RASGRF2

RASGRF2
Identifiers
Aliases	RASGRF2 , GRF2, RAS-GRF2, Ras protein specific guanine nucleotide releasing factor 2
External IDs	OMIM: 606614; MGI: 109137; HomoloGene: 2169; GeneCards: RASGRF2; OMA:RASGRF2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q14.1 Start 80,960,363 bp [1] End 81,230,162 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13 C3|13 47.43 cM Start 92,028,519 bp [2] End 92,268,164 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 endothelial cell sural nerve Brodmann area 46 prefrontal cortex corpus callosum superior frontal gyrus C1 segment occipital lobe Top expressed in ventromedial nucleus olfactory tubercle neural layer of retina arcuate nucleus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus substantia nigra superior frontal gyrus dentate gyrus of hippocampal formation granule cell ventral tegmental area More reference expression data BioGPS n/a
Gene ontology Molecular function calmodulin binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol endoplasmic reticulum membrane membrane plasma membrane endoplasmic reticulum Biological process regulation of Ras protein signal transduction MAPK cascade positive regulation of apoptotic process regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction small GTPase mediated signal transduction response to endoplasmic reticulum stress G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5924 19418 Ensembl ENSG00000113319 ENSMUSG00000021708 UniProt O14827 P70392 RefSeq (mRNA) NM_006909 NM_009027 RefSeq (protein) NP_008840 NP_033053 Location (UCSC) Chr 5: 80.96 – 81.23 Mb Chr 13: 92.03 – 92.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene. ^[5]

RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM] ^[5]

Variations in this gene has been shown to be linked to the propensity to binge drink by teenagers. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000113319 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021708 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2".
6. "Binge Drinking Gene: RASGRF-2 Helps Explain Teenage Alcohol Abuse, Scientists Say". Huffington Post. 3 December 2012.

Further reading

• Fam NP, Zhang LJ, Rommens JM, et al. (1997). "Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene". Genomics. 39 (1): 118–20. doi:10.1006/geno.1996.4484. PMID   9027497.
• Fam NP, Fan WT, Wang Z, et al. (1997). "Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras". Mol. Cell. Biol. 17 (3): 1396–406. doi:10.1128/mcb.17.3.1396. PMC   231864 . PMID   9032266.
• Fan WT, Koch CA, de Hoog CL, et al. (1998). "The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways". Curr. Biol. 8 (16): 935–8. Bibcode:1998CBio....8..935F. doi: 10.1016/S0960-9822(07)00376-4 . PMID   9707409. S2CID   8904502.
• Anborgh PH, Qian X, Papageorge AG, et al. (1999). "Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf". Mol. Cell. Biol. 19 (7): 4611–22. doi:10.1128/mcb.19.7.4611. PMC   84259 . PMID   10373510.
• Lutchman M, Kim AC, Cheng L, et al. (2002). "Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways". Eur. J. Biochem. 269 (2): 638–49. doi: 10.1046/j.0014-2956.2001.02694.x . PMID   11856323.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Arozarena I, Matallanas D, Berciano MT, et al. (2004). "Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors" (PDF). Mol. Cell. Biol. 24 (4): 1516–30. doi:10.1128/MCB.24.4.1516-1530.2004. PMC   344182 . PMID   14749369.
• Chen H, Suzuki M, Nakamura Y, et al. (2006). "Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer". Oncol. Rep. 15 (5): 1281–5. doi: 10.3892/or.15.5.1281 . PMID   16596198.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Ruiz S, Santos E, Bustelo XR (2007). "RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses". Mol. Cell. Biol. 27 (23): 8127–42. doi:10.1128/MCB.00912-07. PMC   2169177 . PMID   17923690.