RABGAP1

RABGAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NC6
Identifiers
Aliases	RABGAP1 , GAPCENA, TBC1D11, RAB GTPase activating protein 1
External IDs	OMIM: 615882 MGI: 2385139 HomoloGene: 49301 GeneCards: RABGAP1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	123,104,866 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	37,456,466 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; middle temporal gyrus; ; olfactory bulb; ; internal globus pallidus; ; optic nerve; ; amniotic fluid; ; endothelial cell; ; Brodmann area 23; ; saphenous vein; ; palpebral conjunctiva;
	Top expressed in
	pineal gland; ; superior cervical ganglion; ; arcuate nucleus; ; paraventricular nucleus of hypothalamus; ; median eminence; ; dorsomedial hypothalamic nucleus; ; medullary collecting duct; ; ventral tegmental area; ; mammillary body; ; lateral hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	tubulin binding ; protein binding ; GTPase activator activity ;
Cellular component	cytoplasm ; cytosol ; centrosome ; cytoskeleton ; microtubule associated complex ; microtubule organizing center ; endomembrane system ;
Biological process	regulation of cilium assembly ; cell cycle ; positive regulation of GTPase activity ; activation of GTPase activity ; regulation of vesicle fusion ; intracellular protein transport ; regulation of GTPase activity ;
	Sources:Amigo / QuickGO
Orthologs
	23637
	227800
	ENSG00000011454
	ENSMUSG00000035437
	Q9Y3P9
	A2AWA9
	NM_012197
	NM_001033960 ; NM_146121 ; NM_001362956 ; NM_001362957 ; NM_001362958
	NP_036329
	NP_001029132 ; NP_666233 ; NP_001349885 ; NP_001349886 ; NP_001349887
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

RAB GTPase activating protein 1 is a protein in humans that is encoded by the RABGAP1 gene.^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000011454 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035437 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: RAB GTPase activating protein 1".

Caratù G, Allegra D, Bimonte M, Schiattarella GG, D'Ambrosio C, Scaloni A, Napolitano M, Russo T, Zambrano N (February 2007). "Identification of the ligands of protein interaction domains through a functional approach". Molecular & Cellular Proteomics. 6 (2): 333–45. doi: 10.1074/mcp.M600289-MCP200 . PMID 17124247.
Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Molecular Biology of the Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039 . PMID 11071909.
Ishibashi K, Kanno E, Itoh T, Fukuda M (January 2009). "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity". Genes to Cells. 14 (1): 41–52. doi: 10.1111/j.1365-2443.2008.01251.x . PMID 19077034. S2CID 26454981.
Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (August 2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus". Journal of Cell Science. 113 ( Pt 15) (15): 2725–35. doi:10.1242/jcs.113.15.2725. PMID 10893188.
Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B (April 1999). "Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome". The EMBO Journal. 18 (7): 1772–82. doi:10.1093/emboj/18.7.1772. PMC 1171263 . PMID 10202141.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000011454 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035437 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RAB GTPase activating protein 1".

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RABGAP1

Related Research Articles

References

Further reading