RABGAP1

RABGAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NC6
Identifiers
Aliases	RABGAP1 , GAPCENA, TBC1D11, RAB GTPase activating protein 1
External IDs	OMIM: 615882; MGI: 2385139; HomoloGene: 49301; GeneCards: RABGAP1; OMA:RABGAP1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q33.2-q33.3 Start 122,940,833 bp [1] End 123,104,866 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 B Start 37,333,291 bp [2] End 37,456,466 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte middle temporal gyrus olfactory bulb internal globus pallidus optic nerve amniotic fluid endothelial cell tail of epididymis Brodmann area 23 saphenous vein Top expressed in genital tubercle tail of embryo pineal gland zygote superior cervical ganglion arcuate nucleus paraventricular nucleus of hypothalamus median eminence dorsomedial hypothalamic nucleus medullary collecting duct More reference expression data BioGPS n/a
Gene ontology Molecular function tubulin binding protein binding GTPase activator activity Cellular component cytoplasm cytosol centrosome cytoskeleton microtubule associated complex microtubule organizing center endomembrane system Biological process regulation of cilium assembly cell cycle positive regulation of GTPase activity activation of GTPase activity regulation of vesicle fusion intracellular protein transport regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23637 227800 Ensembl ENSG00000011454 ENSMUSG00000035437 UniProt Q9Y3P9 A2AWA9 RefSeq (mRNA) NM_012197 NM_001033960 NM_146121 NM_001362956 NM_001362957 NM_001362958 RefSeq (protein) NP_036329 NP_001029132 NP_666233 NP_001349885 NP_001349886 NP_001349887 Location (UCSC) Chr 9: 122.94 – 123.1 Mb Chr 2: 37.33 – 37.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RAB GTPase activating protein 1 is a protein in humans that is encoded by the RABGAP1 gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000011454 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035437 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RAB GTPase activating protein 1".

Further reading

• Caratù G, Allegra D, Bimonte M, Schiattarella GG, D'Ambrosio C, Scaloni A, Napolitano M, Russo T, Zambrano N (February 2007). "Identification of the ligands of protein interaction domains through a functional approach". Molecular & Cellular Proteomics. 6 (2): 333–45. doi: 10.1074/mcp.M600289-MCP200 . PMID   17124247.
• Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Molecular Biology of the Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC   15039 . PMID   11071909.
• Ishibashi K, Kanno E, Itoh T, Fukuda M (January 2009). "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity". Genes to Cells. 14 (1): 41–52. doi: 10.1111/j.1365-2443.2008.01251.x . PMID   19077034. S2CID   26454981.
• Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (August 2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus". Journal of Cell Science. 113 ( Pt 15) (15): 2725–35. doi:10.1242/jcs.113.15.2725. PMID   10893188.
• Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B (April 1999). "Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome". The EMBO Journal. 18 (7): 1772–82. doi:10.1093/emboj/18.7.1772. PMC   1171263 . PMID   10202141.