RASAL2

RASAL2
Identifiers
Aliases	RASAL2 , NGAP, RAS protein activator like 2
External IDs	OMIM: 606136 MGI: 2443881 HomoloGene: 35217 GeneCards: RASAL2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	178,484,147 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	157,240,165 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; right ventricle; ; oral cavity; ; middle temporal gyrus; ; saphenous vein; ; sural nerve; ; Brodmann area 23; ; visceral pleura; ; popliteal artery; ; bronchial epithelial cell;
	Top expressed in
	sciatic nerve; ; utricle; ; primary motor cortex; ; cingulate gyrus; ; trigeminal ganglion; ; piriform cortex; ; temporal lobe; ; prefrontal cortex; ; mammillary body; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; GTPase activator activity ;
Cellular component	cytoplasm ; cytosol ; intrinsic component of the cytoplasmic side of the plasma membrane ;
Biological process	negative regulation of Ras protein signal transduction ; regulation of GTPase activity ; signal transduction ; MAPK cascade ; positive regulation of GTPase activity ;
	Sources:Amigo / QuickGO
Orthologs
	9462
	226525
	ENSG00000075391
	ENSMUSG00000070565
	Q9UJF2
	n/a
	NM_004841 ; NM_170692
	NM_177644 ; NM_001401202
	NP_004832 ; NP_733793
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 11, 2024

Ras GTPase-activating protein nGAP is an enzyme that in humans is encoded by the RASAL2 gene.^[5]^[6]

This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.^[6]

Related Research Articles

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Ras-related protein Rab-13 is a protein that in humans is encoded by the RAB13 gene.

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Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene.

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Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene.

GTP-binding protein GEM is a protein that in humans is encoded by the GEM gene.

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.

Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.

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GTPase activating protein and VPS9 domains 1, also known as GAPVD1, Gapex-5 and RME-6 is a protein which in humans is encoded by the GAPVD1 gene.

Ras-related protein Rap-1b, also known as GTP-binding protein smg p21B, is a protein that in humans is encoded by the RAP1B gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000075391 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070565 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Noto S, Maeda T, Hattori S, Inazawa J, Imamura M, Asaka M, Hatakeyama M (Jan 1999). "A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25". FEBS Lett. 441 (1): 127–31. doi: 10.1016/S0014-5793(98)01530-0 . PMID 9877179.
1 2 "Entrez Gene: RASAL2 RAS protein activator like 2".

Maekawa M, Nakamura S, Hattori S (1993). "Purification of a novel ras GTPase-activating protein from rat brain". J. Biol. Chem. 268 (30): 22948–52. doi: 10.1016/S0021-9258(18)41618-3 . PMID 8226805.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi: 10.1093/dnares/4.5.345 . PMID 9455484.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID 15324660. S2CID 2371325.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000075391 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070565 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9877179-5] Noto S, Maeda T, Hattori S, Inazawa J, Imamura M, Asaka M, Hatakeyama M (Jan 1999). "A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25". FEBS Lett. 441 (1): 127–31. doi: 10.1016/S0014-5793(98)01530-0 . PMID 9877179.

[entrez-6] 1 2 "Entrez Gene: RASAL2 RAS protein activator like 2".

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RASAL2

Related Research Articles

References

Further reading