RAB7B

RAB7B
Identifiers
Aliases	RAB7B , RAB7, member RAS oncogene family
External IDs	MGI: 2442295 HomoloGene: 64833 GeneCards: RAB7B
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 205,976,740 bp [1] End 206,003,461 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 131,616,433 bp [2] End 131,643,177 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen gallbladder right coronary artery vagina vulva smooth muscle tissue human penis parietal pleura left uterine tube left lobe of thyroid gland Top expressed in lip skin of back calvaria epidermis esophagus skin of abdomen belly cord cornea ankle hair follicle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding GTPase activity Cellular component endosome late endosome Golgi apparatus trans-Golgi network lysosome phagocytic vesicle membrane phagocytic vesicle membrane cytoplasmic vesicle late endosome membrane vacuolar membrane Biological process protein transport negative regulation of toll-like receptor 9 signaling pathway late endosome to Golgi transport positive regulation of NF-kappaB transcription factor activity positive regulation of megakaryocyte differentiation negative regulation of toll-like receptor 4 signaling pathway positive regulation of interleukin-6 production cellular response to interferon-gamma intracellular protein transport endosome to lysosome transport Rab protein signal transduction phagosome-lysosome fusion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338382 226421 Ensembl ENSG00000276600 ENSMUSG00000052688 UniProt Q96AH8 Q8VEA8 RefSeq (mRNA) NM_001164522 NM_001304839 NM_177403 NM_145509 NM_001311096 RefSeq (protein) NP_001157994 NP_001291768 NP_796377 NP_001298025 NP_663484 Location (UCSC) Chr 1: 205.98 – 206 Mb Chr 1: 131.62 – 131.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene. ^[5]

Function

Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells. ^[6] By promoting the degradation of toll-like receptor 4, RAB7B can negatively regulate the inflammatory activation of macrophages. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000276600 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052688 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yang M, Chen T, Han C, Li N, Wan T, Cao X (June 2004). "Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells". Biochem. Biophys. Res. Commun. 318 (3): 792–9. doi:10.1016/j.bbrc.2004.04.115. PMID   15144907.
6. Wang Y, Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X (August 2007). "Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4". Blood. 110 (3): 962–71. doi: 10.1182/blood-2007-01-066027 . PMID   17395780. S2CID   28664736.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.