RAB25

RAB25
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OIL, 3TSO
Identifiers
Aliases	RAB25 , CATX-8, RAB11C, member RAS oncogene family
External IDs	OMIM: 612942; MGI: 1858203; HomoloGene: 22995; GeneCards: RAB25; OMA:RAB25 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q22 Start 156,061,160 bp [1] End 156,070,504 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F1 Start 88,449,336 bp [2] End 88,455,607 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon skin of abdomen skin of leg gums mucosa of pharynx gingival epithelium skin of thigh oral cavity rectum human penis Top expressed in transitional epithelium of urinary bladder lip esophagus epithelium of stomach left colon skin of external ear mucous cell of stomach cervix pyloric antrum duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding myosin V binding protein binding GTPase activity Cellular component pseudopodium membrane plasma membrane cell projection pseudopodium extracellular exosome cytoplasmic vesicle membrane endosome recycling endosome Biological process protein transport regulation of vesicle-mediated transport positive regulation of epithelial cell migration epithelial cell morphogenesis positive regulation of cell population proliferation pseudopodium organization transport intracellular protein transport exocytosis Rab protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57111 53868 Ensembl ENSG00000132698 ENSMUSG00000008601 UniProt P57735 Q9WTL2 RefSeq (mRNA) NM_020387 NM_016899 RefSeq (protein) NP_065120 NP_058595 Location (UCSC) Chr 1: 156.06 – 156.07 Mb Chr 3: 88.45 – 88.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene. ^{[5] [6]} It is thought to act as a promoter of tumor development. ^[7]

Interactions

RAB25 has been shown to interact with RAB11FIP2 ^{[8] [9]} and RAB11FIP5. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000132698 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008601 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pereira-Leal JB, Seabra MC (November 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID   11697911.
6. "Entrez Gene: RAB25 RAB25, member RAS oncogene family".
7. Kessler, D; Gruen, GC; Heider, D; Morgner, J; Reis, H; Schmid, KW; Jendrossek, V (2012). "The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration". Cellular Physiology and Biochemistry. 29 (5–6): 647–56. doi: 10.1159/000295249 . PMID   22613965.
8. Hales, C M; Griner R; Hobdy-Henderson K C; Dorn M C; Hardy D; Kumar R; Navarre J; Chan E K; Lapierre L A; Goldenring J R (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi: 10.1074/jbc.M104831200 . ISSN   0021-9258. PMID   11495908.
9. Prekeris, R; Davies J M; Scheller R H (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. 276 (42): 38966–70. doi: 10.1074/jbc.M106133200 . ISSN   0021-9258. PMID   11481332.

Further reading

• Goldenring JR, Shen KR, Vaughan HD, Modlin IM (1993). "Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung". J. Biol. Chem. 268 (25): 18419–22. doi: 10.1016/S0021-9258(17)46639-7 . PMID   8360141.
• Ray GS, Lee JR, Nwokeji K, et al. (1997). "Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia". Lab. Invest. 77 (5): 503–11. PMID   9389793.
• Lapierre LA, Kumar R, Hales CM, et al. (2001). "Myosin vb is associated with plasma membrane recycling systems". Mol. Biol. Cell. 12 (6): 1843–57. doi:10.1091/mbc.12.6.1843. PMC   37346 . PMID   11408590.
• Prekeris R, Davies JM, Scheller RH (2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. 276 (42): 38966–70. doi: 10.1074/jbc.M106133200 . PMID   11481332.
• Hales CM, Griner R, Hobdy-Henderson KC, et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi: 10.1074/jbc.M104831200 . PMID   11495908.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC   311163 . PMID   11591653.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Fan Y, Xin XY, Chen BL, Ma X (2007). "Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo". Pathology. 38 (6): 561–7. doi:10.1080/00313020601024037. PMID   17393986. S2CID   85960469.