RAGE (gene)

MOK
Identifiers
Aliases	MOK , RAGE, RAGE-1, RAGE1, STK30, MOK protein kinase
External IDs	OMIM: 605762; MGI: 1336881; HomoloGene: 8062; GeneCards: MOK; OMA:MOK - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.31 Start 102,224,500 bp [1] End 102,305,190 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 F1 Start 110,807,798 bp [2] End 110,840,939 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left testis right testis epithelium of bronchus anterior pituitary bronchial epithelial cell sural nerve right lobe of thyroid gland olfactory zone of nasal mucosa left lobe of thyroid gland Top expressed in superior surface of tongue gallbladder seminiferous tubule zygote spermatid spermatocyte secondary oocyte primary oocyte neural layer of retina saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ATP binding kinase activity metal ion binding Cellular component cell projection cilium ciliary base nucleus cytoplasm Biological process protein phosphorylation phosphorylation signal transduction regulation of cell cycle regulation of gene expression intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5891 26448 Ensembl ENSG00000080823 ENSMUSG00000056458 UniProt Q9UQ07 Q9WVS4 RefSeq (mRNA) NM_001272011 NM_014226 NM_001330234 NM_001353827 NM_001353828 NM_001353829 NM_001353830 NM_001353831 NM_001353832 NM_011973 RefSeq (protein) NP_001258940 NP_001317163 NP_055041 NP_001340756 NP_001340757 NP_001340758 NP_001340759 NP_001340760 NP_001340761 NP_036103 Location (UCSC) Chr 14: 102.22 – 102.31 Mb Chr 12: 110.81 – 110.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MAPK/MAK/MRK overlapping kinase is an enzyme that in humans is encoded by the RAGE gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000080823 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056458 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gaugler B, Brouwenstijn N, Vantomme V, Szikora JP, Van der Spek CW, Patard JJ, Boon T, Schrier P, Van den Eynde BJ (Oct 1996). "A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma". Immunogenetics. 44 (5): 323–30. doi:10.1007/BF02602776. PMID   8781117. S2CID   20056364.
6. Miyata Y, Akashi M, Nishida E (May 1999). "Molecular cloning and characterization of a novel member of the MAP kinase superfamily". Genes to Cells. 4 (5): 299–309. doi: 10.1046/j.1365-2443.1999.00261.x . PMID   10421840.
7. "Entrez Gene: RAGE renal tumor antigen".

Further reading

• Eichmüller S, Usener D, Jochim A, Schadendorf D (August 2002). "mRNA expression of tumor-associated antigens in melanoma tissues and cell lines". Experimental Dermatology. 11 (4): 292–301. doi:10.1034/j.1600-0625.2002.110402.x. PMID   12190937. S2CID   22559064.
• Götte K, Usener D, Riedel F, Hörmann K, Schadendorf D, Eichmüller S (July 2002). "Tumor-associated antigens as possible targets for immune therapy in head and neck cancer: comparative mRNA expression analysis of RAGE and GAGE genes". Acta Oto-Laryngologica. 122 (5): 546–52. doi:10.1080/00016480260092381. PMID   12206267. S2CID   7087339.
• Yan M, Ghorab Z, Nadji M (June 2003). "Renal cell carcinoma antigen is expressed by yolk sac tumors and yolk sac elements of embryonal carcinomas". Applied Immunohistochemistry & Molecular Morphology. 11 (2): 113–5. doi:10.1097/00129039-200306000-00003. PMID   12777992. S2CID   29045611.
• Miura J, Uchigata Y, Yamamoto Y, Takeuchi M, Sakurai S, Watanabe T, Yonekura H, Yamagishi S, Makita Z, Sato A, Omori Y, Yamamoto H, Iwamoto Y (2004). "AGE down-regulation of monocyte RAGE expression and its association with diabetic complications in type 1 diabetes". Journal of Diabetes and Its Complications. 18 (1): 53–9. doi:10.1016/S1056-8727(02)00281-7. PMID   15019601.
• Rudofsky G, Isermann B, Schilling T, Schiekofer S, Andrassy M, Schneider JG, Morcos M, Humpert PM, Sayed AA, Witte S, Renn W, Pfohl M, Hamann A, Nosikov V, Schleicher E, Häring HU, Rudofsky G, Ritz E, Nawroth PP, Bierhaus A (March 2004). "A 63bp deletion in the promoter of rage correlates with a decreased risk for nephropathy in patients with type 2 diabetes". Experimental and Clinical Endocrinology & Diabetes. 112 (3): 135–41. doi:10.1055/s-2004-817822. PMID   15052533. S2CID   260134909.
• Uesaka T, Kageyama N (August 2004). "Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells". FEBS Letters. 573 (1–3): 147–54. doi:10.1016/j.febslet.2004.07.070. PMID   15327990. S2CID   42372904.
• Bierhaus A, Haslbeck KM, Humpert PM, Liliensiek B, Dehmer T, Morcos M, Sayed AA, Andrassy M, Schiekofer S, Schneider JG, Schulz JB, Heuss D, Neundörfer B, Dierl S, Huber J, Tritschler H, Schmidt AM, Schwaninger M, Haering HU, Schleicher E, Kasper M, Stern DM, Arnold B, Nawroth PP (December 2004). "Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily". The Journal of Clinical Investigation. 114 (12): 1741–51. doi:10.1172/JCI18058. PMC   535062 . PMID   15599399.
• Grunau C, Sanchez C, Ehrlich M, van der Bruggen P, Hindermann W, Rodriguez C, Krieger S, Dubeau L, Fiala E, De Sario A (May 2005). "Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer". Genes, Chromosomes & Cancer. 43 (1): 11–24. doi:10.1002/gcc.20155. PMID   15704127. S2CID   38956616.
• dos Santos KG, Canani LH, Gross JL, Tschiedel B, Pires Souto KE, Roisenberg I (June 2005). "The -374A allele of the receptor for advanced glycation end products gene is associated with a decreased risk of ischemic heart disease in African-Brazilians with type 2 diabetes". Molecular Genetics and Metabolism. 85 (2): 149–56. doi:10.1016/j.ymgme.2005.02.010. PMID   15896660.
• Oehlrich N, Devitt G, Linnebacher M, Schwitalle Y, Grosskinski S, Stevanovic S, Zöller M (November 2005). "Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell carcinoma". International Journal of Cancer. 117 (2): 256–64. doi: 10.1002/ijc.21200 . PMID   15900605.
• Dumitriu IE, Baruah P, Bianchi ME, Manfredi AA, Rovere-Querini P (July 2005). "Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells". European Journal of Immunology. 35 (7): 2184–90. doi: 10.1002/eji.200526066 . PMID   15915542.
• Haslbeck KM, Friess U, Schleicher ED, Bierhaus A, Nawroth PP, Kirchner A, Pauli E, Neundörfer B, Heuss D (September 2005). "The RAGE pathway in inflammatory myopathies and limb girdle muscular dystrophy". Acta Neuropathologica. 110 (3): 247–54. doi:10.1007/s00401-005-1043-3. PMID   15986224. S2CID   19040474.
• Ramprasad S, Radha V, Mathias RA, Majumder PP, Rao MR, Rema M (March 2007). "Rage gene promoter polymorphisms and diabetic retinopathy in a clinic-based population from South India". Eye. 21 (3): 395–401. doi: 10.1038/sj.eye.6702239 . PMID   16440015.
• Lindholm E, Bakhtadze E, Sjögren M, Cilio CM, Agardh E, Groop L, Agardh CD (November 2006). "The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients". Diabetologia. 49 (11): 2745–55. doi: 10.1007/s00125-006-0412-3 . PMID   16969646.
• Dumitriu IE, Bianchi ME, Bacci M, Manfredi AA, Rovere-Querini P (January 2007). "The secretion of HMGB1 is required for the migration of maturing dendritic cells". Journal of Leukocyte Biology. 81 (1): 84–91. doi:10.1189/jlb.0306171. PMID   17035340. S2CID   43269992.
• Pérez-Cabello JA, Silvera-Carrasco L, Franco JM, Capilla-González V, Armaos A, Gómez-Lima M, García-García R, Yap XW, Leal-Lasarte M, Lall D, Baloh RH, Martínez S, Miyata Y, Tartaglia GG, Sawarkar R, García-Domínguez M, Pozo D, Roodveldt C (July 2023). "MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS". Proceedings of the National Academy of Sciences of the United States of America. 120 (28) e2302143120. doi: 10.1073/pnas.2302143120 . PMC   10334760 . PMID   37399380.