacterial protein links GDI displacement to Rab1 activation". Science. 318 (5852): 974–7. Bibcode:2007Sci...318..974M. doi:10.1126/science.1149121. PMID 17947549. S2CID 21889766.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000174903 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024870 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9030196-5] Chen D, Guo J, Gahl WA (March 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta. 1355 (1): 1–6. doi: 10.1016/S0167-4889(96)00169-3 . PMID 9030196.

[entrez-6] "Entrez Gene: RAB1B RAB1B, member RAS oncogene family".

[pmid11306556-7] Weide, T; Bayer M; Köster M; Siebrasse J P; Peters R; Barnekow A (April 2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. England. 2 (4): 336–41. doi:10.1093/embo-reports/kve065. ISSN 1469-221X. PMC 1083862 . PMID 11306556.

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RAB1B

Contents

Interactions

Related Research Articles

References

Further reading