RASSF2

RASSF2
Identifiers
Aliases	RASSF2 , CENP-34, RASFADIN, Ras association domain family member 2
External IDs	OMIM: 609492; MGI: 2442060; HomoloGene: 22840; GeneCards: RASSF2; OMA:RASSF2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p13 Start 4,780,023 bp [1] End 4,823,608 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 F2 Start 131,831,335 bp [2] End 131,872,178 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve subthalamic nucleus C1 segment external globus pallidus medulla oblongata corpus callosum pars reticulata superior vestibular nucleus internal globus pallidus middle frontal gyrus Top expressed in meninges granulocyte thymus stroma of bone marrow mesenteric lymph nodes lumbar subsegment of spinal cord spleen blood optic nerve uterus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase activity Cellular component cytoplasm nucleus chromosome, centromeric region kinetochore chromosome nucleoplasm Golgi apparatus cytosol plasma membrane protein-containing complex Biological process positive regulation of JNK cascade positive regulation of protein autophosphorylation skeletal system development regulation of osteoclast differentiation negative regulation of peptidyl-serine phosphorylation regulation of osteoblast differentiation regulation of NIK/NF-kappaB signaling homeostasis of number of cells bone remodeling ossification negative regulation of NIK/NF-kappaB signaling epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade positive regulation of apoptotic process signal transduction positive regulation of protein kinase activity protein stabilization cell cycle protein phosphorylation regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9770 215653 Ensembl ENSG00000101265 ENSMUSG00000027339 UniProt P50749 Q8BMS9 RefSeq (mRNA) NM_014737 NM_170774 NM_170773 NM_175445 NM_001362866 RefSeq (protein) NP_055552 NP_739580 NP_780654 NP_001349795 Location (UCSC) Chr 20: 4.78 – 4.82 Mb Chr 2: 131.83 – 131.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene. ^{[5] [6] [7]}

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. ^[7]

Interactions

RASSF2 has been shown to interact with KRAS. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000101265 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027339 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi: 10.1093/dnares/3.1.17 . PMID   8724849.
6. Hesson LB, Wilson R, Morton D, Adams C, Walker M, Maher ER, Latif F (Jun 2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations". Oncogene. 24 (24): 3987–94. doi: 10.1038/sj.onc.1208566 . PMID   15806169.
7. "Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2".
8. Vos, Michele D; Ellis Chad A; Elam Candice; Ulku Aylin S; Taylor Barbara J; Clark Geoffrey J (Jul 2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. 278 (30). United States: 28045–51. doi: 10.1074/jbc.M300554200 . ISSN   0021-9258. PMID   12732644.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Comincini S, Castiglioni BM, Foti GM, et al. (2001). "Isolation and molecular characterization of rasfadin, a novel gene in the vicinity of the bovine prion gene". Mamm. Genome. 12 (2): 150–6. doi:10.1007/s003350010239. PMID   11210185. S2CID   11824136.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Vos MD, Ellis CA, Elam C, et al. (2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. 278 (30): 28045–51. doi: 10.1074/jbc.M300554200 . PMID   12732644.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Fujita H, Fukuhara S, Sakurai A, et al. (2005). "Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes". J. Biol. Chem. 280 (6): 5022–31. doi: 10.1074/jbc.M409701200 . PMID   15569673.
• Akino K, Toyota M, Suzuki H, et al. (2005). "The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer". Gastroenterology. 129 (1): 156–69. doi: 10.1053/j.gastro.2005.03.051 . PMID   16012945.
• Endoh M, Tamura G, Honda T, et al. (2006). "RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer". Br. J. Cancer. 93 (12): 1395–9. doi:10.1038/sj.bjc.6602854. PMC   2361541 . PMID   16265349.
• Zhang Z, Sun D, Van do N, et al. (2007). "Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma". Int. J. Cancer. 120 (1): 32–8. doi:10.1002/ijc.22185. hdl: 10616/38128 . PMID   17013896. S2CID   36204366.
• Park HW, Kang HC, Kim IJ, et al. (2007). "Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers". Int. J. Cancer. 120 (1): 7–12. doi:10.1002/ijc.22276. PMID   17013898. S2CID   31478640.
• Kumari G, Singhal PK, Rao MR, Mahalingam S (2007). "Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals". J. Mol. Biol. 367 (5): 1294–311. doi:10.1016/j.jmb.2007.01.026. PMID   17320110.
• Kaira K, Sunaga N, Tomizawa Y, et al. (2007). "Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers". Int. J. Oncol. 31 (1): 169–73. doi: 10.3892/ijo.31.1.169 . PMID   17549418.