RBM15

RBM15
Identifiers
Aliases	RBM15 , OTT, OTT1, SPEN, RNA binding motif protein 15, Putative RNA-binding protein 15
External IDs	OMIM: 606077 MGI: 2443205 HomoloGene: 23383 GeneCards: RBM15
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.3 Start 110,338,506 bp [1] End 110,346,681 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.3 Start 107,232,737 bp [2] End 107,240,989 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sperm endothelial cell Brodmann area 23 middle temporal gyrus parietal pleura visceral pleura hair follicle amniotic fluid optic nerve Top expressed in ciliary body lacrimal gland submandibular gland abdominal wall primitive streak retinal pigment epithelium fossa condyle renal corpuscle cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding RNA binding mRNA binding Cellular component nuclear speck nuclear membrane membrane nucleus nucleoplasm nuclear envelope RNA N6-methyladenosine methyltransferase complex Biological process branching involved in blood vessel morphogenesis ventricular septum morphogenesis mRNA splicing, via spliceosome placenta blood vessel development viral process negative regulation of myeloid cell differentiation spleen development negative regulation of transcription, DNA-templated positive regulation of transcription of Notch receptor target regulation of alternative mRNA splicing, via spliceosome RNA methylation dosage compensation by inactivation of X chromosome thrombopoietin-mediated signaling pathway regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64783 229700 Ensembl ENSG00000162775 ENSMUSG00000048109 UniProt Q96T37 Q0VBL3 RefSeq (mRNA) NM_001201545 NM_022768 NM_014092 NM_001045807 RefSeq (protein) NP_001188474 NP_073605 NP_001039272 Location (UCSC) Chr 1: 110.34 – 110.35 Mb Chr 3: 107.23 – 107.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Putative RNA-binding protein 15 is a protein that in humans is encoded by the RBM15 gene. ^{[5] [6] [7]} It is a RNA-binding protein that acts as a key regulator of N6-Methyladenosine (m⁶A) methylation of RNAs ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000162775 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048109 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK (Jun 2001). "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia". Nat Genet. 28 (3): 220–1. doi:10.1038/90054. PMID   11431691. S2CID   36236342.
6. Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA (May 2001). "Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia". Proc Natl Acad Sci U S A. 98 (10): 5776–9. Bibcode:2001PNAS...98.5776M. doi: 10.1073/pnas.101001498 . PMC   33289 . PMID   11344311.
7. "Entrez Gene: RBM15 RNA binding motif protein 15".
8. "UniProtKB - Q96T37 (RBM15_HUMAN)" . Retrieved 29 October 2018.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hsiao HH, Yang MY, Liu YC, et al. (2005). "RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient". Am. J. Hematol. 79 (1): 43–5. doi:10.1002/ajh.20298. PMID   15849773. S2CID   30859557.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Lindtner S, Zolotukhin AS, Uranishi H, et al. (2007). "RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway". J. Biol. Chem. 281 (48): 36915–28. doi: 10.1074/jbc.M608745200 . PMID   17001072.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.