RASGRF2

Last updated
RASGRF2
Identifiers
Aliases RASGRF2 , GRF2, RAS-GRF2, Ras protein specific guanine nucleotide releasing factor 2
External IDs OMIM: 606614 MGI: 109137 HomoloGene: 2169 GeneCards: RASGRF2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006909

NM_009027

RefSeq (protein)

NP_008840

NP_033053

Location (UCSC) Chr 5: 80.96 – 81.23 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene. [4]

RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM] [4]

Variations in this gene has been shown to be linked to the propensity to binge drink by teenagers. [5]

Related Research Articles

Small GTPases, also known as small G-proteins, are a family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate (GTP). They are a type of G-protein found in the cytosol that are homologous to the alpha subunit of heterotrimeric G-proteins, but unlike the alpha subunit of G proteins, a small GTPase can function independently as a hydrolase enzyme to bind to and hydrolyze a guanosine triphosphate (GTP) to form guanosine diphosphate (GDP). The best-known members are the Ras GTPases and hence they are sometimes called Ras subfamily GTPases.

Ran (protein) GTPase functioning in nuclear transport

Ran also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.

SOS1

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.

Adapter molecule crk

Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.

MAP3K11

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.

RRAS

Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene.

G3BP1

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.

VAV2

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.

EIF2S2

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

EIF2B4

Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the EIF2B4 gene.

RANBP1

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.

MAPK8IP2

C-jun-amino-terminal kinase-interacting protein 2 is a protein or the name of the gene that encodes it. The gene is also known as Islet-Brain-2 (IB2).

RIN1

Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.

RPS6KA4

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.

SIPA1

Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene.

MTG1

Mitochondrial GTPase 1 is an enzyme that in humans is encoded by the MTG1 gene.

VAV3

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.

ARFRP1

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.

RAPGEF2

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.

RASGRP1

RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000113319 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. 1 2 "Entrez Gene: RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2".
  5. "Binge Drinking Gene: RASGRF-2 Helps Explain Teenage Alcohol Abuse, Scientists Say". Huffington Post. 3 December 2012.

Further reading