RBM39

RBM39
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JRS, 2MHN, 4OO6, 4OZ0, 4OZ1, 4YUD
Identifiers
Aliases	RBM39 , CAPER, CAPERalpha, FSAP59, HCC1, RNPC2, RNA binding motif protein 39
External IDs	OMIM: 604739 MGI: 2157953 HomoloGene: 136465 GeneCards: RBM39
Gene location (Human)
Chr.	Chromosome 20 (human)
End	35,742,312 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	156,180,238 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; Achilles tendon; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; sural nerve; ; canal of the cervix; ; anterior pituitary; ; bone marrow cells; ; right lung; ; body of pancreas;
	Top expressed in
	spermatocyte; ; neural tube; ; medullary collecting duct; ; hand; ; cerebellar cortex; ; superior frontal gyrus; ; ganglionic eminence; ; thymus; ; dermis; ; cumulus cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding ; protein binding ; RNA binding ;
Cellular component	microtubule cytoskeleton ; nucleus ; nucleoplasm ; microtubule organizing center ; nuclear speck ; protein-containing complex ;
Biological process	mRNA processing ; RNA processing ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; RNA splicing ;
	Sources:Amigo / QuickGO
Orthologs
	9584
	170791
	ENSG00000131051
	ENSMUSG00000027620
	Q14498 ; Q5QP23
	Q8VH51
NM_001242599 ; NM_001242600 ; NM_004902 ; NM_184234 ; NM_184237 ;
	NM_184241 ; NM_184244 ; NM_001323422 ; NM_001323423 ; NM_001323424 Contents Function ; Interactions ; References ; Further reading ;
NM_001291114 ; NM_001291115 ; NM_133242 ; NM_001362763 ; NM_001362764 ;
	NM_001362765 ; NM_001362766 ; NM_001362767 ; NM_001362768 ; NM_001362769
NP_001229528 ; NP_001229529 ; NP_001310351 ; NP_001310352 ; NP_001310353 ;
	NP_004893 ; NP_909122
NP_001278043 ; NP_001278044 ; NP_573505 ; NP_001349692 ; NP_001349693 ;
	NP_001349694 ; NP_001349695 ; NP_001349696 ; NP_001349697 ; NP_001349698
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

RNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene.^[5]^[6]

Function

The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene.^[6]

Interactions

RBM39 has been shown to interact with Estrogen receptor alpha,^[7] Estrogen receptor beta ^[7] and C-jun.^[7]

Related Research Articles

Estrogen receptor alpha (ERα), also known as NR3A1, is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. In humans, ERα is encoded by the gene ESR1.

<span class="mw-page-title-main">Transcription factor Jun</span> Mammalian protein found in Homo sapiens

Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor discovered. The proto-oncogene c-Jun is the cellular homolog of the viral oncoprotein v-jun. The viral homolog v-jun was discovered in avian sarcoma virus 17 and was named for ju-nana, the Japanese word for 17. The human JUN encodes a protein that is highly similar to the viral protein, which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Estrogen receptor beta (ERβ) also known as NR3A2 is one of two main types of estrogen receptor—a nuclear receptor which is activated by the sex hormone estrogen. In humans ERβ is encoded by the ESR2 gene.

Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 is a nuclear receptor that in humans is encoded by the RXRA gene.

Estrogen-related receptor gamma (ERR-gamma), also known as NR3B3, is a nuclear receptor that in humans is encoded by the ESRRG gene. It behaves as a constitutive activator of transcription.

Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene.

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.

SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.

Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.

Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein that in humans is encoded by the SRA1 gene. The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1. This functional RNA also encodes a protein.

Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.

Transcriptional adapter 3-like is a protein that in humans is encoded by the TADA3 gene. Cytogenetic location: 3p25.3

Mediator of RNA polymerase II transcription subunit 23 is an enzyme that in humans is encoded by the MED23 gene.

RISC-loading complex subunit TARBP2 is a protein that in humans is encoded by the TARBP2 gene.

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.

RNA-binding protein 14 is a protein that in humans is encoded by the RBM14 gene.

RNA binding motif protein 9 (RBM9), also known as Rbfox2, is a protein which in humans is encoded by the RBM9 gene.

Probable RNA-binding protein 23 is a protein that in humans is encoded by the RBM23 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131051 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027620 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM (Dec 1993). "Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma". J Clin Invest. 92 (5): 2419–26. doi:10.1172/JCI116848. PMC 288425 . PMID 8227358.
1 2 "Entrez Gene: RBM39 RNA binding motif protein 39".
1 2 3 Jung DJ, Na SY, Na DS, Lee JW (Jan 2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi: 10.1074/jbc.M110417200 . PMID 11704680.

Jung DJ, Na SY, Na DS, Lee JW (2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi: 10.1074/jbc.M110417200 . PMID 11704680.
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Dowhan DH, Hong EP, Auboeuf D, Dennis AP, Wilson MM, Berget SM, O'Malley BW (2005). "Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta". Mol. Cell. 17 (3): 429–39. doi: 10.1016/j.molcel.2004.12.025 . PMID 15694343.
Sun NN, Fastje CD, Wong SS, Sheppard PR, Macdonald SJ, Ridenour G, Hyde JD, Witten ML (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and Industrial Health. 19 (7–10): 157–63. doi:10.1191/0748233703th185oa. PMID 15747776. S2CID 14394243.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131051 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027620 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8227358-5] Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM (Dec 1993). "Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma". J Clin Invest. 92 (5): 2419–26. doi:10.1172/JCI116848. PMC 288425 . PMID 8227358.

[entrez-6] 1 2 "Entrez Gene: RBM39 RNA binding motif protein 39".

[pmid11704680-7] 1 2 3 Jung DJ, Na SY, Na DS, Lee JW (Jan 2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi: 10.1074/jbc.M110417200 . PMID 11704680.

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RBM39

Contents

Function

Interactions

Related Research Articles

References

Further reading