RBM5

RBM5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LK0, 2LK1, 2LKZ
Identifiers
Aliases	RBM5 , G15, LUCA15, RMB5, H37, RNA binding motif protein 5, LUCA-15
External IDs	OMIM: 606884; MGI: 1933204; HomoloGene: 21177; GeneCards: RBM5; OMA:RBM5 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 50,088,919 bp [1] End 50,119,021 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F1 Start 107,617,570 bp [2] End 107,648,195 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube sural nerve Achilles tendon left ovary right ovary right lobe of thyroid gland canal of the cervix left lobe of thyroid gland right hemisphere of cerebellum anterior pituitary Top expressed in Rostral migratory stream genital tubercle medullary collecting duct tail of embryo saccule neural layer of retina vestibular sensory epithelium thymus vestibular membrane of cochlear duct lymph node More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding metal ion binding protein binding nucleic acid binding mRNA binding RNA binding Cellular component nucleoplasm spliceosomal complex nucleus Biological process regulation of apoptotic process mRNA splicing, via spliceosome RNA processing mRNA processing regulation of alternative mRNA splicing, via spliceosome spliceosomal complex assembly positive regulation of apoptotic process negative regulation of cell population proliferation apoptotic process RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10181 83486 Ensembl ENSG00000003756 ENSMUSG00000032580 UniProt P52756 Q91YE7 RefSeq (mRNA) NM_005778 NM_148930 NM_001359524 NM_001359525 NM_001359526 RefSeq (protein) NP_005769 NP_683732 NP_001346453 NP_001346454 NP_001346455 Location (UCSC) Chr 3: 50.09 – 50.12 Mb Chr 9: 107.62 – 107.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RNA-binding protein 5 is a protein that in humans is encoded by the RBM5 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000003756 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032580 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Timmer T, Terpstra P, van den Berg A, Veldhuis PM, Ter Elst A, Voutsinas G, Hulsbeek MM, Draaijers TG, Looman MW, Kok K, Naylor SL, Buys CH (Aug 1999). "A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3". Eur J Hum Genet. 7 (4): 478–486. doi: 10.1038/sj.ejhg.5200334 . PMID   10352938.
6. "Entrez Gene: RBM5 RNA binding motif protein 5".

Further reading

• Timmer T, Terpstra P, van den Berg A, et al. (1999). "An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3, a region frequently deleted in a variety of cancers". Genomics. 60 (2): 238–240. doi:10.1006/geno.1999.5878. PMID   10486216.
• Oh JJ, Grosshans DR, Wong SG, Slamon DJ (1999). "Identification of differentially expressed genes associated with HER-2/neu overexpression in human breast cancer cells". Nucleic Acids Res. 27 (20): 4008–4017. doi:10.1093/nar/27.20.4008. PMC   148668 . PMID   10497265.
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–464. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID   10508479. S2CID   21839750.
• Sutherland LC, Edwards SE, Cable HC, et al. (2000). "LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis". Oncogene. 19 (33): 3774–3781. doi: 10.1038/sj.onc.1203720 . PMID   10949932.
• Oh JJ, West AR, Fishbein MC, Slamon DJ (2002). "A candidate tumor suppressor gene, H37, from the human lung cancer tumor suppressor locus 3p21.3". Cancer Res. 62 (11): 3207–3213. PMID   12036935.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mourtada-Maarabouni M, Sutherland LC, Meredith JM, Williams GT (2003). "Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta-6 of the candidate tumour suppressor LUCA-15/RBM5". Genes Cells. 8 (2): 109–119. doi: 10.1046/j.1365-2443.2003.00619.x . PMID   12581154. S2CID   24099427.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Rintala-Maki ND, Sutherland LC (2005). "LUCA-15/RBM5, a putative tumour suppressor, enhances multiple receptor-initiated death signals". Apoptosis. 9 (4): 475–484. doi:10.1023/B:APPT.0000031455.79352.57. PMID   15192330. S2CID   9436571.
• Rintala-Maki ND, Abrasonis V, Burd M, Sutherland LC (2005). "Genetic instability of RBM5/LUCA-15/H37 in MCF-7 breast carcinoma sublines may affect susceptibility to apoptosis". Cell Biochem. Funct. 22 (5): 307–313. doi:10.1002/cbf.1106. PMID   15338470. S2CID   41472130.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Mourtada-Maarabouni M, Keen J, Clark J, et al. (2006). "Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes". Exp. Cell Res. 312 (10): 1745–1752. doi:10.1016/j.yexcr.2006.02.009. PMID   16546166.
• Oh JJ, Razfar A, Delgado I, et al. (2006). "3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis". Cancer Res. 66 (7): 3419–3427. doi:10.1158/0008-5472.CAN-05-1667. PMID   16585163.
• Masdeu C, Faure H, Coulombe J, et al. (2006). "Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15". Biochem. Biophys. Res. Commun. 349 (2): 471–479. doi:10.1016/j.bbrc.2006.07.216. PMID   16945339.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• RBM5 human gene location in the UCSC Genome Browser .
• RBM5 human gene details in the UCSC Genome Browser .