RAB22A

RAB22A
Identifiers
Aliases	RAB22A , member RAS oncogene family
External IDs	OMIM: 612966; MGI: 105072; HomoloGene: 10782; GeneCards: RAB22A; OMA:RAB22A - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.32 Start 58,309,715 bp [1] End 58,367,507 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 H4|2 97.26 cM Start 173,501,553 bp [2] End 173,549,136 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus frontal pole Brodmann area 10 Brodmann area 23 Brodmann area 46 middle frontal gyrus oocyte secondary oocyte tendon of biceps brachii orbitofrontal cortex Top expressed in interventricular septum aortic valve ascending aorta cumulus cell otic vesicle right ventricle internal carotid artery temporal muscle saccule triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding GTP binding protein binding GTPase activity Cellular component endosome late endosome phagocytic vesicle membrane cell projection membrane ruffle plasma membrane early endosome phagocytic vesicle actin cytoskeleton endosome membrane extracellular exosome cytoplasmic vesicle Biological process endosome organization regulation of vesicle size protein transport transport endocytosis intracellular protein transport Rab protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57403 19334 Ensembl ENSG00000124209 ENSMUSG00000027519 UniProt Q9UL26 P35285 RefSeq (mRNA) NM_020673 NM_024436 RefSeq (protein) NP_065724 NP_077756 Location (UCSC) Chr 20: 58.31 – 58.37 Mb Chr 2: 173.5 – 173.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene. ^[5]

The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000124209 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027519 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RAB22A RAB22A, member RAS oncogene family".

Further reading

• Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–662. doi:10.1055/s-2007-978953. PMID   9918381. S2CID   23540699.
• Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni C (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–662. doi:10.1006/bbrc.1999.0651. PMID   10329441.
• Opdam FJ, Kamps G, Croes H, Van Bokhoven H, Ginsel LA, Fransen JA (2000). "Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells". Eur. J. Cell Biol. 79 (5): 308–316. doi:10.1078/S0171-9335(04)70034-5. PMID   10887961.
• Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–871. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Kauppi M, Simonsen A, Bremnes B, Vieira A, Callaghan J, Stenmark H, Olkkonen VM (2002). "The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking". J. Cell Sci. 115 (Pt 5): 899–911. doi:10.1242/jcs.115.5.899. PMID   11870209.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. 279 (6): 4670–4679. doi: 10.1074/jbc.M311228200 . PMID   14613930.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Weigert R, Yeung AC, Li J, Donaldson JG (2005). "Rab22a regulates the recycling of membrane proteins internalized independently of clathrin". Mol. Biol. Cell. 15 (8): 3758–3770. doi:10.1091/mbc.E04-04-0342. PMC   491835 . PMID   15181155.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Mesa R, Magadán J, Barbieri A, López C, Stahl PD, Mayorga LS (2005). "Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus". Exp. Cell Res. 304 (2): 339–353. doi:10.1016/j.yexcr.2004.11.017. PMID   15748882.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–1625. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Magadán JG, Barbieri MA, Mesa R, Stahl PD, Mayorga LS (2006). "Rab22a regulates the sorting of transferrin to recycling endosomes". Mol. Cell. Biol. 26 (7): 2595–2614. doi:10.1128/MCB.26.7.2595-2614.2006. PMC   1430328 . PMID   16537905.