RAB25

RAB25
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OIL, 3TSO
Identifiers
Aliases	RAB25 , CATX-8, RAB11C, member RAS oncogene family
External IDs	OMIM: 612942 MGI: 1858203 HomoloGene: 22995 GeneCards: RAB25
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q22 Start 156,061,160 bp [1] End 156,070,504 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F1 Start 88,449,336 bp [2] End 88,455,607 bp [2]
RNA expression pattern Bgee Top expressed in esophagus gums vagina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding myosin V binding GO:0001948 protein binding GO:0006184 GTPase activity Cellular component pseudopodium membrane plasma membrane cell projection pseudopodium extracellular exosome GO:0016023 cytoplasmic vesicle membrane endosome recycling endosome Biological process protein transport regulation of vesicle-mediated transport positive regulation of epithelial cell migration epithelial cell morphogenesis positive regulation of cell population proliferation pseudopodium organization transport intracellular protein transport exocytosis Rab protein signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57111	53868
Ensembl	ENSG00000132698	ENSMUSG00000008601
UniProt	P57735	Q9WTL2
RefSeq (mRNA)	NM_020387	NM_016899
RefSeq (protein)	NP_065120	NP_058595
Location (UCSC)	Chr 1: 156.06 – 156.07 Mb	Chr 3: 88.45 – 88.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene. ^{[5] [6]} It is thought to act as a promoter of tumor development. ^[7]

Interactions

RAB25 has been shown to interact with RAB11FIP2 ^{[8] [9]} and RAB11FIP5. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000132698 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008601 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pereira-Leal JB, Seabra MC (November 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID   11697911.
6. "Entrez Gene: RAB25 RAB25, member RAS oncogene family".
7. Kessler, D; Gruen, GC; Heider, D; Morgner, J; Reis, H; Schmid, KW; Jendrossek, V (2012). "The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration". Cellular Physiology and Biochemistry. 29 (5–6): 647–56. doi: 10.1159/000295249 . PMID   22613965.
8. Hales, C M; Griner R; Hobdy-Henderson K C; Dorn M C; Hardy D; Kumar R; Navarre J; Chan E K; Lapierre L A; Goldenring J R (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi: 10.1074/jbc.M104831200 . ISSN   0021-9258. PMID   11495908.
9. Prekeris, R; Davies J M; Scheller R H (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. 276 (42): 38966–70. doi: 10.1074/jbc.M106133200 . ISSN   0021-9258. PMID   11481332.

Further reading

• Goldenring JR, Shen KR, Vaughan HD, Modlin IM (1993). "Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung". J. Biol. Chem. 268 (25): 18419–22. doi: 10.1016/S0021-9258(17)46639-7 . PMID   8360141.
• Ray GS, Lee JR, Nwokeji K, et al. (1997). "Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia". Lab. Invest. 77 (5): 503–11. PMID   9389793.
• Lapierre LA, Kumar R, Hales CM, et al. (2001). "Myosin vb is associated with plasma membrane recycling systems". Mol. Biol. Cell. 12 (6): 1843–57. doi:10.1091/mbc.12.6.1843. PMC   37346 . PMID   11408590.
• Prekeris R, Davies JM, Scheller RH (2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. 276 (42): 38966–70. doi: 10.1074/jbc.M106133200 . PMID   11481332.
• Hales CM, Griner R, Hobdy-Henderson KC, et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi: 10.1074/jbc.M104831200 . PMID   11495908.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC   311163 . PMID   11591653.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Fan Y, Xin XY, Chen BL, Ma X (2007). "Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo". Pathology. 38 (6): 561–7. doi:10.1080/00313020601024037. PMID   17393986. S2CID   85960469.