RAP2B

RAP2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N4P, 1N4Q, 1N4R, 1N4S
Identifiers
Aliases	RAP2B , member of RAS oncogene family
External IDs	OMIM: 179541; MGI: 1921262; HomoloGene: 55701; GeneCards: RAP2B; OMA:RAP2B - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q25.2 Start 153,162,226 bp [1] End 153,170,627 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 E1 Start 61,269,059 bp [2] End 61,275,851 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium germinal epithelium buccal mucosa cell amniotic fluid tendon of biceps brachii mucosa of pharynx hair follicle human penis palpebral conjunctiva secondary oocyte Top expressed in aortic valve cumulus cell ascending aorta epithelium of lens lumbar subsegment of spinal cord Rostral migratory stream tibiofemoral joint calvaria external carotid artery dorsal striatum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein domain specific binding GDP binding GTP binding protein binding GTPase activity Cellular component recycling endosome cytosol endosome membrane cell-cell contact zone bicellular tight junction recycling endosome membrane membrane raft extracellular exosome plasma membrane specific granule membrane tertiary granule membrane Biological process regulation of protein tyrosine kinase activity microvillus assembly establishment of endothelial intestinal barrier Rap protein signal transduction platelet activation negative regulation of cell migration positive regulation of protein autophosphorylation platelet aggregation signal transduction neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5912 74012 Ensembl ENSG00000181467 ENSMUSG00000036894 UniProt P61225 P61226 RefSeq (mRNA) NM_002886 NM_028712 RefSeq (protein) NP_002877 NP_082988 Location (UCSC) Chr 3: 153.16 – 153.17 Mb Chr 3: 61.27 – 61.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rap-2b is a protein that in humans is encoded by the RAP2B gene. ^{[5] [6]} RAP2B belongs to the Ras-related protein family.

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000181467 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036894 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ohmstede CA, Farrell FX, Reep BR, Clemetson KJ, Lapetina EG (Oct 1990). "RAP2B: a RAS-related GTP-binding protein from platelets". Proc Natl Acad Sci U S A. 87 (17): 6527–31. Bibcode:1990PNAS...87.6527O. doi: 10.1073/pnas.87.17.6527 . PMC   54569 . PMID   2118648.
6. "Entrez Gene: RAP2B RAP2B, member of RAS oncogene family".

Further reading

• Farrell FX, Ohmstede CA, Reep BR, Lapetina EG (1990). "cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2". Nucleic Acids Res. 18 (14): 4281. doi:10.1093/nar/18.14.4281. PMC   331220 . PMID   2115998.
• Pizon V, Chardin P, Lerosey I, et al. (1988). "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region". Oncogene. 3 (2): 201–4. PMID   3045729.
• Torti M, Ramaschi G, Sinigaglia F, et al. (1993). "Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7553–7. Bibcode:1993PNAS...90.7553T. doi: 10.1073/pnas.90.16.7553 . PMC   47180 . PMID   8356055.
• Mollinedo F, Perez-Sala D, Gajate C, et al. (1993). "Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils". FEBS Lett. 326 (1–3): 209–14. doi: 10.1016/0014-5793(93)81792-X . PMID   8391995. S2CID   6867463.
• Farrell FX, Yamamoto K, Lapetina EG (1993). "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated". Biochem. J. 289 ( Pt 2) (Pt 2): 349–55. doi:10.1042/bj2890349. PMC   1132174 . PMID   8424780.
• Nancy V, Wolthuis RM, de Tand MF, et al. (1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. doi: 10.1074/jbc.274.13.8737 . PMID   10085114.
• Rebhun JF, Castro AF, Quilliam LA (2001). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". J. Biol. Chem. 275 (45): 34901–8. doi: 10.1074/jbc.M005327200 . PMID   10934204.
• Nancy V, Callebaut I, El Marjou A, de Gunzburg J (2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". J. Biol. Chem. 277 (17): 15076–84. doi: 10.1074/jbc.M109983200 . PMID   11786539.
• Evellin S, Nolte J, Tysack K, et al. (2002). "Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B". J. Biol. Chem. 277 (19): 16805–13. doi: 10.1074/jbc.M112024200 . PMID   11877431.
• Song C, Satoh T, Edamatsu H, et al. (2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene. 21 (53): 8105–13. doi: 10.1038/sj.onc.1206003 . PMID   12444546.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Greco F, Sinigaglia F, Balduini C, Torti M (2005). "Activation of the small GTPase Rap2B in agonist-stimulated human platelets". J. Thromb. Haemost. 2 (12): 2223–30. doi: 10.1111/j.1538-7836.2004.01018.x . PMID   15613030. S2CID   25336596.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Liu Y, Sun W, Zhang K, et al. (2007). "Identification of genes differentially expressed in human primary lung squamous cell carcinoma". Lung Cancer. 56 (3): 307–17. doi:10.1016/j.lungcan.2007.01.016. PMID   17316888.