RBM22

RBM22
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YTC
Identifiers
Aliases	RBM22 , Cwc2, ZC3H16, fSAP47, RNA binding motif protein 22
External IDs	OMIM: 612430; MGI: 1914060; HomoloGene: 69245; GeneCards: RBM22; OMA:RBM22 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q33.1 Start 150,690,792 bp [1] End 150,701,077 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 D3 Start 60,693,808 bp [2] End 60,705,882 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia parietal pleura germinal epithelium visceral pleura amniotic fluid ganglionic eminence blood ventricular zone secondary oocyte granulocyte Top expressed in zygote ventricular zone abdominal wall thymus epiblast tail of embryo ganglionic eminence neural layer of retina genital tubercle secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding calcium-dependent protein binding nucleic acid binding pre-mRNA binding U6 snRNA binding structural constituent of nuclear pore RNA binding protein binding Cellular component cytoplasm catalytic step 2 spliceosome U2-type catalytic step 1 spliceosome U2-type catalytic step 2 spliceosome Prp19 complex spliceosomal complex nucleus nucleoplasm Biological process positive regulation of intracellular protein transport mRNA processing spliceosomal snRNP assembly RNA splicing mRNA cis splicing, via spliceosome positive regulation of RNA splicing mRNA splicing, via spliceosome transport positive regulation of protein import into nucleus positive regulation of protein export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55696 66810 Ensembl ENSG00000086589 ENSMUSG00000024604 UniProt Q9NW64 Q8BHS3 RefSeq (mRNA) NM_018047 NM_025776 RefSeq (protein) NP_060517 NP_080052 Location (UCSC) Chr 5: 150.69 – 150.7 Mb Chr 18: 60.69 – 60.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pre-mRNA-splicing factor RBM22 is a protein that in humans is encoded by the RBM22 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000086589 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024604 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
6. "Entrez Gene: RBM22 RNA binding motif protein 22".

Further reading

• Loftus SK, Dixon J, Koprivnikar K, et al. (1996). "Transcriptional map of the Treacher Collins candidate gene region". Genome Res. 6 (1): 26–34. doi: 10.1101/gr.6.1.26 . PMID   8681136.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC   1370266 . PMID   11991638.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Montaville P, Dai Y, Cheung CY, et al. (2007). "Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22". Biochim. Biophys. Acta. 1763 (11): 1335–43. doi:10.1016/j.bbamcr.2006.09.003. hdl: 11858/00-001M-0000-0012-E387-0 . PMID   17045351.