RASGEF1A

RASGEF1A
Identifiers
Aliases	RASGEF1A , CG4853, RasGEF domain family member 1A
External IDs	OMIM: 614531 MGI: 1917977 HomoloGene: 17067 GeneCards: RASGEF1A
Gene location (Human)
Chr.	Chromosome 10 (human)
End	43,267,065 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	118,068,507 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; entorhinal cortex; ; Brodmann area 46; ; postcentral gyrus; ; superior frontal gyrus; ; external globus pallidus; ; cerebellar vermis; ; occipital lobe;
	Top expressed in
	piriform cortex; ; olfactory tubercle; ; superior frontal gyrus; ; visual cortex; ; nucleus accumbens; ; primary motor cortex; ; subiculum; ; Region I of hippocampus proper; ; prefrontal cortex; ; ventromedial nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity ;
Cellular component	cytosol ;
Biological process	positive regulation of Ras protein signal transduction ; cell migration ; MAPK cascade ; small GTPase mediated signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	221002
	70727
	ENSG00000198915
	ENSMUSG00000030134
	Q8N9B8
	n/a
	NM_001282862 ; NM_145313
	NM_027526 ; NM_001316749 ; NM_001362103 ; NM_001362104 ; NM_001362105
	NP_001269791 ; NP_660356
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

RasGEF domain family, member 1A is a protein that in humans is encoded by the RASGEF1A gene.^[5]

Related Research Articles

Ras-related protein Rap-1A is a protein that in humans is encoded by the RAP1A gene.

Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene. RAP2A is a member of the Ras-related protein family.

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. This protein is also called RhoGEF12 or Leukemia-associated Rho guanine nucleotide exchange factor (LARG).

Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.

Ras-related protein Rap-2b is a protein that in humans is encoded by the RAP2B gene. RAP2B belongs to the Ras-related protein family.

Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the MRAS gene on chromosome 3. It is ubiquitously expressed in many tissues and cell types. This protein functions as a signal transducer for a wide variety of signaling pathways, including those promoting neural and bone formation as well as tumor growth. The MRAS gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

Mitochondrial GTPase 1 is an enzyme that in humans is encoded by the MTG1 gene.

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.

GRIP1-associated protein 1 is a protein that in humans is encoded by the GRIPAP1 gene.

GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene.

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.

RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.

RAS guanyl-releasing protein 2 is a protein that in humans is encoded by the RASGRP2 gene.

Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.

RCC1 and BTB domain-containing protein 2 is a protein that in humans is encoded by the RCBTB2 gene.

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.

Rap guanine nucleotide exchange factor 6 is a protein that in humans is encoded by the RAPGEF6 gene.

Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene.

RasGEF domain family member 1C is a protein that in humans is encoded by the RASGEF1C gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198915 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030134 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: RasGEF domain family, member 1A".

Ura K, Obama K, Satoh S, Sakai Y, Nakamura Y, Furukawa Y (Nov 2006). "Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma". Clinical Cancer Research. 12 (22): 6611–6. doi: 10.1158/1078-0432.CCR-06-0783 . PMID 17121879.
Emison ES, McCallion AS, Kashuk CS, Bush RT, Grice E, Lin S, Portnoy ME, Cutler DJ, Green ED, Chakravarti A (Apr 2005). "A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk". Nature. 434 (7035): 857–63. doi:10.1038/nature03467. PMID 15829955. S2CID 4312809.
Garcia-Barcelo MM, Tang CS, Ngan ES, Lui VC, Chen Y, So MT, Leon TY, Miao XP, Shum CK, Liu FQ, Yeung MY, Yuan ZW, Guo WH, Liu L, Sun XB, Huang LM, Tou JF, Song YQ, Chan D, Cheung KM, Wong KK, Cherny SS, Sham PC, Tam PK (Feb 2009). "Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2694–9. doi: 10.1073/pnas.0809630105 . PMC 2650328 . PMID 19196962.
Yaman E, Gasper R, Koerner C, Wittinghofer A, Tazebay UH (Aug 2009). "RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange". The FEBS Journal. 276 (16): 4607–16. doi:10.1111/j.1742-4658.2009.07166.x. hdl: 11693/22668 . PMID 19645719. S2CID 13584642.
Burzynski GM, Nolte IM, Bronda A, Bos KK, Osinga J, Plaza Menacho I, Twigt B, Maas S, Brooks AS, Verheij JB, Buys CH, Hofstra RM (May 2005). "Identifying candidate Hirschsprung disease-associated RET variants". American Journal of Human Genetics. 76 (5): 850–8. doi:10.1086/429589. PMC 1199373 . PMID 15759212.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198915 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030134 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RasGEF domain family, member 1A".

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RASGEF1A

Related Research Articles

References

Further reading