RAPH1

RAPH1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4GMV, 4GN1
Identifiers
Aliases	RAPH1 , ALS2CR18, ALS2CR9, LPD, PREL-2, PREL2, RMO1, RalGDS/AF-6, Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
External IDs	OMIM: 609035; MGI: 1924550; HomoloGene: 71030; GeneCards: RAPH1; OMA:RAPH1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	203,535,335 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	60,606,263 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; tibia; ; pancreatic ductal cell; ; endothelial cell; ; synovial joint; ; synovial membrane; ; visceral pleura; ; skin of arm; ; cartilage tissue; ; pars reticulata;
	Top expressed in
	otolith organ; ; utricle; ; body of femur; ; Rostral migratory stream; ; myocardium of ventricle; ; adrenal gland; ; superior cervical ganglion; ; substantia nigra; ; soleus muscle; ; left lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; filopodium ; cell projection ; cytoskeleton ; cell leading edge ; membrane ; lamellipodium ; cytosol ; plasma membrane ; nuclear body ;
Biological process	signal transduction ; axon extension ;
	Sources:Amigo / QuickGO
Orthologs
	65059
	77300
	ENSG00000173166
	ENSMUSG00000026014
	Q70E73
	n/a
	NM_025252 ; NM_203365 ; NM_213589 ; NM_001329728
	NM_001045513
	NP_001316657 ; NP_976241 ; NP_998754
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 16, 2024

Ras-associated and pleckstrin homology domains-containing protein 1 is a protein that in humans is encoded by the RAPH1 gene.^[5]

Related Research Articles

Vasodilator-stimulated phosphoprotein is a protein that in humans is encoded by the VASP gene.

Drebrin is a protein that in humans is encoded by the DBN1 gene.

Ena/VASP-like protein is a member of the Ena/VASP family of proteins that in humans is encoded by the EVL gene.

Actin, gamma-enteric smooth muscle is a protein that in humans is encoded by the ACTG2 gene.

TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.

Scinderin is a protein that in humans is encoded by the SCIN gene. Scinderin is an actin severing protein belonging to the gelsolin superfamily. It was discovered in Dr. Trifaro's laboratory at the University of Ottawa, Canada. Secretory tissues are rich in scinderin. In these tissues scinderin, a calcium dependent protein, regulates cortical actin networks. Normally secretory vesicles are excluded from release sites on the plasma membrane by the presence of a cortical actin filament network. During cell stimulation, calcium channels open allowing calcium ions to enter the secretory cell. Increase in intracellular calcium activates scinderin with the consequent actin filament severing and local dissociation of actin filament networks. This allows the movement of secretory vesicles to release sites on the plasma membrane.

Erythroid membrane-associated protein is a protein that in humans is responsible for the Scianna blood group system, and is encoded by the ERMAP gene.

Pleckstrin homology domain-containing family A member 5 is a protein that in humans is encoded by the PLEKHA5 gene.

Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.

WAS/WASL-interacting protein family member 2 is a protein that in humans is encoded by the WIPF2 gene.

Dishevelled-associated activator of morphogenesis 1 is a protein that in humans is encoded by the DAAM1 gene. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.

Pleckstrin homology domain-containing family B member 2 is a protein that in humans is encoded by the PLEKHB2 gene.

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.

FYVE, RhoGEF and PH domain-containing protein 4 is a protein encoded in humans by the FGD4 gene.

Connector enhancer of kinase suppressor of ras 2, also known as CNK homolog protein 2 (CNK2) or MAGUIN, is an enzyme that in humans is encoded by the CNKSR2 gene.

Pleckstrin homology domain-containing family A member 6 is a protein that in humans is encoded by the PLEKHA6 gene.

Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.

Ras-related protein Rab-8B is a protein that in humans is encoded by the RAB8B gene.

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting protein 1 or Rap1-GTP-interacting adapter molecule (RIAM) is a protein that in humans is encoded by the APBB1IP gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000173166 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026014 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1".

Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi: 10.1093/dnares/7.6.347 . PMID 11214970.
Hadano S, Hand CK, Osuga H, et al. (2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat. Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298. S2CID 52828189.
Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". J. Biol. Chem. 278 (49): 49031–43. doi: 10.1074/jbc.M308104200 . PMID 14506234.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Krause M, Leslie JD, Stewart M, et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics". Dev. Cell. 7 (4): 571–83. doi: 10.1016/j.devcel.2004.07.024 . PMID 15469845.
Dahl E, Sadr-Nabavi A, Klopocki E, et al. (2005). "Systematic identification and molecular characterization of genes differentially expressed in breast and ovarian cancer". J. Pathol. 205 (1): 21–8. doi:10.1002/path.1687. PMID 15586368. S2CID 8336323.
Eppert K, Wunder JS, Aneliunas V, et al. (2005). "Altered expression and deletion of RMO1 in osteosarcoma". Int. J. Cancer. 114 (5): 738–46. doi:10.1002/ijc.20786. PMID 15609301. S2CID 23990601.
Jenzora A, Behrendt B, Small JV, et al. (2005). "PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins". FEBS Lett. 579 (2): 455–63. doi:10.1016/j.febslet.2004.10.110. PMID 15642358. S2CID 25677449.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID 15815621.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000173166 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026014 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1".

[1]

[2]

[3]

[4]

[5]

RAPH1

Related Research Articles

References

Further reading