RAI2

RAI2
Identifiers
Aliases	RAI2 , retinoic acid induced 2
External IDs	OMIM: 300217; MGI: 1344378; HomoloGene: 11034; GeneCards: RAI2; OMA:RAI2 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xp22.13 Start 17,800,049 bp [1] End 17,861,337 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X F4 Start 160,500,065 bp [2] End 160,562,492 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube urethra right lung canal of the cervix body of uterus saphenous vein gastric mucosa left ovary vena cava decidua Top expressed in myocardium of ventricle intercostal muscle cumulus cell supraoptic nucleus pineal gland aortic valve muscle of thigh islet of Langerhans Rostral migratory stream ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component cellular component Biological process embryo development ending in birth or egg hatching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10742 24004 Ensembl ENSG00000131831 ENSMUSG00000043518 UniProt Q9Y5P3 Q9QVY8 RefSeq (mRNA) NM_001172732 NM_001172739 NM_001172743 NM_021785 NM_001103367 NM_198409 RefSeq (protein) NP_001166203 NP_001166210 NP_001166214 NP_068557 NP_001166210.1 NP_001166214.1 NP_068557.3 NP_001096837 NP_940801 Location (UCSC) Chr X: 17.8 – 17.86 Mb Chr X: 160.5 – 160.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This article is about the protein. For the Italian television channel, see Rai 2.

Retinoic acid-induced protein 2 is a protein that in humans is encoded by the RAI2 gene. ^{[5] [6] [7]}

Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this intronless, retinoic acid-induced gene has not yet been determined; however, it has been suggested to play a role in development. Localization of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked mental retardation, oral-facial-digital syndrome, and Fried syndrome. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000131831 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043518 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Walpole SM, Hiriyana KT, Nicolaou A, Bingham EL, Durham J, Vaudin M, Ross MT, Yates JR, Sieving PA, Trump D (May 1999). "Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22". Genomics. 55 (3): 275–83. doi:10.1006/geno.1998.5667. PMID   10049581.
6. Walpole SM, Ronce N, Grayson C, Dessay B, Yates JR, Trump D, Toutain A (Jul 1999). "Exclusion of RAI2 as the causative gene for Nance-Horan syndrome". Hum Genet. 104 (5): 410–1. doi:10.1007/s004390050976. PMID   10394933. S2CID   5675053.
7. "Entrez Gene: RAI2 retinoic acid induced 2".

Further reading

• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.