RAB5C

RAB5C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KYI
Identifiers
Aliases	RAB5C , L1880, RAB5CL, RAB5L, RABL, member RAS oncogene family
External IDs	OMIM: 604037; MGI: 105306; HomoloGene: 55533; GeneCards: RAB5C; OMA:RAB5C - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.2 Start 42,124,978 bp [1] End 42,155,044 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 D|11 63.54 cM Start 100,605,835 bp [2] End 100,629,041 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte right lung upper lobe of left lung right adrenal cortex body of stomach left adrenal gland gallbladder right coronary artery right lobe of thyroid gland Top expressed in yolk sac granulocyte lip intestinal villus dentate gyrus of hippocampal formation granule cell Ileal epithelium superior frontal gyrus gastrula stroma of bone marrow primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding GDP binding GTPase activity Cellular component melanosome lysosomal membrane endosome lipid droplet endocytic vesicle early endosome extracellular exosome membrane plasma membrane early endosome membrane azurophil granule membrane cytoplasmic vesicle anchored component of synaptic vesicle membrane intracellular anatomical structure Biological process protein transport regulation of endocytosis plasma membrane to endosome transport neutrophil degranulation transport intracellular protein transport Rab protein signal transduction small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5878 19345 Ensembl ENSG00000108774 ENSMUSG00000019173 UniProt P51148 P35278 RefSeq (mRNA) NM_001252039 NM_004583 NM_201434 NM_024456 NM_001305003 RefSeq (protein) NP_001238968 NP_004574 NP_958842 NP_001291932 NP_077776 Location (UCSC) Chr 17: 42.12 – 42.16 Mb Chr 11: 100.61 – 100.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rab-5C is a protein that in humans is encoded by the RAB5C gene. ^{[5] [6]} RAB5C belongs to the Ras-related protein family.

References

1. GRCh38: Ensembl release 89: ENSG00000108774 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019173 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Han HJ, Sudo K, Inazawa J, Nakamura Y (Jul 1996). "Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene". Cytogenet Cell Genet. 73 (1–2): 137–9. doi:10.1159/000134325. PMID   8646882.
6. "Entrez Gene: RAB5C RAB5C, member RAS oncogene family".

Further reading

• Albertsen HM, Smith SA, Mazoyer S, et al. (1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21". Nat. Genet. 7 (4): 472–9. doi:10.1038/ng0894-472. PMID   7951316. S2CID   11075629.
• Alvarez-Dominguez C, Stahl PD (1999). "Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells". J. Biol. Chem. 273 (51): 33901–4. doi: 10.1074/jbc.273.51.33901 . PMID   9852039.
• Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID   10329441.
• Clemens DL, Lee BY, Horwitz MA (2000). "Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate". Infect. Immun. 68 (5): 2671–84. doi:10.1128/IAI.68.5.2671-2684.2000. PMC   97474 . PMID   10768959.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Merithew E, Stone C, Eathiraj S, Lambright DG (2003). "Determinants of Rab5 interaction with the N terminus of early endosome antigen 1". J. Biol. Chem. 278 (10): 8494–500. doi: 10.1074/jbc.M211514200 . PMID   12493736.
• Kajiho H, Saito K, Tsujita K, et al. (2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway". J. Cell Sci. 116 (Pt 20): 4159–68. doi:10.1242/jcs.00718. PMID   12972505. S2CID   18217293.
• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID   17081065.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.