RAB3B

RAB3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DZ8
Identifiers
Aliases	RAB3B , member RAS oncogene family
External IDs	OMIM: 179510 MGI: 1917158 HomoloGene: 2149 GeneCards: RAB3B
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p32.3 Start 51,907,956 bp [1] End 51,990,700 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 C7 Start 108,736,260 bp [2] End 108,800,521 bp [2]
RNA expression pattern Bgee Top expressed in islet of Langerhans pituitary gland dorsolateral prefrontal cortex anterior pituitary caudate nucleus hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding GTP binding myosin V binding GO:0001948 protein binding GTP-dependent protein binding GO:0006184 GTPase activity Cellular component cytoplasm vesicle cytosol membrane synaptic vesicle plasma membrane secretory granule perinuclear region of cytoplasm extracellular exosome anchored component of synaptic vesicle membrane endosome Golgi apparatus dopaminergic synapse Biological process antigen processing and presentation positive regulation of dopamine uptake involved in synaptic transmission peptidyl-cysteine methylation regulation of exocytosis regulation of vesicle size protein transport transport intracellular protein transport vesicle docking involved in exocytosis protein secretion Rab protein signal transduction protein localization to plasma membrane regulation of synaptic vesicle cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5865	69908
Ensembl	ENSG00000169213	ENSMUSG00000003411
UniProt	P20337	Q9CZT8
RefSeq (mRNA)	NM_002867	NM_023537
RefSeq (protein)	NP_002858	NP_076026
Location (UCSC)	Chr 1: 51.91 – 51.99 Mb	Chr 4: 108.74 – 108.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rab-3B is a protein that in humans is encoded by the RAB3B gene. ^[5]

Interactions

RAB3B has been shown to interact with RPH3A. ^{[6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000169213 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003411 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RAB3B RAB3B, member RAS oncogene family".
6. Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi: 10.1074/jbc.M212341200 . PMID   12578829.
7. Weber E, Jilling T, Kirk KL (March 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". The Journal of Biological Chemistry. 271 (12): 6963–71. doi: 10.1074/jbc.271.12.6963 . PMID   8636125.

Further reading

• Rousseau-Merck MF, Zahraoui A, Touchot N, Tavitian A, Berger R (February 1991). "Chromosome assignment of four RAS-related RAB genes". Human Genetics. 86 (4): 350–4. doi:10.1007/BF00201831. PMID   1999336. S2CID   30730416.
• Zahraoui A, Touchot N, Chardin P, Tavitian A (July 1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion". The Journal of Biological Chemistry. 264 (21): 12394–401. doi: 10.1016/S0021-9258(18)63872-4 . PMID   2501306.
• Weber E, Berta G, Tousson A, St John P, Green MW, Gopalokrishnan U, Jilling T, Sorscher EJ, Elton TS, Abrahamson DR (May 1994). "Expression and polarized targeting of a rab3 isoform in epithelial cells". The Journal of Cell Biology. 125 (3): 583–94. doi:10.1083/jcb.125.3.583. PMC   2119989 . PMID   8175882.
• Weber E, Jilling T, Kirk KL (March 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". The Journal of Biological Chemistry. 271 (12): 6963–71. doi: 10.1074/jbc.271.12.6963 . PMID   8636125.
• Regazzi R, Ravazzola M, Iezzi M, Lang J, Zahraoui A, Andereggen E, Morel P, Takai Y, Wollheim CB (September 1996). "Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells". Journal of Cell Science. 109 ( Pt 9) (9): 2265–73. doi:10.1242/jcs.109.9.2265. PMID   8886977.
• Sidhu RS, Bhullar RP (December 2001). "Rab3B in human platelet is membrane bound and interacts with Ca(2+)/calmodulin". Biochemical and Biophysical Research Communications. 289 (5): 1039–43. doi:10.1006/bbrc.2001.6113. PMID   11741295.
• van IJzendoorn SC, Tuvim MJ, Weimbs T, Dickey BF, Mostov KE (February 2002). "Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells". Developmental Cell. 2 (2): 219–28. doi: 10.1016/S1534-5807(02)00115-6 . PMID   11832247.
• Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi: 10.1074/jbc.M212341200 . PMID   12578829.
• Yamamoto Y, Nishimura N, Morimoto S, Kitamura H, Manabe S, Kanayama HO, Kagawa S, Sasaki T (August 2003). "Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane". Biochemical and Biophysical Research Communications. 308 (2): 270–5. doi:10.1016/S0006-291X(03)01358-5. PMID   12901864.
• Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S (June 2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (22): 8313–8. Bibcode:2004PNAS..101.8313M. doi: 10.1073/pnas.0306709101 . PMC   420391 . PMID   15159548.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.