RBM14

RBM14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DNP
Identifiers
Aliases	RBM14 , COAA, PSP2, SIP, SYTIP1, TMEM137, RNA binding motif protein 14
External IDs	OMIM: 612409 MGI: 1929092 HomoloGene: 4614 GeneCards: RBM14
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,629,934 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,861,662 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; ganglionic eminence; ; canal of the cervix; ; sural nerve; ; right lobe of thyroid gland; ; anterior pituitary; ; body of pancreas; ; left uterine tube; ; right lobe of liver; ; vagina;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; condyle; ; primitive streak; ; cumulus cell; ; Paneth cell; ; fossa; ; ureter; ; renal corpuscle; ; somite;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; protein-macromolecule adaptor activity ; transcription coregulator activity ; nuclear receptor coactivator activity ; nucleic acid binding ; RNA binding ;
Cellular component	nucleolus ; mediator complex ; transcription regulator complex ; cytoplasm ; nucleus ; nuclear speck ; nucleoplasm ; ribonucleoprotein complex ;
Biological process	glucocorticoid receptor signaling pathway ; response to hormone ; SMAD protein signal transduction ; DNA recombination ; DNA repair ; regulation of transcription, DNA-templated ; DNA replication ; intracellular estrogen receptor signaling pathway ; transcription, DNA-templated ; negative regulation of centriole replication ; histone deacetylation ; positive regulation of transcription by RNA polymerase II ; centriole assembly ; activation of innate immune response ; immune system process ; innate immune response ;
	Sources:Amigo / QuickGO
Orthologs
	10432
	56275
	ENSG00000239306
	ENSMUSG00000006456
	Q96PK6
	Q8C2Q3
	NM_032886 ; NM_001198836 ; NM_001198837 ; NM_006328
	NM_019869
	NP_001185765 ; NP_001185766 ; NP_006319
	NP_063922
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 12, 2024

RNA-binding protein 14 is a protein that in humans is encoded by the RBM14 gene.^[5]^[6]

Interactions

RBM14 has been shown to interact with TARBP2.^[7]

Related Research Articles

<span class="mw-page-title-main">Androgen receptor</span> Mammalian protein found in humans

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The nuclear receptor coactivator 1 (NCOA1), also called steroid receptor coactivator-1 (SRC-1), is a transcriptional coregulatory protein that contains several nuclear receptor–interacting domains and possesses intrinsic histone acetyltransferase activity. It is encoded by the gene NCOA1.

Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.

Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene.

Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.

Non-POU domain-containing octamer-binding protein (NonO) is a protein that in humans is encoded by the NONO gene.

GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene.

PITSLRE serine/threonine-protein kinase CDC2L2 is an enzyme that in humans is encoded by the CDC2L2 gene.

Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.

Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein that in humans is encoded by the SRA1 gene. The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1. This functional RNA also encodes a protein.

Nucleolysin TIAR is a protein that in humans is encoded by the TIAL1 gene.

Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in humans is encoded by the SRSF7 gene.

Protein SSXT is a protein that in humans is encoded by the SS18 gene.

Heterogeneous nuclear ribonucleoprotein A/B, also known as HNRNPAB, is a protein which in humans is encoded by the HNRNPAB gene. Although this gene is named HNRNPAB in reference to its first cloning as an RNA binding protein with similarity to HNRNP A and HNRNP B, it is not a member of the HNRNP A/B subfamily of HNRNPs, but groups together closely with HNRNPD/AUF1 and HNRNPDL.

RISC-loading complex subunit TARBP2 is a protein that in humans is encoded by the TARBP2 gene.

Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.

Syntaxin-binding protein 3 is a protein that in humans is encoded by the STXBP3 gene.

Cbp/p300-interacting transactivator 1 is a protein that in humans is encoded by the CITED1 gene.

RNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene.

Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000239306 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006456 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G (Sep 1997). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies". Human Molecular Genetics. 6 (9): 1559–64. doi: 10.1093/hmg/6.9.1559 . PMID 9285794.
↑ "Entrez Gene: RBM14 RNA binding motif protein 14".
↑ Iwasaki T, Chin WW, Ko L (Sep 2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". The Journal of Biological Chemistry. 276 (36): 33375–83. doi: 10.1074/jbc.M101517200 . PMID 11443112.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Iwasaki T, Chin WW, Ko L (Sep 2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". The Journal of Biological Chemistry. 276 (36): 33375–83. doi: 10.1074/jbc.M101517200 . PMID 11443112.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (Jan 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID 11790298. S2CID 14132033.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Perani M, Antonson P, Hamoudi R, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Dec 2005). "The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins". The Journal of Biological Chemistry. 280 (52): 42863–76. doi: 10.1074/jbc.M502963200 . PMID 16227627.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.
Sui Y, Yang Z, Xiong S, Zhang L, Blanchard KL, Peiper SC, Dynan WS, Tuan D, Ko L (Feb 2007). "Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers". Oncogene. 26 (6): 822–35. doi: 10.1038/sj.onc.1209847 . PMC 9245580 . PMID 16878147.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Yang Z, Sui Y, Xiong S, Liour SS, Phillips AC, Ko L (2007). "Switched alternative splicing of oncogene CoAA during embryonal carcinoma stem cell differentiation". Nucleic Acids Research. 35 (6): 1919–32. doi:10.1093/nar/gkl1092. PMC 1874587 . PMID 17337438.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000239306 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006456 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9285794-5] Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G (Sep 1997). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies". Human Molecular Genetics. 6 (9): 1559–64. doi: 10.1093/hmg/6.9.1559 . PMID 9285794.

[entrez-6] "Entrez Gene: RBM14 RNA binding motif protein 14".

[pmid11443112-7] Iwasaki T, Chin WW, Ko L (Sep 2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". The Journal of Biological Chemistry. 276 (36): 33375–83. doi: 10.1074/jbc.M101517200 . PMID 11443112.

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RBM14

Contents

Interactions

Related Research Articles

References

Further reading