RAB5B

RAB5B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HEI
Identifiers
Aliases	RAB5B , Rab-5B, member RAS oncogene family
External IDs	OMIM: 179514 MGI: 105938 HomoloGene: 104027 GeneCards: RAB5B
Gene location (Human)
Chr.	Chromosome 12 (human)
End	55,996,683 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,532,133 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; skin of abdomen; ; gastric mucosa; ; right coronary artery; ; canal of the cervix; ; rectum; ; right lung; ; nucleus accumbens; ; amygdala; ; transverse colon;
	Top expressed in
	lip; ; superior frontal gyrus; ; esophagus; ; cerebellar cortex; ; yolk sac; ; stomach; ; spermatocyte; ; thymus; ; hand; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; GDP binding ; GTP binding ; GTP-dependent protein binding ; protein binding ; GTPase activity ;
Cellular component	endosome ; membrane ; melanosome ; endocytic vesicle ; intracellular anatomical structure ; early endosome ; extracellular exosome ; plasma membrane ; secretory granule membrane ; early endosome membrane ; intracellular membrane-bounded organelle ; anchored component of synaptic vesicle membrane ;
Biological process	regulation of endocytosis ; antigen processing and presentation ; endosome organization ; plasma membrane to endosome transport ; protein transport ; neutrophil degranulation ; transport ; intracellular protein transport ; Rab protein signal transduction ; endocytosis ;
	Sources:Amigo / QuickGO
Orthologs
	5869
	19344
	ENSG00000111540
	ENSMUSG00000000711
	P61020
	P61021
	NM_001252036 ; NM_001252037 ; NM_002868
	NM_011229 ; NM_177411
	NP_001238965 ; NP_001238966 ; NP_002859
	NP_803130
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 29, 2023

Ras-related protein Rab-5B is a protein that in humans is encoded by the RAB5B gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111540 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000711 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wilson DB, Wilson MP (Apr 1992). "Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases". J Clin Invest. 89 (3): 996–1005. doi:10.1172/JCI115683. PMC 442949 . PMID 1541686.
↑ Chiariello M, Bruni CB, Bucci C (Aug 1999). "The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro". FEBS Lett. 453 (1–2): 20–4. doi:10.1016/S0014-5793(99)00686-9. PMID 10403367. S2CID 30308802.
↑ "Entrez Gene: RAB5B RAB5B, member RAS oncogene family".

Bucci C, Lütcke A, Steele-Mortimer O, Olkkonen VM, Dupree P, Chiariello M, Bruni CB, Simons K, Zerial M (1995). "Co-operative regulation of endocytosis by three Rab5 isoforms". FEBS Lett. 366 (1): 65–71. doi: 10.1016/0014-5793(95)00477-Q . PMID 7789520. S2CID 40284549.
Korenberg JR, Chen XN, Adams MD, Venter JC (1996). "Toward a cDNA map of the human genome". Genomics. 29 (2): 364–70. doi:10.1006/geno.1995.9993. PMID 8666383.
Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–62. doi:10.1055/s-2007-978953. PMID 9918381. S2CID 23540699.
Callaghan J, Nixon S, Bucci C, Toh BH, Stenmark H (1999). "Direct interaction of EEA1 with Rab5b". Eur. J. Biochem. 265 (1): 361–6. doi: 10.1046/j.1432-1327.1999.00743.x . PMID 10491193.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF (2001). "Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1". Dev. Cell. 1 (1): 73–82. doi: 10.1016/S1534-5807(01)00008-9 . PMID 11703925.
Saito K, Murai J, Kajiho H, Kontani K, Kurosu H, Katada T (2002). "A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5". J. Biol. Chem. 277 (5): 3412–8. doi: 10.1074/jbc.M106276200 . PMID 11733506.
Merithew E, Stone C, Eathiraj S, Lambright DG (2003). "Determinants of Rab5 interaction with the N terminus of early endosome antigen 1". J. Biol. Chem. 278 (10): 8494–500. doi: 10.1074/jbc.M211514200 . PMID 12493736.
Kajiho H, Saito K, Tsujita K, Kontani K, Araki Y, Kurosu H, Katada T (2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway". J. Cell Sci. 116 (Pt 20): 4159–68. doi: 10.1242/jcs.00718 . PMID 12972505.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
Hirota Y, Kuronita T, Fujita H, Tanaka Y (2007). "A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartments". Biochem. Biophys. Res. Commun. 364 (1): 40–7. doi:10.1016/j.bbrc.2007.09.089. PMID 17927960.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000111540 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000711 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1541686-5] Wilson DB, Wilson MP (Apr 1992). "Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases". J Clin Invest. 89 (3): 996–1005. doi:10.1172/JCI115683. PMC 442949 . PMID 1541686.

[pmid10403367-6] Chiariello M, Bruni CB, Bucci C (Aug 1999). "The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro". FEBS Lett. 453 (1–2): 20–4. doi:10.1016/S0014-5793(99)00686-9. PMID 10403367. S2CID 30308802.

[entrez-7] "Entrez Gene: RAB5B RAB5B, member RAS oncogene family".

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RAB5B

Related Research Articles

References

Further reading