RCBTB2

RCBTB2
Identifiers
Aliases	RCBTB2 , CHC1L, RLG, RCC1 and BTB domain containing protein 2
External IDs	OMIM: 603524; MGI: 1917200; HomoloGene: 970; GeneCards: RCBTB2; OMA:RCBTB2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q14.2 Start 48,488,963 bp [1] End 48,533,256 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 D3 Start 73,360,477 bp [2] End 73,445,283 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte monocyte optic nerve parietal pleura visceral pleura Epithelium of choroid plexus retinal pigment epithelium seminal vesicula ganglionic eminence ventricular zone Top expressed in otic vesicle saccule otic placode mandibular prominence thymus maxillary prominence somite ventricular zone brown adipose tissue genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component acrosomal vesicle cytoplasmic vesicle Biological process regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1102 105670 Ensembl ENSG00000136161 ENSMUSG00000022106 UniProt O95199 Q99LJ7 RefSeq (mRNA) NM_001268 NM_001286830 NM_001286831 NM_001286832 NM_001352424 NM_001352425 NM_001352426 NM_001352427 NM_001352428 NM_001352429 NM_001352430 NM_001352431 NM_001170694 NM_134083 RefSeq (protein) NP_001259 NP_001273759 NP_001273760 NP_001273761 NP_001339353 NP_001339354 NP_001339355 NP_001339356 NP_001339357 NP_001339358 NP_001339359 NP_001339360 NP_001164165 NP_598844 Location (UCSC) Chr 13: 48.49 – 48.53 Mb Chr 14: 73.36 – 73.45 Mb PubMed search [3] [4]
Wikidata
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RCC1 and BTB domain-containing protein 2 is a protein that in humans is encoded by the RCBTB2 gene. ^{[5] [6]}

This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000136161 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022106 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Devilder MC, Cadoret E, Cherel M, Moreau I, Rondeau G, Bezieau S, Moisan JP (Jan 1999). "cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor". Genomics. 54 (1): 99–106. doi:10.1006/geno.1998.5498. PMID   9806834.
6. "Entrez Gene: RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2".

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC   2665288 . PMID   15057823.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Latil A, Morant P, Fournier G, Mangin P, Berthon P, Cussenot O (2002). "CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer". Int. J. Cancer. 99 (5): 689–96. doi: 10.1002/ijc.10393 . PMID   12115502. S2CID   36595791.
• Renault L, Nassar N, Wittinghofer A, Roth M, Vetter IR (1999). "Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation". Acta Crystallogr. D. 55 (Pt 1): 272–5. Bibcode:1999AcCrD..55..272R. doi:10.1107/S0907444998007768. PMID   10089422.