RASA4

RASA4
Identifiers
Aliases	RASA4 , CAPRI, GAPL, RAS p21 protein activator 4
External IDs	OMIM: 607943 MGI: 1858600 HomoloGene: 5080 GeneCards: RASA4
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q22.1 Start 102,579,646 bp [1] End 102,616,756 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G2 Start 136,083,916 bp [2] End 136,111,860 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle skeletal muscle tissue sural nerve right coronary artery myometrium subcutaneous adipose tissue canal of the cervix gastric mucosa ganglionic eminence vagina Top expressed in secondary oocyte plantaris muscle extensor digitorum longus muscle ankle joint lip skeletal muscle tissue cerebellar cortex spleen tibialis anterior muscle mirror More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity metal ion binding phospholipid binding Cellular component cytoplasm cytosol membrane intrinsic component of the cytoplasmic side of the plasma membrane plasma membrane Biological process intracellular signal transduction regulation of GTPase activity MAPK cascade negative regulation of GTPase activity signal transduction positive regulation of GTPase activity negative regulation of Ras protein signal transduction cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10156 54153 Ensembl ENSG00000105808 ENSMUSG00000004952 UniProt O43374 Q6PFQ7 RefSeq (mRNA) NM_001079877 NM_006989 NM_001039103 NM_133914 RefSeq (protein) NP_001073346 NP_008920 NP_001034192 NP_598675 Location (UCSC) Chr 7: 102.58 – 102.62 Mb Chr 5: 136.08 – 136.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene. ^{[5] [6]}

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates as GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000105808 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004952 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lockyer PJ, Kupzig S, Cullen PJ (Jul 2001). "CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway". Curr Biol. 11 (12): 981–6. doi: 10.1016/S0960-9822(01)00261-5 . PMID   11448776. S2CID   18141962.
6. "Entrez Gene: RASA4 RAS p21 protein activator 4".

Further reading

• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
• Minagawa T, Fukuda M, Mikoshiba K (2001). "Distinct phosphoinositide binding specificity of the GAP1 family proteins: characterization of the pleckstrin homology domains of MRASAL and KIAA0538". Biochem. Biophys. Res. Commun. 288 (1): 87–90. doi:10.1006/bbrc.2001.5740. PMID   11594756.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Liu Q, Walker SA, Gao D, et al. (2005). "CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+". J. Cell Biol. 170 (2): 183–90. doi:10.1083/jcb.200504167. PMC   1351313 . PMID   16009725.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.

External links

• RASA4 human gene location in the UCSC Genome Browser .
• RASA4 human gene details in the UCSC Genome Browser .