Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene. [4]
RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM] [4]
Variations in this gene has been shown to be linked to the propensity to binge drink by teenagers. [5]
Small GTPases, also known as small G-proteins, are a family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate (GTP). They are a type of G-protein found in the cytosol that are homologous to the alpha subunit of heterotrimeric G-proteins, but unlike the alpha subunit of G proteins, a small GTPase can function independently as a hydrolase enzyme to bind to and hydrolyze a guanosine triphosphate (GTP) to form guanosine diphosphate (GDP). The best-known members are the Ras GTPases and hence they are sometimes called Ras subfamily GTPases.
Ran also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.
Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.
Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.
Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene.
Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.
Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.
Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.
Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the EIF2B4 gene.
Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.
C-jun-amino-terminal kinase-interacting protein 2 is a protein or the name of the gene that encodes it. The gene is also known as Islet-Brain-2 (IB2).
Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.
Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.
Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene.
Mitochondrial GTPase 1 is an enzyme that in humans is encoded by the MTG1 gene.
Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.
ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.
Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.
RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.
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