RAI2

RAI2
Identifiers
Aliases	RAI2 , retinoic acid induced 2
External IDs	OMIM: 300217 MGI: 1344378 HomoloGene: 11034 GeneCards: RAI2
Gene location (Human)
Chr.	X chromosome (human)
End	17,861,337 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	160,562,492 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; urethra; ; right lung; ; canal of the cervix; ; saphenous vein; ; gastric mucosa; ; vena cava; ; myometrium; ; lower lobe of lung; ; subcutaneous adipose tissue;
	Top expressed in
	myocardium of ventricle; ; intercostal muscle; ; cumulus cells; ; supraoptic nucleus; ; pineal gland; ; aortic valve; ; islet of Langerhans; ; ganglionic eminence; ; medial ganglionic eminence; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; molecular function ;
Cellular component	cellular component ;
Biological process	embryo development ending in birth or egg hatching ;
	Sources:Amigo / QuickGO
Orthologs
	10742
	24004
	ENSG00000131831
	ENSMUSG00000043518
	Q9Y5P3
	Q9QVY8
	NM_001172732 ; NM_001172739 ; NM_001172743 ; NM_021785
	NM_001103367 ; NM_198409
NP_001166203 ; NP_001166210 ; NP_001166214 ; NP_068557 ; NP_001166210.1 ;
	NP_001166214.1 ; NP_068557.3
	NP_001096837 ; NP_940801
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 05, 2022

Retinoic acid-induced protein 2 is a protein that in humans is encoded by the RAI2 gene.^[5]^[6]^[7]

Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this intronless, retinoic acid-induced gene has not yet been determined; however, it has been suggested to play a role in development. Localization of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked mental retardation, oral-facial-digital syndrome, and Fried syndrome.^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131831 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043518 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Walpole SM, Hiriyana KT, Nicolaou A, Bingham EL, Durham J, Vaudin M, Ross MT, Yates JR, Sieving PA, Trump D (May 1999). "Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22". Genomics. 55 (3): 275–83. doi:10.1006/geno.1998.5667. PMID 10049581.
↑ Walpole SM, Ronce N, Grayson C, Dessay B, Yates JR, Trump D, Toutain A (Jul 1999). "Exclusion of RAI2 as the causative gene for Nance-Horan syndrome". Hum Genet. 104 (5): 410–1. doi:10.1007/s004390050976. PMID 10394933. S2CID 5675053.
1 2 "Entrez Gene: RAI2 retinoic acid induced 2".

Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131831 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043518 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10049581-5] Walpole SM, Hiriyana KT, Nicolaou A, Bingham EL, Durham J, Vaudin M, Ross MT, Yates JR, Sieving PA, Trump D (May 1999). "Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22". Genomics. 55 (3): 275–83. doi:10.1006/geno.1998.5667. PMID 10049581.

[pmid10394933-6] Walpole SM, Ronce N, Grayson C, Dessay B, Yates JR, Trump D, Toutain A (Jul 1999). "Exclusion of RAI2 as the causative gene for Nance-Horan syndrome". Hum Genet. 104 (5): 410–1. doi:10.1007/s004390050976. PMID 10394933. S2CID 5675053.

[entrez-7] 1 2 "Entrez Gene: RAI2 retinoic acid induced 2".

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RAI2

Related Research Articles

References

Further reading