RAB38

RAB38
Identifiers
Aliases	RAB38 , NY-MEL-1, rrGTPbp, member RAS oncogene family
External IDs	OMIM: 606281 MGI: 1919683 HomoloGene: 21353 GeneCards: RAB38
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q14.2 Start 88,113,251 bp [1] End 88,175,443 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 D3|7 49.19 cM Start 88,079,481 bp [2] End 88,140,780 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva vulva human penis skin of abdomen hair follicle germinal epithelium cavity of mouth retinal pigment epithelium Left adrenal gland vagina Top expressed in secondary oocyte molar iris epidermis hair follicle skin of abdomen cornea wall of esophagus nasolacrimal duct lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function AP-2 adaptor complex binding nucleotide binding BLOC-2 complex binding GTP binding GTP-dependent protein binding protein binding AP-3 adaptor complex binding AP-1 adaptor complex binding GTPase activity Cellular component cytoplasm vesicle phagocytic vesicle membrane Golgi apparatus membrane melanosome plasma membrane early endosome phagocytic vesicle endoplasmic reticulum early endosome lumen cytoplasmic vesicle lysosome mitochondrion mitochondria-associated endoplasmic reticulum membrane cytosol melanosome membrane trans-Golgi network Biological process protein localization to membrane platelet dense granule organization organelle organization phagosome acidification endosome to melanosome transport protein transport melanosome assembly mitochondrion organization vesicle-mediated transport small GTPase mediated signal transduction post-translational protein modification positive regulation of phosphatidylcholine biosynthetic process intracellular protein transport Rab protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23682 72433 Ensembl ENSG00000123892 ENSMUSG00000030559 UniProt P57729 Q8QZZ8 RefSeq (mRNA) NM_022337 NM_028238 RefSeq (protein) NP_071732 NP_071732.1 NP_082514 Location (UCSC) Chr 11: 88.11 – 88.18 Mb Chr 7: 88.08 – 88.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rab-38 is a protein that in humans is encoded by the RAB38 gene. ^{[5] [6]}

In melanocytic cells RAB38 gene expression may be regulated by MITF. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000123892 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030559 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res. 60 (13): 3584–91. PMID   10910072.
6. "Entrez Gene: RAB38 RAB38, member RAS oncogene family".
7. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID   19067971. S2CID   24698373.

Further reading

• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID   17081065.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Suzuki T, Miyamura Y, Inagaki K, Tomita Y (2004). "Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA". J. Dermatol. Sci. 32 (2): 131–6. doi:10.1016/S0923-1811(03)00071-9. PMID   12850305.
• Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID   12643545.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Osanai K, Iguchi M, Takahashi K, et al. (2001). "Expression and Localization of a Novel Rab Small G Protein (Rab38) in the Rat Lung". Am. J. Pathol. 158 (5): 1665–75. doi:10.1016/S0002-9440(10)64122-3. PMC   1891947 . PMID   11337364.